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Congenital malformations in infants born after in vitro fertilization in Sweden.

Källén, Bengt LU ; Finnström, Orvar; Lindam, Anna; Nilsson, Emma LU ; Nygren, Karl-Gösta and Otterblad, Petra Olausson (2010) In Birth Defects Research. Part A: Clinical and Molecular Teratology2003-01-01+01:002013-01-01+01:00 88. p.137-143
Abstract
BACKGROUND:: The risk for congenital malformations is increased in infants born after in vitro fertilization (IVF). Some specific malformations appear to be more affected than others. METHODS:: The presence of congenital malformations in 15,570 infants born after IVF with an embryo transfer between April 1, 2001, and the end of 2006 were compared with all infants born in Sweden during 2001 to 2007 (n = 689,157). Risk estimates were made after adjusting for year of birth, maternal age, parity, smoking, and body mass index. The risks of specific malformations were compared with data from a previous study (1982 to March 31, 2001) of 16,280 infants born after IVF. Different IVF methods were compared to respect to malformation risk. RESULTS::... (More)
BACKGROUND:: The risk for congenital malformations is increased in infants born after in vitro fertilization (IVF). Some specific malformations appear to be more affected than others. METHODS:: The presence of congenital malformations in 15,570 infants born after IVF with an embryo transfer between April 1, 2001, and the end of 2006 were compared with all infants born in Sweden during 2001 to 2007 (n = 689,157). Risk estimates were made after adjusting for year of birth, maternal age, parity, smoking, and body mass index. The risks of specific malformations were compared with data from a previous study (1982 to March 31, 2001) of 16,280 infants born after IVF. Different IVF methods were compared to respect to malformation risk. RESULTS:: Increased risks of a similar magnitude were found for most cardiovascular malformations and limb reduction defects for both study periods. For neural tube defects, cardiac septal defects, and esophageal atresia, there was still an increased risk, but it was lower during the second than during the first period. For small bowel atresia, anal atresia, and hypospadias, the risk increase observed during the first study period had disappeared during the second period. An increased risk was seen for some syndromes that have been associated with imprinting errors. No difference in malformation risk according to IVF method was apparent. CONCLUSIONS:: A slightly increased risk for congenital malformations after IVF persists. A decreasing risk is seen for some specific malformations, either true or the result of multiple testing. Birth Defects Research (Part A), 2010. (c) 2009 Wiley-Liss, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Birth Defects Research. Part A: Clinical and Molecular Teratology2003-01-01+01:002013-01-01+01:00
volume
88
pages
137 - 143
publisher
John Wiley & Sons
external identifiers
  • wos:000276125800001
  • pmid:20063307
  • scopus:77749246677
ISSN
1542-0760
DOI
10.1002/bdra.20645
language
English
LU publication?
yes
id
108fa81f-2cf0-4078-a050-d49455ee4cdb (old id 1541221)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20063307?dopt=Abstract
date added to LUP
2010-02-02 13:10:01
date last changed
2018-07-15 04:19:01
@article{108fa81f-2cf0-4078-a050-d49455ee4cdb,
  abstract     = {BACKGROUND:: The risk for congenital malformations is increased in infants born after in vitro fertilization (IVF). Some specific malformations appear to be more affected than others. METHODS:: The presence of congenital malformations in 15,570 infants born after IVF with an embryo transfer between April 1, 2001, and the end of 2006 were compared with all infants born in Sweden during 2001 to 2007 (n = 689,157). Risk estimates were made after adjusting for year of birth, maternal age, parity, smoking, and body mass index. The risks of specific malformations were compared with data from a previous study (1982 to March 31, 2001) of 16,280 infants born after IVF. Different IVF methods were compared to respect to malformation risk. RESULTS:: Increased risks of a similar magnitude were found for most cardiovascular malformations and limb reduction defects for both study periods. For neural tube defects, cardiac septal defects, and esophageal atresia, there was still an increased risk, but it was lower during the second than during the first period. For small bowel atresia, anal atresia, and hypospadias, the risk increase observed during the first study period had disappeared during the second period. An increased risk was seen for some syndromes that have been associated with imprinting errors. No difference in malformation risk according to IVF method was apparent. CONCLUSIONS:: A slightly increased risk for congenital malformations after IVF persists. A decreasing risk is seen for some specific malformations, either true or the result of multiple testing. Birth Defects Research (Part A), 2010. (c) 2009 Wiley-Liss, Inc.},
  author       = {Källén, Bengt and Finnström, Orvar and Lindam, Anna and Nilsson, Emma and Nygren, Karl-Gösta and Otterblad, Petra Olausson},
  issn         = {1542-0760},
  language     = {eng},
  pages        = {137--143},
  publisher    = {John Wiley & Sons},
  series       = {Birth Defects Research. Part A: Clinical and Molecular Teratology2003-01-01+01:002013-01-01+01:00},
  title        = {Congenital malformations in infants born after in vitro fertilization in Sweden.},
  url          = {http://dx.doi.org/10.1002/bdra.20645},
  volume       = {88},
  year         = {2010},
}