Advanced

Neutrophil-derived heparin binding protein-A mediator of increased vascular permeability after burns?

Johansson, Joakim; Lindbom, Lennart; Herwald, Heiko LU and Sjoberg, Folke (2009) In Burns 35(8). p.1185-1187
Abstract
Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after major burns due to a systemic inflammatory response and investigated plasma-HBP concentrations in 10 severely burned patients daily for 1 week following the burn. Five-fold higher levels in plasma-HBP concentration compared to a control group were detected on the first day after injury, followed by a steep reduction in the time-period that... (More)
Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after major burns due to a systemic inflammatory response and investigated plasma-HBP concentrations in 10 severely burned patients daily for 1 week following the burn. Five-fold higher levels in plasma-HBP concentration compared to a control group were detected on the first day after injury, followed by a steep reduction in the time-period that corresponds to the last part of the hyperpermeability phase. These data are in accordance with the hypothesis that HBP may function as a mediator of the early bum-induced increase in vascular permeability, and call for further studies to confirm a possible cause-and-effect relationship between HBP and oedema formation following burns. (C) 2009 Elsevier Ltd and ISBI. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Vascular permeability, Trauma, HBP, CAP-37, Azurocidin, Burn
in
Burns
volume
35
issue
8
pages
1185 - 1187
publisher
Elsevier
external identifiers
  • wos:000272321400019
  • scopus:70350746694
ISSN
0305-4179
DOI
10.1016/j.burns.2009.02.021
language
English
LU publication?
yes
id
e0eb9c4e-3471-4a89-921a-9d5f29960109 (old id 1533601)
date added to LUP
2010-01-27 16:21:17
date last changed
2017-06-11 03:27:55
@article{e0eb9c4e-3471-4a89-921a-9d5f29960109,
  abstract     = {Increased vascular permeability and oedema formation constitute a major clinical challenge following burns. Several clinical studies show that leukocytes are systemically activated following burns. Neutrophils have the capability to increase vascular permeability via mechanisms thought to involve the release of heparin binding protein (HBP). We hypothesised that HBP is elevated in plasma after major burns due to a systemic inflammatory response and investigated plasma-HBP concentrations in 10 severely burned patients daily for 1 week following the burn. Five-fold higher levels in plasma-HBP concentration compared to a control group were detected on the first day after injury, followed by a steep reduction in the time-period that corresponds to the last part of the hyperpermeability phase. These data are in accordance with the hypothesis that HBP may function as a mediator of the early bum-induced increase in vascular permeability, and call for further studies to confirm a possible cause-and-effect relationship between HBP and oedema formation following burns. (C) 2009 Elsevier Ltd and ISBI. All rights reserved.},
  author       = {Johansson, Joakim and Lindbom, Lennart and Herwald, Heiko and Sjoberg, Folke},
  issn         = {0305-4179},
  keyword      = {Vascular permeability,Trauma,HBP,CAP-37,Azurocidin,Burn},
  language     = {eng},
  number       = {8},
  pages        = {1185--1187},
  publisher    = {Elsevier},
  series       = {Burns},
  title        = {Neutrophil-derived heparin binding protein-A mediator of increased vascular permeability after burns?},
  url          = {http://dx.doi.org/10.1016/j.burns.2009.02.021},
  volume       = {35},
  year         = {2009},
}