Enzymatic characterization of lipid-based drug delivery systems
(2005) In International Journal of Pharmaceutics 298(2). p.328-332- Abstract
- The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the... (More)
- The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/152846
- author
- Ljusberg, Helena LU ; Nielsen, F S ; Brogard, M ; Troedsson, Emma and Mullertz, A
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Self-microemulsifying drug delivery system, Lipolysis, Probucol, Halofantrine
- in
- International Journal of Pharmaceutics
- volume
- 298
- issue
- 2
- pages
- 328 - 332
- publisher
- Elsevier
- external identifiers
-
- pmid:15979260
- wos:000230856800008
- scopus:21344438401
- ISSN
- 1873-3476
- DOI
- 10.1016/j.ijpharm.2005.02.038
- language
- English
- LU publication?
- yes
- id
- debf05ff-1b60-4564-bf92-4fe9e6bc33f2 (old id 152846)
- date added to LUP
- 2016-04-01 11:56:47
- date last changed
- 2022-01-26 20:32:53
@article{debf05ff-1b60-4564-bf92-4fe9e6bc33f2,
abstract = {{The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.}},
author = {{Ljusberg, Helena and Nielsen, F S and Brogard, M and Troedsson, Emma and Mullertz, A}},
issn = {{1873-3476}},
keywords = {{Self-microemulsifying drug delivery system; Lipolysis; Probucol; Halofantrine}},
language = {{eng}},
number = {{2}},
pages = {{328--332}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{Enzymatic characterization of lipid-based drug delivery systems}},
url = {{http://dx.doi.org/10.1016/j.ijpharm.2005.02.038}},
doi = {{10.1016/j.ijpharm.2005.02.038}},
volume = {{298}},
year = {{2005}},
}