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Prolonged chemotherapy impairs liver regeneration after portal vein occlusion - An audit of 26 patients.

Sturesson, Christian LU ; Keussen, Inger LU and Tranberg, K-G (2010) In European Journal of Surgical Oncology 36(4). p.358-364
Abstract
AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chemotherapy. RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p... (More)
AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chemotherapy. RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p = 0.04). Patients with tumour size greater than 60 mm showed a decreased degree of hypertrophy (7 +/- 1)% as compared to patients with smaller tumours (13 +/- 1%, p = 0.01). There was one death shortly after portal vein embolisation. 19/26 patients were resected with zero operative mortality. CONCLUSION: Prolonged neoadjuvant chemotherapy has a small negative effect on liver regeneration induced by portal vein occlusion. Liver regeneration induced by portal vein occlusion is relatively large when tumour burden is small. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Surgical Oncology
volume
36
issue
4
pages
358 - 364
publisher
Elsevier
external identifiers
  • wos:000276701900006
  • pmid:20100648
  • scopus:77949275733
ISSN
1532-2157
DOI
10.1016/j.ejso.2009.12.001
language
English
LU publication?
yes
id
b78e5ea2-2c31-4f5f-8d68-5ec5bd9a82d1 (old id 1540611)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20100648?dopt=Abstract
http://www.sciencedirect.com/science/article/pii/S0748798309005423
date added to LUP
2010-02-03 09:56:21
date last changed
2018-05-29 12:13:47
@article{b78e5ea2-2c31-4f5f-8d68-5ec5bd9a82d1,
  abstract     = {AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chemotherapy. RESULTS: After portal vein occlusion, the ratio of the future liver remnant volume to total parenchymal liver volume (FLR%) was reduced in patients receiving neoadjuvant chemotherapy (27 +/- 1% vs 32 +/- 1%, p = 0.03). A smaller future liver remnant before portal vein occlusion resulted in a greater degree of hypertrophy (r(2) = 0.18, p = 0.04). Patients with tumour size greater than 60 mm showed a decreased degree of hypertrophy (7 +/- 1)% as compared to patients with smaller tumours (13 +/- 1%, p = 0.01). There was one death shortly after portal vein embolisation. 19/26 patients were resected with zero operative mortality. CONCLUSION: Prolonged neoadjuvant chemotherapy has a small negative effect on liver regeneration induced by portal vein occlusion. Liver regeneration induced by portal vein occlusion is relatively large when tumour burden is small.},
  author       = {Sturesson, Christian and Keussen, Inger and Tranberg, K-G},
  issn         = {1532-2157},
  language     = {eng},
  number       = {4},
  pages        = {358--364},
  publisher    = {Elsevier},
  series       = {European Journal of Surgical Oncology},
  title        = {Prolonged chemotherapy impairs liver regeneration after portal vein occlusion - An audit of 26 patients.},
  url          = {http://dx.doi.org/10.1016/j.ejso.2009.12.001},
  volume       = {36},
  year         = {2010},
}