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Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia.

Cenci Nilsson, Angela LU ; Ohlin, Elisabet LU and Rylander, Daniella LU (2009) In Parkinsonism & Related Disorders 15 Suppl 3. p.59-63
Abstract
The development of L-DOPA-induced dyskinesia (LID) is attributed to plastic responses triggered by dopamine (DA) receptor stimulation in the parkinsonian brain. This article reviews studies that have uncovered different levels of maladaptive plasticity in animal models of LID. Rats developing dyskinesia on chronic L-DOPA treatment show abnormal patterns of signaling pathway activation and synaptic plasticity in striatal neurons. In addition, these animals show a gene expression profile indicative of structural cellular plasticity, including pronounced upregulation of genes involved in extracellular matrix remodeling, neurite extension, synaptic vesicle trafficking, and endothelial and cellular proliferation. Structural changes of neurons... (More)
The development of L-DOPA-induced dyskinesia (LID) is attributed to plastic responses triggered by dopamine (DA) receptor stimulation in the parkinsonian brain. This article reviews studies that have uncovered different levels of maladaptive plasticity in animal models of LID. Rats developing dyskinesia on chronic L-DOPA treatment show abnormal patterns of signaling pathway activation and synaptic plasticity in striatal neurons. In addition, these animals show a gene expression profile indicative of structural cellular plasticity, including pronounced upregulation of genes involved in extracellular matrix remodeling, neurite extension, synaptic vesicle trafficking, and endothelial and cellular proliferation. Structural changes of neurons and microvessels within the basal ganglia are currently being unraveled by detailed morphological analyses. The structural and functional adaptations induced by L-DOPA in the brain can be viewed as an attempt to meet increased metabolic demands and to boost cellular defense mechanisms. These homeostatic responses, however, also predispose to the appearance of dyskinesia and other complications during the course of the treatment. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Parkinsonism & Related Disorders
volume
15 Suppl 3
pages
59 - 63
publisher
Elsevier
external identifiers
  • pmid:20083009
  • scopus:71849091969
ISSN
1873-5126
DOI
10.1016/S1353-8020(09)70782-5
language
English
LU publication?
yes
id
45fc8c57-60d5-42d2-89e9-c7ffad6c63e7 (old id 1540487)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20083009?dopt=Abstract
date added to LUP
2010-02-04 21:00:17
date last changed
2017-11-19 04:18:33
@article{45fc8c57-60d5-42d2-89e9-c7ffad6c63e7,
  abstract     = {The development of L-DOPA-induced dyskinesia (LID) is attributed to plastic responses triggered by dopamine (DA) receptor stimulation in the parkinsonian brain. This article reviews studies that have uncovered different levels of maladaptive plasticity in animal models of LID. Rats developing dyskinesia on chronic L-DOPA treatment show abnormal patterns of signaling pathway activation and synaptic plasticity in striatal neurons. In addition, these animals show a gene expression profile indicative of structural cellular plasticity, including pronounced upregulation of genes involved in extracellular matrix remodeling, neurite extension, synaptic vesicle trafficking, and endothelial and cellular proliferation. Structural changes of neurons and microvessels within the basal ganglia are currently being unraveled by detailed morphological analyses. The structural and functional adaptations induced by L-DOPA in the brain can be viewed as an attempt to meet increased metabolic demands and to boost cellular defense mechanisms. These homeostatic responses, however, also predispose to the appearance of dyskinesia and other complications during the course of the treatment.},
  author       = {Cenci Nilsson, Angela and Ohlin, Elisabet and Rylander, Daniella},
  issn         = {1873-5126},
  language     = {eng},
  pages        = {59--63},
  publisher    = {Elsevier},
  series       = {Parkinsonism & Related Disorders},
  title        = {Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia.},
  url          = {http://dx.doi.org/10.1016/S1353-8020(09)70782-5},
  volume       = {15 Suppl 3},
  year         = {2009},
}