Advanced

Roles of microbiota manipulations in the ICU

Bengmark, Stig LU and Schneider, Stephane M. (2009) In Nutrition Clinique et Metabolisme 23(4). p.235-244
Abstract
The intestinal microbiota displays dramatic changes in the ICU patient, with a loss of the entire beneficial lactic bacterial flora. In situations of hyperinflammation followed by immune paresis that are due to the acute disease but also to chronic diseases and drugs used, it is crucial to reestablish inflammatory and immune homeostasis, and microbiota manipulations with probiotics or synbiotics is an instrument of choice. It is not recommended to give any ICU patient any probiotic or synbiotic, for fear of inefficacy or even increased mortality. However, there is strong evidence in elective surgery, polytrauma and acute pancreatitis for well-defined formulations of bacterial strains and fibers. The inflammatory response is immediate and... (More)
The intestinal microbiota displays dramatic changes in the ICU patient, with a loss of the entire beneficial lactic bacterial flora. In situations of hyperinflammation followed by immune paresis that are due to the acute disease but also to chronic diseases and drugs used, it is crucial to reestablish inflammatory and immune homeostasis, and microbiota manipulations with probiotics or synbiotics is an instrument of choice. It is not recommended to give any ICU patient any probiotic or synbiotic, for fear of inefficacy or even increased mortality. However, there is strong evidence in elective surgery, polytrauma and acute pancreatitis for well-defined formulations of bacterial strains and fibers. The inflammatory response is immediate and therefore administration of probiotics or synbiotics in these situations must also be immediate. (C) 2009 Elsevier Masson SAS. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute pancreatitis, Synbiotic, Probiotic, ICU, Microbiota
in
Nutrition Clinique et Metabolisme
volume
23
issue
4
pages
235 - 244
publisher
Masson Editeur
external identifiers
  • wos:000273101600009
  • scopus:71349083333
ISSN
0985-0562
DOI
10.1016/j.nupar.2009.10.007
language
French
LU publication?
yes
id
1023c07a-28f4-4efd-a130-e2e53445665d (old id 1531563)
date added to LUP
2010-01-28 11:25:03
date last changed
2017-01-01 05:45:39
@article{1023c07a-28f4-4efd-a130-e2e53445665d,
  abstract     = {The intestinal microbiota displays dramatic changes in the ICU patient, with a loss of the entire beneficial lactic bacterial flora. In situations of hyperinflammation followed by immune paresis that are due to the acute disease but also to chronic diseases and drugs used, it is crucial to reestablish inflammatory and immune homeostasis, and microbiota manipulations with probiotics or synbiotics is an instrument of choice. It is not recommended to give any ICU patient any probiotic or synbiotic, for fear of inefficacy or even increased mortality. However, there is strong evidence in elective surgery, polytrauma and acute pancreatitis for well-defined formulations of bacterial strains and fibers. The inflammatory response is immediate and therefore administration of probiotics or synbiotics in these situations must also be immediate. (C) 2009 Elsevier Masson SAS. All rights reserved.},
  author       = {Bengmark, Stig and Schneider, Stephane M.},
  issn         = {0985-0562},
  keyword      = {Acute pancreatitis,Synbiotic,Probiotic,ICU,Microbiota},
  language     = {fre},
  number       = {4},
  pages        = {235--244},
  publisher    = {Masson Editeur},
  series       = {Nutrition Clinique et Metabolisme},
  title        = {Roles of microbiota manipulations in the ICU},
  url          = {http://dx.doi.org/10.1016/j.nupar.2009.10.007},
  volume       = {23},
  year         = {2009},
}