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Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men

Lee, David M.; Rutter, Martin K.; O'Neill, Terrence W.; Boonen, Steven; Vandershueren, Dirk; Bouillon, Roger; Bartfai, Gyorgy; Casanueva, Felipe F.; Finn, Joseph D. and Forti, Gianni, et al. (2009) In European Journal of Endocrinology1994-01-01+01:00 161(6). p.947-954
Abstract
Objectives: Low serum 25-hydroxyviatmin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men Design: This was a population-based, cross-sectional study of 3369 men aged 40-79 years enrolled in the European Male Ageing Study. Results After exclusion of subjects with missing data. 3069 men with a mean... (More)
Objectives: Low serum 25-hydroxyviatmin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men Design: This was a population-based, cross-sectional study of 3369 men aged 40-79 years enrolled in the European Male Ageing Study. Results After exclusion of subjects with missing data. 3069 men with a mean (+/- S.D.) age of 60 +/- 11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic blood pressure (BP), triglycerides, and glucose (all P < 0.01) Age-adjusted PTH levels were only associated with waist and diastolic BP (both P < 0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (odds ratios 0.48 (95% confidence intervals 0.36-0.64) highest versus lowest quintile. P-trend < 0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for homeostasis model assessment of insulin resistance (0.60 (0.47-0.78) P-trend < 0.001) There was no association between PTH and MetS. Conclusions: Our results demonstrate an inverse relationship between 25(OH)D levels and MetS, which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study (Less)
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published
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European Journal of Endocrinology1994-01-01+01:00
volume
161
issue
6
pages
947 - 954
publisher
Society of the European Journal of Endocrinology
external identifiers
  • wos:000272527400018
  • scopus:72949121915
ISSN
1479-683X
DOI
10.1530/EJE-09-0496
language
English
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yes
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9b1d3562-7579-45ba-97be-3d3b62fda9e0 (old id 1533537)
date added to LUP
2010-01-27 16:01:17
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2017-12-10 03:48:10
@article{9b1d3562-7579-45ba-97be-3d3b62fda9e0,
  abstract     = {Objectives: Low serum 25-hydroxyviatmin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men Design: This was a population-based, cross-sectional study of 3369 men aged 40-79 years enrolled in the European Male Ageing Study. Results After exclusion of subjects with missing data. 3069 men with a mean (+/- S.D.) age of 60 +/- 11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic blood pressure (BP), triglycerides, and glucose (all P &lt; 0.01) Age-adjusted PTH levels were only associated with waist and diastolic BP (both P &lt; 0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (odds ratios 0.48 (95% confidence intervals 0.36-0.64) highest versus lowest quintile. P-trend &lt; 0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for homeostasis model assessment of insulin resistance (0.60 (0.47-0.78) P-trend &lt; 0.001) There was no association between PTH and MetS. Conclusions: Our results demonstrate an inverse relationship between 25(OH)D levels and MetS, which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study},
  author       = {Lee, David M. and Rutter, Martin K. and O'Neill, Terrence W. and Boonen, Steven and Vandershueren, Dirk and Bouillon, Roger and Bartfai, Gyorgy and Casanueva, Felipe F. and Finn, Joseph D. and Forti, Gianni and Giwercman, Aleksander and Han, Thang S. and Huhtamemi, Ilpo T. and Kula, Krzysztof and Lean, Micheal E. J. and Pendleton, Neil and Punab, Margus and Silman, Alan J. and Hu, Frederick C. W.},
  issn         = {1479-683X},
  language     = {eng},
  number       = {6},
  pages        = {947--954},
  publisher    = {Society of the European Journal of Endocrinology},
  series       = {European Journal of Endocrinology1994-01-01+01:00},
  title        = {Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men},
  url          = {http://dx.doi.org/10.1530/EJE-09-0496},
  volume       = {161},
  year         = {2009},
}