Linalool - a significant contact sensitizer after air exposure
(2010) In Contact Dermatitis 62(1). p.32-41- Abstract
- Background: Linalool is a widely used fragrance terpene. Pure linalool is not allergenic or a very weak allergen, but autoxidizes on air exposure and the oxidation products can cause contact allergy. Oxidized (ox.) linalool has previously been patch tested at a concentration of 2.0% in petrolatum (pet.) in 1511 patients, and 1.3% positive patch test reactions were observed. Objective: To investigate the optimal patch test concentration for detection of contact allergy to ox. linalool. Methods: Four concentrations of ox. linalool (2.0%, 4.0%, 6.0%, 11.0% pet.) were tested in 3418 consecutive dermatitis patients. Results: Ox. linalool 2.0%, 4.0%, 6.0%, and 11.0% pet. detected positive patch test reactions in 0.83%, 3.2%, 5.3%, and 7.2% of... (More)
- Background: Linalool is a widely used fragrance terpene. Pure linalool is not allergenic or a very weak allergen, but autoxidizes on air exposure and the oxidation products can cause contact allergy. Oxidized (ox.) linalool has previously been patch tested at a concentration of 2.0% in petrolatum (pet.) in 1511 patients, and 1.3% positive patch test reactions were observed. Objective: To investigate the optimal patch test concentration for detection of contact allergy to ox. linalool. Methods: Four concentrations of ox. linalool (2.0%, 4.0%, 6.0%, 11.0% pet.) were tested in 3418 consecutive dermatitis patients. Results: Ox. linalool 2.0%, 4.0%, 6.0%, and 11.0% pet. detected positive patch test reactions in 0.83%, 3.2%, 5.3%, and 7.2% of the tested patients, respectively. The doubtful reactions increased with rising concentrations but relatively less, giving 5.1%, 6.4%, and 7.3% doubtful reactions, respectively, for ox. linalool 4.0%, 6.0%, and 11.0% pet. Few irritative reactions were seen. Conclusions: Raising the patch test concentration for ox. linalool gave a better detection of contact allergy, as many as 5-7% positive patch test reactions were detected. We suggest a patch test concentration of ox. linalool 6.0% pet. for future patch testing, giving a dose per unit area of 2.4 mg/cm(2) when 20 mg test substance is tested in small Finn Chambers (R). (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1547331
- author
- Christensson, Johanna Brared ; Matura, Mihaly ; Gruvberger, Birgitta LU ; Bruze, Magnus LU and Karlberg, Ann-Therese
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- patch, test concentration, patch testing, terpenes, oxidation products, linalool, hydroperoxides, fragrance allergy, dose per unit area, allergic contact dermatitis, autoxidation
- in
- Contact Dermatitis
- volume
- 62
- issue
- 1
- pages
- 32 - 41
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000273767400004
- scopus:74949115964
- ISSN
- 0105-1873
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 9ad569b6-be42-4239-ae1f-b888543fa4e5 (old id 1547331)
- date added to LUP
- 2016-04-01 11:12:27
- date last changed
- 2022-08-28 00:03:00
@article{9ad569b6-be42-4239-ae1f-b888543fa4e5,
abstract = {{Background: Linalool is a widely used fragrance terpene. Pure linalool is not allergenic or a very weak allergen, but autoxidizes on air exposure and the oxidation products can cause contact allergy. Oxidized (ox.) linalool has previously been patch tested at a concentration of 2.0% in petrolatum (pet.) in 1511 patients, and 1.3% positive patch test reactions were observed. Objective: To investigate the optimal patch test concentration for detection of contact allergy to ox. linalool. Methods: Four concentrations of ox. linalool (2.0%, 4.0%, 6.0%, 11.0% pet.) were tested in 3418 consecutive dermatitis patients. Results: Ox. linalool 2.0%, 4.0%, 6.0%, and 11.0% pet. detected positive patch test reactions in 0.83%, 3.2%, 5.3%, and 7.2% of the tested patients, respectively. The doubtful reactions increased with rising concentrations but relatively less, giving 5.1%, 6.4%, and 7.3% doubtful reactions, respectively, for ox. linalool 4.0%, 6.0%, and 11.0% pet. Few irritative reactions were seen. Conclusions: Raising the patch test concentration for ox. linalool gave a better detection of contact allergy, as many as 5-7% positive patch test reactions were detected. We suggest a patch test concentration of ox. linalool 6.0% pet. for future patch testing, giving a dose per unit area of 2.4 mg/cm(2) when 20 mg test substance is tested in small Finn Chambers (R).}},
author = {{Christensson, Johanna Brared and Matura, Mihaly and Gruvberger, Birgitta and Bruze, Magnus and Karlberg, Ann-Therese}},
issn = {{0105-1873}},
keywords = {{patch; test concentration; patch testing; terpenes; oxidation products; linalool; hydroperoxides; fragrance allergy; dose per unit area; allergic contact dermatitis; autoxidation}},
language = {{eng}},
number = {{1}},
pages = {{32--41}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Linalool - a significant contact sensitizer after air exposure}},
volume = {{62}},
year = {{2010}},
}