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Using therapeutic cloning to fight human disease: A conundrum or reality?

Hall, Vanessa LU ; Stojkovic, Petra and Stojkovic, Miodrag (2006) In Stem Cells 24(7). p.1628-1637
Abstract
The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. Furthermore, the implications of transferring mitochondrial heteroplasmic cells, which may harbor aberrant epigenetic gene expression profiles, are of concern. The production of human NT-ESC lines also remains plagued by ethical dilemmas, societal concerns, and controversies. Recently, a number of alternate therapeutic strategies have been proposed... (More)
The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. Furthermore, the implications of transferring mitochondrial heteroplasmic cells, which may harbor aberrant epigenetic gene expression profiles, are of concern. The production of human NT-ESC lines also remains plagued by ethical dilemmas, societal concerns, and controversies. Recently, a number of alternate therapeutic strategies have been proposed to circumvent the moral implications surrounding human nuclear transfer. It will be critical to overcome these biological, legislative, and moral restraints to maximize the potential of this therapeutic strategy and to alleviate human disease. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Clinical stem cell transplantation, Reprogramming, Human embryonic stem cells, Cloning
in
Stem Cells
volume
24
issue
7
pages
1628 - 1637
publisher
AlphaMed Press
external identifiers
  • wos:000240639500001
  • pmid:16556706
  • scopus:33749048146
ISSN
1549-4918
DOI
10.1634/stemcells.2005-0592
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
b47c2a01-8d2f-40f6-bbea-5a4e438d8974 (old id 154434)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16556706&dopt=Abstract
date added to LUP
2016-04-01 16:44:48
date last changed
2021-02-17 01:13:59
@article{b47c2a01-8d2f-40f6-bbea-5a4e438d8974,
  abstract     = {The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. Furthermore, the implications of transferring mitochondrial heteroplasmic cells, which may harbor aberrant epigenetic gene expression profiles, are of concern. The production of human NT-ESC lines also remains plagued by ethical dilemmas, societal concerns, and controversies. Recently, a number of alternate therapeutic strategies have been proposed to circumvent the moral implications surrounding human nuclear transfer. It will be critical to overcome these biological, legislative, and moral restraints to maximize the potential of this therapeutic strategy and to alleviate human disease.},
  author       = {Hall, Vanessa and Stojkovic, Petra and Stojkovic, Miodrag},
  issn         = {1549-4918},
  language     = {eng},
  number       = {7},
  pages        = {1628--1637},
  publisher    = {AlphaMed Press},
  series       = {Stem Cells},
  title        = {Using therapeutic cloning to fight human disease: A conundrum or reality?},
  url          = {http://dx.doi.org/10.1634/stemcells.2005-0592},
  doi          = {10.1634/stemcells.2005-0592},
  volume       = {24},
  year         = {2006},
}