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Evaluation of the measurement properties of symptom measurement instruments for atopic eczema : A systematic review

Gerbens, L. A A; Prinsen, C. A C; Chalmers, J. R.; Drucker, A. M.; von Kobyletzki, L. B. LU ; Limpens, J.; Nankervis, H.; Svensson, Åke LU ; Terwee, C. B. and Zhang, J., et al. (2017) In Allergy: European Journal of Allergy and Clinical Immunology 72(1). p.146-163
Abstract

Background: Symptoms have been identified as a core outcome domain for atopic eczema (AE) trials. Various instruments exist to measure symptoms in AE, but they vary in quality and there is a lack of standardization between clinical trials. Our objective was to systematically evaluate the quality of the evidence on the measurement properties of AE symptom instruments, thereby informing consensus discussions within the Harmonising Outcome Measures for Eczema (HOME) initiative regarding the most appropriate instruments for the core outcome domain symptoms. Methods: Using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist and predefined criteria for good measurement properties on identified... (More)

Background: Symptoms have been identified as a core outcome domain for atopic eczema (AE) trials. Various instruments exist to measure symptoms in AE, but they vary in quality and there is a lack of standardization between clinical trials. Our objective was to systematically evaluate the quality of the evidence on the measurement properties of AE symptom instruments, thereby informing consensus discussions within the Harmonising Outcome Measures for Eczema (HOME) initiative regarding the most appropriate instruments for the core outcome domain symptoms. Methods: Using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist and predefined criteria for good measurement properties on identified development and validation studies of AE symptom instruments, a best evidence synthesis was performed to draw an overall conclusion on quality of the instruments and to provide recommendations. Results: Eighteen instruments were identified and evaluated. When the quality and results of the studies were considered, only five of these instruments had sufficient validation data to consider them for the core outcome set for the core outcome domain symptoms. These were the paediatric Itch Severity Scale (ISS), Patient-Oriented Eczema Measure (POEM), Patient-Oriented SCOring Atopic Dermatitis (PO-SCORAD), Self-Administered Eczema Area and Severity Index (SA-EASI) and adapted SA-EASI. Conclusions: ISS (paediatric version), POEM, PO-SCORAD, SA-EASI and adapted SA-EASI are currently the most appropriate instruments and therefore have the potential to be recommended as core symptom instrument in future clinical trials. These findings will be utilized for the development of a core outcome set for AE.

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published
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keywords
Atopic eczema, Core outcome set, Harmonising Outcome Measures for Eczema (HOME) initiative, Measurement properties, Symptoms
in
Allergy: European Journal of Allergy and Clinical Immunology
volume
72
issue
1
pages
146 - 163
publisher
Wiley-Blackwell
external identifiers
  • scopus:84992493734
  • wos:000390798100016
ISSN
0105-4538
DOI
10.1111/all.12959
language
English
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yes
id
1535e452-a62c-4e94-964f-34937f1f9f05
date added to LUP
2016-11-16 16:17:42
date last changed
2018-01-07 11:35:34
@article{1535e452-a62c-4e94-964f-34937f1f9f05,
  abstract     = {<p>Background: Symptoms have been identified as a core outcome domain for atopic eczema (AE) trials. Various instruments exist to measure symptoms in AE, but they vary in quality and there is a lack of standardization between clinical trials. Our objective was to systematically evaluate the quality of the evidence on the measurement properties of AE symptom instruments, thereby informing consensus discussions within the Harmonising Outcome Measures for Eczema (HOME) initiative regarding the most appropriate instruments for the core outcome domain symptoms. Methods: Using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist and predefined criteria for good measurement properties on identified development and validation studies of AE symptom instruments, a best evidence synthesis was performed to draw an overall conclusion on quality of the instruments and to provide recommendations. Results: Eighteen instruments were identified and evaluated. When the quality and results of the studies were considered, only five of these instruments had sufficient validation data to consider them for the core outcome set for the core outcome domain symptoms. These were the paediatric Itch Severity Scale (ISS), Patient-Oriented Eczema Measure (POEM), Patient-Oriented SCOring Atopic Dermatitis (PO-SCORAD), Self-Administered Eczema Area and Severity Index (SA-EASI) and adapted SA-EASI. Conclusions: ISS (paediatric version), POEM, PO-SCORAD, SA-EASI and adapted SA-EASI are currently the most appropriate instruments and therefore have the potential to be recommended as core symptom instrument in future clinical trials. These findings will be utilized for the development of a core outcome set for AE.</p>},
  author       = {Gerbens, L. A A and Prinsen, C. A C and Chalmers, J. R. and Drucker, A. M. and von Kobyletzki, L. B. and Limpens, J. and Nankervis, H. and Svensson, Åke and Terwee, C. B. and Zhang, J. and Apfelbacher, C. J. and Spuls, P. I.},
  issn         = {0105-4538},
  keyword      = {Atopic eczema,Core outcome set,Harmonising Outcome Measures for Eczema (HOME) initiative,Measurement properties,Symptoms},
  language     = {eng},
  number       = {1},
  pages        = {146--163},
  publisher    = {Wiley-Blackwell},
  series       = {Allergy: European Journal of Allergy and Clinical Immunology},
  title        = {Evaluation of the measurement properties of symptom measurement instruments for atopic eczema : A systematic review},
  url          = {http://dx.doi.org/10.1111/all.12959},
  volume       = {72},
  year         = {2017},
}