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Defining Clinical Criteria for Clinical Remission and Disease Activity in Collagenous Colitis

Hjortswang, Henrik; Tysk, Curt; Bohr, Johan; Benoni, Cecilia LU ; Kilander, Anders; Larsson, Lasse; Vigren, Lira and Strom, Magnus (2009) In Inflammatory Bowel Diseases 15(12). p.1875-1881
Abstract
Background: Collagenous colitis is a chronic inflammatory bowel disease accompanied mainly by nonbloody diarrhea. The objectives of treatment are to alleviate the symptoms and minimize the deleterious effects on health-related quality of life (HRQOL). There is still no generally accepted clinical definition of remission or relapse. The purpose of this study was to analyze the impact of bowel symptoms on HRQOL and accordingly suggest criteria for remission and disease activity based on impact of patient symptoms on HRQOL. Methods: The design was a cross-sectional postal survey of 116 patients with collagenous colitis. The main outcome measures were 4 HRQOL questionnaires: the Short Health Scale, the Inflammatory Bowel Disease Questionnaire,... (More)
Background: Collagenous colitis is a chronic inflammatory bowel disease accompanied mainly by nonbloody diarrhea. The objectives of treatment are to alleviate the symptoms and minimize the deleterious effects on health-related quality of life (HRQOL). There is still no generally accepted clinical definition of remission or relapse. The purpose of this study was to analyze the impact of bowel symptoms on HRQOL and accordingly suggest criteria for remission and disease activity based on impact of patient symptoms on HRQOL. Methods: The design was a cross-sectional postal survey of 116 patients with collagenous colitis. The main outcome measures were 4 HRQOL questionnaires: the Short Health Scale, the Inflammatory Bowel Disease Questionnaire, the Rating Form of IBD Patient Concerns, and the Psychological General Well-Being Index, and a 1-week symptom diary recording number of stools/day and number of watery stools/day. Results: Severity of bowel symptoms had a deleterious impact on patients' HRQOL. Patients with a mean of >= 3 stools/day or a mean of >= 1 watery stool/day had a significantly impaired HRQOL compared to those with <3 stools/day and < 1 watery stool/day. Conclusions: We propose that clinical remission in collagenous colitis is defined as a mean of <3 stools/day and a mean of < 1 watery stool per clay and disease activity to be a daily mean of >= 3 stools or a mean of >= 1 watery stool. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
quality of life, health-related quality of life, health, colitis, collagenous, microscopic colitis, IBD, inflammatory bowel disease, remission, disease activity
in
Inflammatory Bowel Diseases
volume
15
issue
12
pages
1875 - 1881
publisher
John Wiley & Sons
external identifiers
  • wos:000272568600016
  • scopus:72549086962
ISSN
1536-4844
DOI
10.1002/ibd.20977
language
English
LU publication?
yes
id
5c752fb5-2960-48a9-b766-effa2986ebaf (old id 1532701)
date added to LUP
2010-01-29 10:42:07
date last changed
2017-12-10 03:52:55
@article{5c752fb5-2960-48a9-b766-effa2986ebaf,
  abstract     = {Background: Collagenous colitis is a chronic inflammatory bowel disease accompanied mainly by nonbloody diarrhea. The objectives of treatment are to alleviate the symptoms and minimize the deleterious effects on health-related quality of life (HRQOL). There is still no generally accepted clinical definition of remission or relapse. The purpose of this study was to analyze the impact of bowel symptoms on HRQOL and accordingly suggest criteria for remission and disease activity based on impact of patient symptoms on HRQOL. Methods: The design was a cross-sectional postal survey of 116 patients with collagenous colitis. The main outcome measures were 4 HRQOL questionnaires: the Short Health Scale, the Inflammatory Bowel Disease Questionnaire, the Rating Form of IBD Patient Concerns, and the Psychological General Well-Being Index, and a 1-week symptom diary recording number of stools/day and number of watery stools/day. Results: Severity of bowel symptoms had a deleterious impact on patients' HRQOL. Patients with a mean of &gt;= 3 stools/day or a mean of &gt;= 1 watery stool/day had a significantly impaired HRQOL compared to those with &lt;3 stools/day and &lt; 1 watery stool/day. Conclusions: We propose that clinical remission in collagenous colitis is defined as a mean of &lt;3 stools/day and a mean of &lt; 1 watery stool per clay and disease activity to be a daily mean of &gt;= 3 stools or a mean of &gt;= 1 watery stool.},
  author       = {Hjortswang, Henrik and Tysk, Curt and Bohr, Johan and Benoni, Cecilia and Kilander, Anders and Larsson, Lasse and Vigren, Lira and Strom, Magnus},
  issn         = {1536-4844},
  keyword      = {quality of life,health-related quality of life,health,colitis,collagenous,microscopic colitis,IBD,inflammatory bowel disease,remission,disease activity},
  language     = {eng},
  number       = {12},
  pages        = {1875--1881},
  publisher    = {John Wiley & Sons},
  series       = {Inflammatory Bowel Diseases},
  title        = {Defining Clinical Criteria for Clinical Remission and Disease Activity in Collagenous Colitis},
  url          = {http://dx.doi.org/10.1002/ibd.20977},
  volume       = {15},
  year         = {2009},
}