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Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports

Wurst, Friedrich Martin; Thon, Natasha; Aradottir, Steina LU ; Hartmann, Susanne; Wiesbeck, Gerhard Adam; Lesch, Otto; Skala, Katrin; Wolfersdorf, Manfred; Weinmann, Wolfgang and Alling, Christer LU (2010) In Addiction Biology 15(1). p.88-95
Abstract
Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol consumption. Fifty-seven alcohol-dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean... (More)
Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol consumption. Fifty-seven alcohol-dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean carbohydrate deficient transferrin (%CDT) was 8.68, and mean total ethanol intake in the last 7 days was 1653 g. PEth was measured in heparinized whole blood with a high-pressure liquid chromatography method, while GGT, MCV and %CDT were measured using routine methods. PEth levels at day 1 of detoxification ranged between 0.63 and 26.95 mu mol/l (6.22 mean, 4.70 median, SD 4.97). There were no false negatives at day 1. Sensitivities for the other biomarkers were 40.4% for MCV, 73.1% for GGT and 69.2% for %CDT, respectively. No gender differences were found for PEth levels at any time point. Our data suggest that PEth is (1) a suitable intermediate term marker of ethanol intake in both sexes; and (2) sensitivity is extraordinary high in alcohol dependent patients. The results add further evidence to the data that suggest that PEth has potential as a candidate for a sensitive and specific biomarker, which reflects longer-lasting intake of higher amounts of alcohol and seemingly has the above mentioned certain advantages over traditional biomarkers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
harmful ethanol intake, gamma glutamyl transpeptidase, gender aspects, mean corpuscular volume, phosphatidylethanol, sensitivity
in
Addiction Biology
volume
15
issue
1
pages
88 - 95
publisher
Wiley-Blackwell
external identifiers
  • wos:000272565100009
  • scopus:71949091346
ISSN
1369-1600
DOI
10.1111/j.1369-1600.2009.00185.x
language
English
LU publication?
yes
id
0480f69e-0d1a-4bbf-add0-b25cbff7b7bd (old id 1535654)
date added to LUP
2010-01-27 11:23:46
date last changed
2018-05-29 10:08:27
@article{0480f69e-0d1a-4bbf-add0-b25cbff7b7bd,
  abstract     = {Phosphatidylethanol (PEth) is a direct ethanol metabolite, and has recently attracted attention as biomarker of ethanol intake. The aims of the current study are: (1) to characterize the normalization time of PEth in larger samples than previously conducted; (2) to elucidate potential gender differences; and (3) to report the correlation of PEth with other biomarkers and self-reported alcohol consumption. Fifty-seven alcohol-dependent patients (ICD 10 F 10.25; 9 females, 48 males) entering medical detoxification at three study sites were enrolled. The study sample was comprised of 48 males and 9 females, with mean age 43.5. Mean gamma glutamyl transpeptidase (GGT) was 209.61 U/l, average mean corpuscular volume (MCV) was 97.35 fl, mean carbohydrate deficient transferrin (%CDT) was 8.68, and mean total ethanol intake in the last 7 days was 1653 g. PEth was measured in heparinized whole blood with a high-pressure liquid chromatography method, while GGT, MCV and %CDT were measured using routine methods. PEth levels at day 1 of detoxification ranged between 0.63 and 26.95 mu mol/l (6.22 mean, 4.70 median, SD 4.97). There were no false negatives at day 1. Sensitivities for the other biomarkers were 40.4% for MCV, 73.1% for GGT and 69.2% for %CDT, respectively. No gender differences were found for PEth levels at any time point. Our data suggest that PEth is (1) a suitable intermediate term marker of ethanol intake in both sexes; and (2) sensitivity is extraordinary high in alcohol dependent patients. The results add further evidence to the data that suggest that PEth has potential as a candidate for a sensitive and specific biomarker, which reflects longer-lasting intake of higher amounts of alcohol and seemingly has the above mentioned certain advantages over traditional biomarkers.},
  author       = {Wurst, Friedrich Martin and Thon, Natasha and Aradottir, Steina and Hartmann, Susanne and Wiesbeck, Gerhard Adam and Lesch, Otto and Skala, Katrin and Wolfersdorf, Manfred and Weinmann, Wolfgang and Alling, Christer},
  issn         = {1369-1600},
  keyword      = {harmful ethanol intake,gamma glutamyl transpeptidase,gender aspects,mean corpuscular volume,phosphatidylethanol,sensitivity},
  language     = {eng},
  number       = {1},
  pages        = {88--95},
  publisher    = {Wiley-Blackwell},
  series       = {Addiction Biology},
  title        = {Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports},
  url          = {http://dx.doi.org/10.1111/j.1369-1600.2009.00185.x},
  volume       = {15},
  year         = {2010},
}