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Do microsatellites reflect genome-wide genetic diversity in natural populations? A comment on Väli et al. (2008).

Ljungqvist, Marcus LU ; Åkesson, Mikael LU and Hansson, Bengt LU (2010) In Molecular Ecology 19. p.851-855
Abstract
Abstract A recent study by Väli et al. (2008) highlights that microsatellites will often provide a poor prediction of the genome-wide nucleotide diversity of wild populations, but does not fully explain why. To clarify and stress the importance of identity disequilibrium and marker variability for correlations between multilocus heterozygosity and genome-wide genetic variability, we performed a simple simulation with different types of markers, corresponding to microsatellites and SNPs, in populations with different inbreeding history. The importance of identity disequilibrium was apparent for both markers and there was a clear impact of marker variability.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
identity disequilibrium, genetic diversity, heterozygosity, inbreeding, microsatellites
in
Molecular Ecology
volume
19
pages
851 - 855
publisher
Wiley-Blackwell
external identifiers
  • wos:000274550100003
  • scopus:77953646255
ISSN
0962-1083
DOI
10.1111/j.1365-294X.2010.04522.x
project
BECC
language
English
LU publication?
yes
id
f85082ef-f9d2-4851-883a-bd2eb90655b4 (old id 1540592)
date added to LUP
2010-02-10 12:33:12
date last changed
2018-05-29 09:48:04
@article{f85082ef-f9d2-4851-883a-bd2eb90655b4,
  abstract     = {Abstract A recent study by Väli et al. (2008) highlights that microsatellites will often provide a poor prediction of the genome-wide nucleotide diversity of wild populations, but does not fully explain why. To clarify and stress the importance of identity disequilibrium and marker variability for correlations between multilocus heterozygosity and genome-wide genetic variability, we performed a simple simulation with different types of markers, corresponding to microsatellites and SNPs, in populations with different inbreeding history. The importance of identity disequilibrium was apparent for both markers and there was a clear impact of marker variability.},
  author       = {Ljungqvist, Marcus and Åkesson, Mikael and Hansson, Bengt},
  issn         = {0962-1083},
  keyword      = {identity disequilibrium,genetic diversity,heterozygosity,inbreeding,microsatellites},
  language     = {eng},
  pages        = {851--855},
  publisher    = {Wiley-Blackwell},
  series       = {Molecular Ecology},
  title        = {Do microsatellites reflect genome-wide genetic diversity in natural populations? A comment on Väli et al. (2008).},
  url          = {http://dx.doi.org/10.1111/j.1365-294X.2010.04522.x},
  volume       = {19},
  year         = {2010},
}