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The role of biomechanics in the initiation and progression of OA of the knee.

Englund, Martin LU (2010) In Baillière's Best Practice & Research: Clinical Rheumatology 24(1). p.39-46
Abstract
The knee is one of the most common joints affected by osteoarthritis (OA), frequently with clinical presentation by middle age or even earlier. Accumulating evidence supports that knee OA progression is often driven by biomechanical forces, and the pathological response of tissues to such forces leads to structural joint deterioration, knee symptoms and reduced function. Well-known biomechanical risk factors for progression include joint malalignment and meniscal tear. The high risk of OA after knee injury demonstrates the critical role of biomechanical factors also in incident disease in susceptible individuals. However, our knowledge of the contributing biomechanical mechanisms in the development of early disease and their order of... (More)
The knee is one of the most common joints affected by osteoarthritis (OA), frequently with clinical presentation by middle age or even earlier. Accumulating evidence supports that knee OA progression is often driven by biomechanical forces, and the pathological response of tissues to such forces leads to structural joint deterioration, knee symptoms and reduced function. Well-known biomechanical risk factors for progression include joint malalignment and meniscal tear. The high risk of OA after knee injury demonstrates the critical role of biomechanical factors also in incident disease in susceptible individuals. However, our knowledge of the contributing biomechanical mechanisms in the development of early disease and their order of significance is limited. Part of the problem is our current lack of understanding of early-stage OA, when it starts and how to define it. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Baillière's Best Practice & Research: Clinical Rheumatology
volume
24
issue
1
pages
39 - 46
publisher
Baillière Tindall
external identifiers
  • wos:000275418300005
  • pmid:20129198
  • scopus:74549210046
ISSN
1532-1770
DOI
10.1016/j.berh.2009.08.008
language
English
LU publication?
yes
id
09558961-75a6-4376-a654-088ea127755e (old id 1552982)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20129198?dopt=Abstract
date added to LUP
2010-03-02 15:14:52
date last changed
2018-08-12 04:14:27
@article{09558961-75a6-4376-a654-088ea127755e,
  abstract     = {The knee is one of the most common joints affected by osteoarthritis (OA), frequently with clinical presentation by middle age or even earlier. Accumulating evidence supports that knee OA progression is often driven by biomechanical forces, and the pathological response of tissues to such forces leads to structural joint deterioration, knee symptoms and reduced function. Well-known biomechanical risk factors for progression include joint malalignment and meniscal tear. The high risk of OA after knee injury demonstrates the critical role of biomechanical factors also in incident disease in susceptible individuals. However, our knowledge of the contributing biomechanical mechanisms in the development of early disease and their order of significance is limited. Part of the problem is our current lack of understanding of early-stage OA, when it starts and how to define it.},
  author       = {Englund, Martin},
  issn         = {1532-1770},
  language     = {eng},
  number       = {1},
  pages        = {39--46},
  publisher    = {Baillière Tindall},
  series       = {Baillière's Best Practice & Research: Clinical Rheumatology},
  title        = {The role of biomechanics in the initiation and progression of OA of the knee.},
  url          = {http://dx.doi.org/10.1016/j.berh.2009.08.008},
  volume       = {24},
  year         = {2010},
}