Prolonged chemotherapy impairs liver regeneration after portal vein occlusion - An audit of 26 patients.
(2010) In European Journal of Surgical Oncology 36(4). p.358-364- Abstract
- AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chemotherapy. RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p... (More)
- AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chemotherapy. RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p = 0.04). Patients with tumour size greater than 60 mm showed a decreased degree of hypertrophy (7 +/- 1)% as compared to patients with smaller tumours (13 +/- 1%, p = 0.01). There was one death shortly after portal vein embolisation. 19/26 patients were resected with zero operative mortality. CONCLUSION: Prolonged neoadjuvant chemotherapy has a small negative effect on liver regeneration induced by portal vein occlusion. Liver regeneration induced by portal vein occlusion is relatively large when tumour burden is small. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1540611
- author
- Sturesson, Christian LU ; Keussen, Inger LU and Tranberg, K-G
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Surgical Oncology
- volume
- 36
- issue
- 4
- pages
- 358 - 364
- publisher
- Elsevier
- external identifiers
-
- wos:000276701900006
- pmid:20100648
- scopus:77949275733
- pmid:20100648
- ISSN
- 1532-2157
- DOI
- 10.1016/j.ejso.2009.12.001
- language
- English
- LU publication?
- yes
- id
- b78e5ea2-2c31-4f5f-8d68-5ec5bd9a82d1 (old id 1540611)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20100648?dopt=Abstract
- http://www.sciencedirect.com/science/article/pii/S0748798309005423
- date added to LUP
- 2016-04-04 08:54:06
- date last changed
- 2025-04-04 14:36:51
@article{b78e5ea2-2c31-4f5f-8d68-5ec5bd9a82d1,
abstract = {{AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chemotherapy. RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p = 0.04). Patients with tumour size greater than 60 mm showed a decreased degree of hypertrophy (7 +/- 1)% as compared to patients with smaller tumours (13 +/- 1%, p = 0.01). There was one death shortly after portal vein embolisation. 19/26 patients were resected with zero operative mortality. CONCLUSION: Prolonged neoadjuvant chemotherapy has a small negative effect on liver regeneration induced by portal vein occlusion. Liver regeneration induced by portal vein occlusion is relatively large when tumour burden is small.}},
author = {{Sturesson, Christian and Keussen, Inger and Tranberg, K-G}},
issn = {{1532-2157}},
language = {{eng}},
number = {{4}},
pages = {{358--364}},
publisher = {{Elsevier}},
series = {{European Journal of Surgical Oncology}},
title = {{Prolonged chemotherapy impairs liver regeneration after portal vein occlusion - An audit of 26 patients.}},
url = {{http://dx.doi.org/10.1016/j.ejso.2009.12.001}},
doi = {{10.1016/j.ejso.2009.12.001}},
volume = {{36}},
year = {{2010}},
}