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Symptoms and aspects on eosinophil activity in allergic rhinitis

Ahlström-Emanuelsson, Cecilia LU (2010) In Lund University, Faculty of Medicine Doctoral Dissertation Series 2010:15.
Abstract
Allergic rhinitis is a major atopic disease. Even if much is known about the pathophysiology of this condition, and despite the fact that good treatments are available, there is a need for new treatment options, particularly for such aiming at new targets and reduced side effects.



Recruitment and activation of eosinophils is a key feature of allergic rhinitis. Eosinophils have different activation modes with subsequent mediator release. Before and during a natural birch pollen season we take nasal biopsies and utilize electron microscopy to assess eosinophil activity. We show that allergen exposure produces a marked increase in piecemeal degranulation and release of mediators (indicated by ECP).



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Allergic rhinitis is a major atopic disease. Even if much is known about the pathophysiology of this condition, and despite the fact that good treatments are available, there is a need for new treatment options, particularly for such aiming at new targets and reduced side effects.



Recruitment and activation of eosinophils is a key feature of allergic rhinitis. Eosinophils have different activation modes with subsequent mediator release. Before and during a natural birch pollen season we take nasal biopsies and utilize electron microscopy to assess eosinophil activity. We show that allergen exposure produces a marked increase in piecemeal degranulation and release of mediators (indicated by ECP).



Variations in onset, intensity, and duration of natural pollen exposure make it difficult to compare treatments in allergic rhinitis. To overcome this, we demonstrate that repeated individualized allergen challenges can produce symptoms and signs that mimic seasonal disease. We indicate the usefulness of the model by demonstrating dose-dependent symptom-reducing effects of a topical corticosteroid.



Preceding observations suggest that ß2-agonists may be treatment candidates for allergic inflammation. Utilizing the above-mentioned allergen challenge model, we examine whether or not a topical ß2-agonist (formoterol) affect eosinophilic inflammation in allergic rhinitis. We demonstrate that the ß2-agonist neither affects symptoms and eosinophilic inflammation in allergic rhinitis nor the efficacy of a topical corticosteroid.



Employing the allergen challenge model, and a topical corticosteroid as experimental tool, we demonstrate that production of the eosinophil chemokine CCL5 is particularly corticosteroid sensitive, suggesting that it may be a valid treatment target. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Associated Professor, MD,PhD Holmström, Mats, no
organization
publishing date
type
Thesis
publication status
published
subject
in
Lund University, Faculty of Medicine Doctoral Dissertation Series
volume
2010:15
pages
58 pages
publisher
Department of Otorhinolaryngology, Lund University
defense location
Belfragesalen BMC
defense date
2010-03-12 09:00
ISSN
1652-8220
ISBN
978-91-86443-29-0
language
English
LU publication?
yes
id
e19c7014-a39b-4150-9c83-34e8c4b9999c (old id 1545041)
date added to LUP
2010-02-22 11:38:35
date last changed
2018-05-29 11:34:01
@phdthesis{e19c7014-a39b-4150-9c83-34e8c4b9999c,
  abstract     = {Allergic rhinitis is a major atopic disease. Even if much is known about the pathophysiology of this condition, and despite the fact that good treatments are available, there is a need for new treatment options, particularly for such aiming at new targets and reduced side effects.<br/><br>
<br/><br>
Recruitment and activation of eosinophils is a key feature of allergic rhinitis. Eosinophils have different activation modes with subsequent mediator release. Before and during a natural birch pollen season we take nasal biopsies and utilize electron microscopy to assess eosinophil activity. We show that allergen exposure produces a marked increase in piecemeal degranulation and release of mediators (indicated by ECP).<br/><br>
<br/><br>
Variations in onset, intensity, and duration of natural pollen exposure make it difficult to compare treatments in allergic rhinitis. To overcome this, we demonstrate that repeated individualized allergen challenges can produce symptoms and signs that mimic seasonal disease. We indicate the usefulness of the model by demonstrating dose-dependent symptom-reducing effects of a topical corticosteroid.<br/><br>
<br/><br>
Preceding observations suggest that ß2-agonists may be treatment candidates for allergic inflammation. Utilizing the above-mentioned allergen challenge model, we examine whether or not a topical ß2-agonist (formoterol) affect eosinophilic inflammation in allergic rhinitis. We demonstrate that the ß2-agonist neither affects symptoms and eosinophilic inflammation in allergic rhinitis nor the efficacy of a topical corticosteroid. <br/><br>
<br/><br>
Employing the allergen challenge model, and a topical corticosteroid as experimental tool, we demonstrate that production of the eosinophil chemokine CCL5 is particularly corticosteroid sensitive, suggesting that it may be a valid treatment target.},
  author       = {Ahlström-Emanuelsson, Cecilia},
  isbn         = {978-91-86443-29-0},
  issn         = {1652-8220},
  language     = {eng},
  pages        = {58},
  publisher    = {Department of Otorhinolaryngology, Lund University},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral Dissertation Series},
  title        = {Symptoms and aspects on eosinophil activity in allergic rhinitis},
  volume       = {2010:15},
  year         = {2010},
}