Do microsatellites reflect genome-wide genetic diversity in natural populations? A comment on Väli et al. (2008).
(2010) In Molecular Ecology 19. p.851-855- Abstract
- Abstract A recent study by Väli et al. (2008) highlights that microsatellites will often provide a poor prediction of the genome-wide nucleotide diversity of wild populations, but does not fully explain why. To clarify and stress the importance of identity disequilibrium and marker variability for correlations between multilocus heterozygosity and genome-wide genetic variability, we performed a simple simulation with different types of markers, corresponding to microsatellites and SNPs, in populations with different inbreeding history. The importance of identity disequilibrium was apparent for both markers and there was a clear impact of marker variability.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1540592
- author
- Ljungqvist, Marcus
LU
; Åkesson, Mikael
LU
and Hansson, Bengt
LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- identity disequilibrium, genetic diversity, heterozygosity, inbreeding, microsatellites
- in
- Molecular Ecology
- volume
- 19
- pages
- 851 - 855
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000274550100003
- scopus:77953646255
- pmid:20102512
- ISSN
- 0962-1083
- DOI
- 10.1111/j.1365-294X.2010.04522.x
- language
- English
- LU publication?
- yes
- id
- f85082ef-f9d2-4851-883a-bd2eb90655b4 (old id 1540592)
- date added to LUP
- 2016-04-01 10:18:58
- date last changed
- 2024-01-06 13:37:47
@article{f85082ef-f9d2-4851-883a-bd2eb90655b4, abstract = {{Abstract A recent study by Väli et al. (2008) highlights that microsatellites will often provide a poor prediction of the genome-wide nucleotide diversity of wild populations, but does not fully explain why. To clarify and stress the importance of identity disequilibrium and marker variability for correlations between multilocus heterozygosity and genome-wide genetic variability, we performed a simple simulation with different types of markers, corresponding to microsatellites and SNPs, in populations with different inbreeding history. The importance of identity disequilibrium was apparent for both markers and there was a clear impact of marker variability.}}, author = {{Ljungqvist, Marcus and Åkesson, Mikael and Hansson, Bengt}}, issn = {{0962-1083}}, keywords = {{identity disequilibrium; genetic diversity; heterozygosity; inbreeding; microsatellites}}, language = {{eng}}, pages = {{851--855}}, publisher = {{Wiley-Blackwell}}, series = {{Molecular Ecology}}, title = {{Do microsatellites reflect genome-wide genetic diversity in natural populations? A comment on Väli et al. (2008).}}, url = {{http://dx.doi.org/10.1111/j.1365-294X.2010.04522.x}}, doi = {{10.1111/j.1365-294X.2010.04522.x}}, volume = {{19}}, year = {{2010}}, }