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The cerebellar microcircuit as an adaptive filter: experimental and computational evidence

Dean, Paul; Porrill, John; Ekerot, Carl-Fredrik LU and Jörntell, Henrik LU (2010) In Nature Reviews Neuroscience 11(1). p.30-43
Abstract
Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of... (More)
Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neuroscience
volume
11
issue
1
pages
30 - 43
publisher
Nature Publishing Group
external identifiers
  • wos:000272867600010
  • scopus:72849128126
ISSN
1471-003X
DOI
10.1038/nrn2756
language
English
LU publication?
yes
id
008e9032-ccbc-4dcf-ab45-98d073d846d3 (old id 1533804)
date added to LUP
2010-01-27 15:15:13
date last changed
2018-06-24 04:02:56
@article{008e9032-ccbc-4dcf-ab45-98d073d846d3,
  abstract     = {Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.},
  author       = {Dean, Paul and Porrill, John and Ekerot, Carl-Fredrik and Jörntell, Henrik},
  issn         = {1471-003X},
  language     = {eng},
  number       = {1},
  pages        = {30--43},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Neuroscience},
  title        = {The cerebellar microcircuit as an adaptive filter: experimental and computational evidence},
  url          = {http://dx.doi.org/10.1038/nrn2756},
  volume       = {11},
  year         = {2010},
}