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Release of model compounds from "plum-pudding"-type gels composed of microgel particles randomly dispersed in a gel matrix

Lynch, Iseult LU and Dawson, K A (2004) In The Journal of Physical Chemistry Part B 108(30). p.10893-10898
Abstract
A novel gel structure called the "plum-pudding" gel was described by us previously. I The gel was composed of randomly dispersed microgel particles ("plums") in a conventional hydrogel network. Depending on the preparation conditions, the microgels can be incorporated into the gel as expanded networks or dense collapsed globules. Where the microgel particles exist as collapsed globules, they have the potential to act as reservoirs for hydrophobic solutes, from which the solutes are released very slowly. The release of two model hydrophobic compounds (pyrene and BODIPY) from "plum-pudding" gels composed of 50:50 BAM:NIPAM microgels embedded in NIPA gel films was investigated. The release of pyrene was found to follow Fickian diffusion,... (More)
A novel gel structure called the "plum-pudding" gel was described by us previously. I The gel was composed of randomly dispersed microgel particles ("plums") in a conventional hydrogel network. Depending on the preparation conditions, the microgels can be incorporated into the gel as expanded networks or dense collapsed globules. Where the microgel particles exist as collapsed globules, they have the potential to act as reservoirs for hydrophobic solutes, from which the solutes are released very slowly. The release of two model hydrophobic compounds (pyrene and BODIPY) from "plum-pudding" gels composed of 50:50 BAM:NIPAM microgels embedded in NIPA gel films was investigated. The release of pyrene was found to follow Fickian diffusion, while the release of BODIPY was found to be slightly non-Fickian. Thus, we propose that by controlling the attractiveness of the microgel particles to the solutes to be released, a range of release profiles can be obtained from pure-Fickian to almost any conceivable time scale. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of Physical Chemistry Part B
volume
108
issue
30
pages
10893 - 10898
publisher
The American Chemical Society
external identifiers
  • wos:000222864200042
  • scopus:4043170064
ISSN
1520-5207
DOI
10.1021/jp0487105
language
English
LU publication?
yes
id
eb6e72c2-c24a-4939-a6b6-6699047055eb (old id 153939)
date added to LUP
2007-07-11 15:55:55
date last changed
2017-11-19 04:12:48
@article{eb6e72c2-c24a-4939-a6b6-6699047055eb,
  abstract     = {A novel gel structure called the "plum-pudding" gel was described by us previously. I The gel was composed of randomly dispersed microgel particles ("plums") in a conventional hydrogel network. Depending on the preparation conditions, the microgels can be incorporated into the gel as expanded networks or dense collapsed globules. Where the microgel particles exist as collapsed globules, they have the potential to act as reservoirs for hydrophobic solutes, from which the solutes are released very slowly. The release of two model hydrophobic compounds (pyrene and BODIPY) from "plum-pudding" gels composed of 50:50 BAM:NIPAM microgels embedded in NIPA gel films was investigated. The release of pyrene was found to follow Fickian diffusion, while the release of BODIPY was found to be slightly non-Fickian. Thus, we propose that by controlling the attractiveness of the microgel particles to the solutes to be released, a range of release profiles can be obtained from pure-Fickian to almost any conceivable time scale.},
  author       = {Lynch, Iseult and Dawson, K A},
  issn         = {1520-5207},
  language     = {eng},
  number       = {30},
  pages        = {10893--10898},
  publisher    = {The American Chemical Society},
  series       = {The Journal of Physical Chemistry Part B},
  title        = {Release of model compounds from "plum-pudding"-type gels composed of microgel particles randomly dispersed in a gel matrix},
  url          = {http://dx.doi.org/10.1021/jp0487105},
  volume       = {108},
  year         = {2004},
}