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Age at Diagnosis and Age at Death in Familial Prostate Cancer

Brandt, Andreas; Bermejo, Justo Lorenzo; Sundquist, Jan LU and Hemminki, Kari LU (2009) In Oncologist 14(12). p.1209-1217
Abstract
Objectives. A family history of prostate cancer is associated with a higher risk for prostate cancer to first-degree relatives. If greater surveillance of men at familial risk is considered to be useful, population-based estimates of the differences in the age at diagnosis between familial and sporadic prostate cancer cases are needed. Methods. The men in the nationwide Swedish Family-Cancer Database were classified according to the number and type of affected first-degree relatives (father or brother) and according to the relative's age at diagnosis. The cumulative incidence of prostate cancer and cumulative prostate cancer-specific mortality were estimated using a stratified Cox model. Results. The cumulative incidence was highest for... (More)
Objectives. A family history of prostate cancer is associated with a higher risk for prostate cancer to first-degree relatives. If greater surveillance of men at familial risk is considered to be useful, population-based estimates of the differences in the age at diagnosis between familial and sporadic prostate cancer cases are needed. Methods. The men in the nationwide Swedish Family-Cancer Database were classified according to the number and type of affected first-degree relatives (father or brother) and according to the relative's age at diagnosis. The cumulative incidence of prostate cancer and cumulative prostate cancer-specific mortality were estimated using a stratified Cox model. Results. The cumulative incidence was highest for men with multiple affected first-degree relatives, and it was higher for brothers than for sons of prostate cancer patients. The age to reach the same cumulative incidence as the general population at age 55 years decreased with decreasing age at diagnosis of the relative, ranging from 48.7 years (father diagnosed before 60 years of age) to 53.7 years (father diagnosed after 82 years of age). Prostate cancer-specific mortality was also related to the number and type of affected relatives but there was no clear evidence for a dependency on the age at diagnosis of the relative. Conclusions. Men with a father or a brother affected by prostate cancer are diagnosed and die at earlier ages than men without a family history of prostate cancer. This study should encourage further analysis in order to assess the risks and benefits of screening for prostate cancer in men at higher risk. The Oncologist 2009; 14: 1209-1217 (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age of diagnosis, Prostate cancer, Familial prostate cancer, Cumulative, risk
in
Oncologist
volume
14
issue
12
pages
1209 - 1217
publisher
AlphaMed Press
external identifiers
  • wos:000273016500010
  • scopus:75449117726
ISSN
1083-7159
DOI
10.1634/theoncologist.2009-0132
language
English
LU publication?
yes
id
ad129093-f2c4-4901-9618-553a92ba8a14 (old id 1531933)
date added to LUP
2010-01-29 12:12:39
date last changed
2017-01-01 06:18:03
@article{ad129093-f2c4-4901-9618-553a92ba8a14,
  abstract     = {Objectives. A family history of prostate cancer is associated with a higher risk for prostate cancer to first-degree relatives. If greater surveillance of men at familial risk is considered to be useful, population-based estimates of the differences in the age at diagnosis between familial and sporadic prostate cancer cases are needed. Methods. The men in the nationwide Swedish Family-Cancer Database were classified according to the number and type of affected first-degree relatives (father or brother) and according to the relative's age at diagnosis. The cumulative incidence of prostate cancer and cumulative prostate cancer-specific mortality were estimated using a stratified Cox model. Results. The cumulative incidence was highest for men with multiple affected first-degree relatives, and it was higher for brothers than for sons of prostate cancer patients. The age to reach the same cumulative incidence as the general population at age 55 years decreased with decreasing age at diagnosis of the relative, ranging from 48.7 years (father diagnosed before 60 years of age) to 53.7 years (father diagnosed after 82 years of age). Prostate cancer-specific mortality was also related to the number and type of affected relatives but there was no clear evidence for a dependency on the age at diagnosis of the relative. Conclusions. Men with a father or a brother affected by prostate cancer are diagnosed and die at earlier ages than men without a family history of prostate cancer. This study should encourage further analysis in order to assess the risks and benefits of screening for prostate cancer in men at higher risk. The Oncologist 2009; 14: 1209-1217},
  author       = {Brandt, Andreas and Bermejo, Justo Lorenzo and Sundquist, Jan and Hemminki, Kari},
  issn         = {1083-7159},
  keyword      = {Age of diagnosis,Prostate cancer,Familial prostate cancer,Cumulative,risk},
  language     = {eng},
  number       = {12},
  pages        = {1209--1217},
  publisher    = {AlphaMed Press},
  series       = {Oncologist},
  title        = {Age at Diagnosis and Age at Death in Familial Prostate Cancer},
  url          = {http://dx.doi.org/10.1634/theoncologist.2009-0132},
  volume       = {14},
  year         = {2009},
}