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The effect of crystallinity on strength development of alpha-TCP bone substitutes.

Camire, Christopher LU ; Nevsten, Pernilla LU ; Lidgren, Lars LU and McCarthy, Ian LU (2006) In Journal of Biomedical Materials Research. Part B - Applied Biomaterials 79B(1). p.159-165
Abstract
Alpha phase tricalcium phosphates (alpha-TCP) were produced using a solid-state reaction method and milled for various periods of time. The resulting four materials were alpha-TCPs, ranging in crystalline content. Powders were exposed to X-ray diffraction for material identification as well as for use in crystallinity and purity calculations. Powder particle size was investigated using laser diffraction. Materials were mixed with 2.5% Na2HPO4 solution to initiate the hydration of alpha-TCP to calcium-deficient hydroxyapatite (CDHA). Isothermal calorimetry was performed to observe thermal response of the powders over a period of time. During the reaction process, at various time points up to 216 h, the material was compression tested to... (More)
Alpha phase tricalcium phosphates (alpha-TCP) were produced using a solid-state reaction method and milled for various periods of time. The resulting four materials were alpha-TCPs, ranging in crystalline content. Powders were exposed to X-ray diffraction for material identification as well as for use in crystallinity and purity calculations. Powder particle size was investigated using laser diffraction. Materials were mixed with 2.5% Na2HPO4 solution to initiate the hydration of alpha-TCP to calcium-deficient hydroxyapatite (CDHA). Isothermal calorimetry was performed to observe thermal response of the powders over a period of time. During the reaction process, at various time points up to 216 h, the material was compression tested to observe strength development. Materials proved to be predominantly alpha phase, while amorphous content determined by XRD varied. Reactivity, as measured by isothermal calorimetry, varied with crystallinity of the alpha-TCP powder. Speed of strength development did not change except for the most finely ground powder. In addition, crystal size of the CDHA was changed only in the product formed from the most highly ground material. It is proposed that increasing reactivity of alpha-TCP cements does not result in a corresponding increase in rate of strength development until there is sufficient supersaturation to produce significant crystal nucleation. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calcium phosphate, reactivity, calcium-deficient hydroxyapatite, thermal properties/calorimetry, mechanical strength
in
Journal of Biomedical Materials Research. Part B - Applied Biomaterials
volume
79B
issue
1
pages
159 - 165
publisher
John Wiley and Sons
external identifiers
  • wos:000240724300022
  • scopus:33749258943
ISSN
1552-4981
DOI
10.1002/jbm.b.30526
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Polymer and Materials Chemistry (LTH) (011001041), Department of Orthopaedics (Lund) (013028000)
id
b1dae3ea-64ad-4760-b48a-80bfb30a211a (old id 155891)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16615072&dopt=Abstract
date added to LUP
2016-04-01 11:41:21
date last changed
2021-10-06 05:45:54
@article{b1dae3ea-64ad-4760-b48a-80bfb30a211a,
  abstract     = {Alpha phase tricalcium phosphates (alpha-TCP) were produced using a solid-state reaction method and milled for various periods of time. The resulting four materials were alpha-TCPs, ranging in crystalline content. Powders were exposed to X-ray diffraction for material identification as well as for use in crystallinity and purity calculations. Powder particle size was investigated using laser diffraction. Materials were mixed with 2.5% Na2HPO4 solution to initiate the hydration of alpha-TCP to calcium-deficient hydroxyapatite (CDHA). Isothermal calorimetry was performed to observe thermal response of the powders over a period of time. During the reaction process, at various time points up to 216 h, the material was compression tested to observe strength development. Materials proved to be predominantly alpha phase, while amorphous content determined by XRD varied. Reactivity, as measured by isothermal calorimetry, varied with crystallinity of the alpha-TCP powder. Speed of strength development did not change except for the most finely ground powder. In addition, crystal size of the CDHA was changed only in the product formed from the most highly ground material. It is proposed that increasing reactivity of alpha-TCP cements does not result in a corresponding increase in rate of strength development until there is sufficient supersaturation to produce significant crystal nucleation.},
  author       = {Camire, Christopher and Nevsten, Pernilla and Lidgren, Lars and McCarthy, Ian},
  issn         = {1552-4981},
  language     = {eng},
  number       = {1},
  pages        = {159--165},
  publisher    = {John Wiley and Sons},
  series       = {Journal of Biomedical Materials Research. Part B - Applied Biomaterials},
  title        = {The effect of crystallinity on strength development of alpha-TCP bone substitutes.},
  url          = {http://dx.doi.org/10.1002/jbm.b.30526},
  doi          = {10.1002/jbm.b.30526},
  volume       = {79B},
  year         = {2006},
}