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Is there a role for bone morphogenetic proteins in osteoporotic fractures?

Kanakaris, Nikolaos K.; Petsatodis, George; Tägil, Magnus LU and Giannoudis, Peter V. (2009) In Injury 40. p.21-26
Abstract
The central role of bone morphogenetic proteins (BMPs) in the remodelling process of the human skeleton has been identified in numerous experimental and clinical studies. BMPs appear to be key agents in the osteoblastic differentiation of mesenchymal stem cells, and more recent evidence implicates them with the cells of the osteoclastic lineage. BMP-2, BMP-4, BMP-6 and BMP-7 have been studied in the context of osteoporosis and have been associated with its pathophysiological pathways. The theoretical advantages of local or systemic treatment of osteoporotic fractures with BMPs include the potential of inducing a rapid increase in bone strength locally at the fractured area and systemically in the entire skeleton, as well as accelerating... (More)
The central role of bone morphogenetic proteins (BMPs) in the remodelling process of the human skeleton has been identified in numerous experimental and clinical studies. BMPs appear to be key agents in the osteoblastic differentiation of mesenchymal stem cells, and more recent evidence implicates them with the cells of the osteoclastic lineage. BMP-2, BMP-4, BMP-6 and BMP-7 have been studied in the context of osteoporosis and have been associated with its pathophysiological pathways. The theoretical advantages of local or systemic treatment of osteoporotic fractures with BMPs include the potential of inducing a rapid increase in bone strength locally at the fractured area and systemically in the entire skeleton, as well as accelerating the bone-healing period. Animal models of osteoporotic fractures suggested that the induction of new bone by local or systemic use of BMP-7 should be investigated as potential bone augmentation therapy to improve bone quality in symptomatic spinal osteoporosis. As our knowledge expands, new innovations may provide clinicians with advanced biologically-based therapies for the successful treatment of osteoporotic fractures. (C) 2009 Elsevier Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteoclasts, Osteoblasts, Fracture healing, BMPs, Osteoporosis
in
Injury
volume
40
pages
21 - 26
publisher
Elsevier
external identifiers
  • wos:000274724600006
  • scopus:77956022298
ISSN
1879-0267
language
English
LU publication?
yes
id
68313ef7-27fc-4663-8f97-88e1ccb5049b (old id 1567744)
date added to LUP
2010-03-24 16:22:23
date last changed
2017-07-23 04:29:53
@article{68313ef7-27fc-4663-8f97-88e1ccb5049b,
  abstract     = {The central role of bone morphogenetic proteins (BMPs) in the remodelling process of the human skeleton has been identified in numerous experimental and clinical studies. BMPs appear to be key agents in the osteoblastic differentiation of mesenchymal stem cells, and more recent evidence implicates them with the cells of the osteoclastic lineage. BMP-2, BMP-4, BMP-6 and BMP-7 have been studied in the context of osteoporosis and have been associated with its pathophysiological pathways. The theoretical advantages of local or systemic treatment of osteoporotic fractures with BMPs include the potential of inducing a rapid increase in bone strength locally at the fractured area and systemically in the entire skeleton, as well as accelerating the bone-healing period. Animal models of osteoporotic fractures suggested that the induction of new bone by local or systemic use of BMP-7 should be investigated as potential bone augmentation therapy to improve bone quality in symptomatic spinal osteoporosis. As our knowledge expands, new innovations may provide clinicians with advanced biologically-based therapies for the successful treatment of osteoporotic fractures. (C) 2009 Elsevier Ltd. All rights reserved.},
  author       = {Kanakaris, Nikolaos K. and Petsatodis, George and Tägil, Magnus and Giannoudis, Peter V.},
  issn         = {1879-0267},
  keyword      = {Osteoclasts,Osteoblasts,Fracture healing,BMPs,Osteoporosis},
  language     = {eng},
  pages        = {21--26},
  publisher    = {Elsevier},
  series       = {Injury},
  title        = {Is there a role for bone morphogenetic proteins in osteoporotic fractures?},
  volume       = {40},
  year         = {2009},
}