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Breast tomosynthesis: Accuracy of tumor measurement compared with digital mammography and ultrasonography.

Förnvik, Daniel LU ; Zackrisson, Sophia LU ; Ljungberg, Otto LU ; Svahn, Tony LU ; Timberg, Pontus LU ; Tingberg, Anders LU and Andersson, Ingvar LU (2010) In Acta radiologica (Stockholm, Sweden : 1987) 51. p.240-247
Abstract
Background: Mammographic tumor size measurement can be difficult because breast structures are superimposed onto a two-dimensional (2D) plane, potentially obscuring the tumor outline. Breast tomosynthesis (BT) is a 3D X-ray imaging technique in which low-dose images are acquired over a limited angular range at a total dose comparable to digital mammography (DM). These low-dose images are used to mathematically reconstruct a 3D image volume of the breast, thus reducing the problem of superimposed tissue. Purpose: To investigate whether breast cancer size can be more accurately assessed with breast tomosynthesis than with digital mammography and ultrasonography (US), by reducing the disturbance effect of the projected anatomy. Material and... (More)
Background: Mammographic tumor size measurement can be difficult because breast structures are superimposed onto a two-dimensional (2D) plane, potentially obscuring the tumor outline. Breast tomosynthesis (BT) is a 3D X-ray imaging technique in which low-dose images are acquired over a limited angular range at a total dose comparable to digital mammography (DM). These low-dose images are used to mathematically reconstruct a 3D image volume of the breast, thus reducing the problem of superimposed tissue. Purpose: To investigate whether breast cancer size can be more accurately assessed with breast tomosynthesis than with digital mammography and ultrasonography (US), by reducing the disturbance effect of the projected anatomy. Material and Methods: A prototype BT system was used. The main inclusion criterion for BT examination was subtle but suspicious findings of breast cancer on 2D mammography. Sixty-two women with 73 breast cancers were included. BT, DM, and US sizes were measured independently by experienced radiologists without knowledge of the pathology results, which were used as reference. Results: The tumor outline could be determined in significantly more cases with BT (63) and US (60) than DM (49). BT and US size correlated well with pathology (R=0.86 and R=0.85, respectively), and significantly better than DM size (R=0.71). Accordingly, staging was significantly more accurate with BT than with DM. Conclusion: The study indicates that BT is superior to DM in the assessment of breast tumor size and stage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta radiologica (Stockholm, Sweden : 1987)
volume
51
pages
240 - 247
publisher
John Wiley & Sons
external identifiers
  • wos:000275151700002
  • pmid:20105090
  • scopus:77749268123
ISSN
1600-0455
DOI
10.3109/02841850903524447
language
English
LU publication?
yes
id
7ee68173-b7f1-446d-9103-0a787a431360 (old id 1540543)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20105090?dopt=Abstract
date added to LUP
2010-02-04 20:01:46
date last changed
2017-08-27 05:49:23
@article{7ee68173-b7f1-446d-9103-0a787a431360,
  abstract     = {Background: Mammographic tumor size measurement can be difficult because breast structures are superimposed onto a two-dimensional (2D) plane, potentially obscuring the tumor outline. Breast tomosynthesis (BT) is a 3D X-ray imaging technique in which low-dose images are acquired over a limited angular range at a total dose comparable to digital mammography (DM). These low-dose images are used to mathematically reconstruct a 3D image volume of the breast, thus reducing the problem of superimposed tissue. Purpose: To investigate whether breast cancer size can be more accurately assessed with breast tomosynthesis than with digital mammography and ultrasonography (US), by reducing the disturbance effect of the projected anatomy. Material and Methods: A prototype BT system was used. The main inclusion criterion for BT examination was subtle but suspicious findings of breast cancer on 2D mammography. Sixty-two women with 73 breast cancers were included. BT, DM, and US sizes were measured independently by experienced radiologists without knowledge of the pathology results, which were used as reference. Results: The tumor outline could be determined in significantly more cases with BT (63) and US (60) than DM (49). BT and US size correlated well with pathology (R=0.86 and R=0.85, respectively), and significantly better than DM size (R=0.71). Accordingly, staging was significantly more accurate with BT than with DM. Conclusion: The study indicates that BT is superior to DM in the assessment of breast tumor size and stage.},
  author       = {Förnvik, Daniel and Zackrisson, Sophia and Ljungberg, Otto and Svahn, Tony and Timberg, Pontus and Tingberg, Anders and Andersson, Ingvar},
  issn         = {1600-0455},
  language     = {eng},
  pages        = {240--247},
  publisher    = {John Wiley & Sons},
  series       = {Acta radiologica (Stockholm, Sweden : 1987)},
  title        = {Breast tomosynthesis: Accuracy of tumor measurement compared with digital mammography and ultrasonography.},
  url          = {http://dx.doi.org/10.3109/02841850903524447},
  volume       = {51},
  year         = {2010},
}