Using therapeutic cloning to fight human disease: A conundrum or reality?
(2006) In Stem Cells 24(7). p.1628-1637- Abstract
- The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. Furthermore, the implications of transferring mitochondrial heteroplasmic cells, which may harbor aberrant epigenetic gene expression profiles, are of concern. The production of human NT-ESC lines also remains plagued by ethical dilemmas, societal concerns, and controversies. Recently, a number of alternate therapeutic strategies have been proposed... (More)
- The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. Furthermore, the implications of transferring mitochondrial heteroplasmic cells, which may harbor aberrant epigenetic gene expression profiles, are of concern. The production of human NT-ESC lines also remains plagued by ethical dilemmas, societal concerns, and controversies. Recently, a number of alternate therapeutic strategies have been proposed to circumvent the moral implications surrounding human nuclear transfer. It will be critical to overcome these biological, legislative, and moral restraints to maximize the potential of this therapeutic strategy and to alleviate human disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/154434
- author
- Hall, Vanessa LU ; Stojkovic, Petra and Stojkovic, Miodrag
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Clinical stem cell transplantation, Reprogramming, Human embryonic stem cells, Cloning
- in
- Stem Cells
- volume
- 24
- issue
- 7
- pages
- 1628 - 1637
- publisher
- Oxford University Press
- external identifiers
-
- wos:000240639500001
- pmid:16556706
- scopus:33749048146
- ISSN
- 1549-4918
- DOI
- 10.1634/stemcells.2005-0592
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
- id
- b47c2a01-8d2f-40f6-bbea-5a4e438d8974 (old id 154434)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16556706&dopt=Abstract
- date added to LUP
- 2016-04-01 16:44:48
- date last changed
- 2023-01-05 01:55:47
@article{b47c2a01-8d2f-40f6-bbea-5a4e438d8974,
abstract = {{The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. Furthermore, the implications of transferring mitochondrial heteroplasmic cells, which may harbor aberrant epigenetic gene expression profiles, are of concern. The production of human NT-ESC lines also remains plagued by ethical dilemmas, societal concerns, and controversies. Recently, a number of alternate therapeutic strategies have been proposed to circumvent the moral implications surrounding human nuclear transfer. It will be critical to overcome these biological, legislative, and moral restraints to maximize the potential of this therapeutic strategy and to alleviate human disease.}},
author = {{Hall, Vanessa and Stojkovic, Petra and Stojkovic, Miodrag}},
issn = {{1549-4918}},
keywords = {{Clinical stem cell transplantation; Reprogramming; Human embryonic stem cells; Cloning}},
language = {{eng}},
number = {{7}},
pages = {{1628--1637}},
publisher = {{Oxford University Press}},
series = {{Stem Cells}},
title = {{Using therapeutic cloning to fight human disease: A conundrum or reality?}},
url = {{http://dx.doi.org/10.1634/stemcells.2005-0592}},
doi = {{10.1634/stemcells.2005-0592}},
volume = {{24}},
year = {{2006}},
}