The cerebellar microcircuit as an adaptive filter: experimental and computational evidence
(2010) In Nature Reviews Neuroscience 11(1). p.30-43- Abstract
- Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of... (More)
- Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1533804
- author
- Dean, Paul ; Porrill, John ; Ekerot, Carl-Fredrik LU and Jörntell, Henrik LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Neuroscience
- volume
- 11
- issue
- 1
- pages
- 30 - 43
- publisher
- Springer Nature
- external identifiers
-
- wos:000272867600010
- scopus:72849128126
- pmid:19997115
- ISSN
- 1471-003X
- DOI
- 10.1038/nrn2756
- language
- English
- LU publication?
- yes
- id
- 008e9032-ccbc-4dcf-ab45-98d073d846d3 (old id 1533804)
- date added to LUP
- 2016-04-01 13:13:39
- date last changed
- 2025-04-04 14:30:17
@article{008e9032-ccbc-4dcf-ab45-98d073d846d3,
abstract = {{Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.}},
author = {{Dean, Paul and Porrill, John and Ekerot, Carl-Fredrik and Jörntell, Henrik}},
issn = {{1471-003X}},
language = {{eng}},
number = {{1}},
pages = {{30--43}},
publisher = {{Springer Nature}},
series = {{Nature Reviews Neuroscience}},
title = {{The cerebellar microcircuit as an adaptive filter: experimental and computational evidence}},
url = {{http://dx.doi.org/10.1038/nrn2756}},
doi = {{10.1038/nrn2756}},
volume = {{11}},
year = {{2010}},
}