Comorbidities in people with hand OA and their associations with pain severity and sensitization : Data from the longitudinal Nor-Hand study
(2023) In Osteoarthritis and Cartilage Open 5(3).- Abstract
Objective: To determine whether the comorbidity burden and co-existing comorbidities are cross-sectionally and/or longitudinally associated with pain and pain sensitization in a cohort study of people with hand OA. Design: We examined whether comorbidity burden and individual comorbidities based on the self-administered Comorbidity Index (range: 0–42) at baseline were associated with pain outcomes at baseline and 3 years follow-up. Pain outcomes included hand and overall bodily pain (range: 0–10) as well as pressure pain thresholds at the tibialis anterior muscle (kg/cm2) and temporal summation (distal radioulnar joint) as measures of central pain sensitization. We performed linear regression analyses adjusted for age, sex,... (More)
Objective: To determine whether the comorbidity burden and co-existing comorbidities are cross-sectionally and/or longitudinally associated with pain and pain sensitization in a cohort study of people with hand OA. Design: We examined whether comorbidity burden and individual comorbidities based on the self-administered Comorbidity Index (range: 0–42) at baseline were associated with pain outcomes at baseline and 3 years follow-up. Pain outcomes included hand and overall bodily pain (range: 0–10) as well as pressure pain thresholds at the tibialis anterior muscle (kg/cm2) and temporal summation (distal radioulnar joint) as measures of central pain sensitization. We performed linear regression analyses adjusted for age, sex, body mass index, physical exercise and education. Results: We included 300 and 196 participants in cross-sectional and longitudinal analyses, respectively. Using baseline data, the burden of comorbidities was associated with greater pain in hands (beta = 0.61, 95% CI 0.37, 0.85) and overall body (beta = 0.60, 95% CI 0.37, 0.87). Similar strength of associations was found between comorbidity burden (baseline) and follow-up pain. Among the individual comorbidities, back pain and depression were associated with nearly one unit higher pain score in hands and overall body at both baseline and follow-up. Only back pain was related to lower pressure pain thresholds at follow up (beta = −0.24, 95% CI −0.50, −0.001). Conclusion: People with hand OA and greater comorbidity burden, co-existing back pain or depression reported greater pain severity than their counterparts, also 3 years later. These results acknowledge the relevance of accounting for comorbidities in the pain experience in people with hand OA.
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- author
- Mulrooney, Elisabeth ; Neogi, Tuhina ; Dagfinrud, Hanne ; Hammer, Hilde Berner ; Pettersen, Pernille Steen ; Gløersen, Marthe ; Kvien, Tore K. ; Magnusson, Karin LU and Haugen, Ida K.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Comorbidity, Hand osteoarthritis, Osteoarthritis, Pain, Pain sensitization
- in
- Osteoarthritis and Cartilage Open
- volume
- 5
- issue
- 3
- article number
- 100367
- publisher
- Elsevier
- external identifiers
-
- pmid:37234862
- scopus:85162518496
- ISSN
- 2665-9131
- DOI
- 10.1016/j.ocarto.2023.100367
- language
- English
- LU publication?
- yes
- id
- 156250ef-7bf9-4ba2-b63d-ba9235ca16e1
- date added to LUP
- 2023-09-05 10:04:00
- date last changed
- 2024-04-20 02:33:07
@article{156250ef-7bf9-4ba2-b63d-ba9235ca16e1,
abstract = {{<p>Objective: To determine whether the comorbidity burden and co-existing comorbidities are cross-sectionally and/or longitudinally associated with pain and pain sensitization in a cohort study of people with hand OA. Design: We examined whether comorbidity burden and individual comorbidities based on the self-administered Comorbidity Index (range: 0–42) at baseline were associated with pain outcomes at baseline and 3 years follow-up. Pain outcomes included hand and overall bodily pain (range: 0–10) as well as pressure pain thresholds at the tibialis anterior muscle (kg/cm<sup>2</sup>) and temporal summation (distal radioulnar joint) as measures of central pain sensitization. We performed linear regression analyses adjusted for age, sex, body mass index, physical exercise and education. Results: We included 300 and 196 participants in cross-sectional and longitudinal analyses, respectively. Using baseline data, the burden of comorbidities was associated with greater pain in hands (beta = 0.61, 95% CI 0.37, 0.85) and overall body (beta = 0.60, 95% CI 0.37, 0.87). Similar strength of associations was found between comorbidity burden (baseline) and follow-up pain. Among the individual comorbidities, back pain and depression were associated with nearly one unit higher pain score in hands and overall body at both baseline and follow-up. Only back pain was related to lower pressure pain thresholds at follow up (beta = −0.24, 95% CI −0.50, −0.001). Conclusion: People with hand OA and greater comorbidity burden, co-existing back pain or depression reported greater pain severity than their counterparts, also 3 years later. These results acknowledge the relevance of accounting for comorbidities in the pain experience in people with hand OA.</p>}},
author = {{Mulrooney, Elisabeth and Neogi, Tuhina and Dagfinrud, Hanne and Hammer, Hilde Berner and Pettersen, Pernille Steen and Gløersen, Marthe and Kvien, Tore K. and Magnusson, Karin and Haugen, Ida K.}},
issn = {{2665-9131}},
keywords = {{Comorbidity; Hand osteoarthritis; Osteoarthritis; Pain; Pain sensitization}},
language = {{eng}},
number = {{3}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage Open}},
title = {{Comorbidities in people with hand OA and their associations with pain severity and sensitization : Data from the longitudinal Nor-Hand study}},
url = {{http://dx.doi.org/10.1016/j.ocarto.2023.100367}},
doi = {{10.1016/j.ocarto.2023.100367}},
volume = {{5}},
year = {{2023}},
}