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New insights into the development of retinopathy of prematurity - importance of early weight gain

Hellstrom, A.; Ley, David LU ; Pupp, Ingrid LU ; Niklasson, A.; Smith, L.; Lofqvist, C. and Hard, A-L (2010) In Acta Pædiatrica 99(4). p.502-508
Abstract
Evidence is accumulating that one of the strongest predictors of retinopathy of prematurity (ROP), in addition to low gestational age, is poor weight gain during the first weeks of life. In infants born preterm, the retina is not fully vascularised. The more premature the child, the larger is the avascular area. In response to hypoxia, vascular endothelial growth factor (VEGF) is secreted. For appropriate VEGF-induced vessel growth, sufficient levels of insulin-like growth factor I (IGF-I) in serum are necessary. IGF-I is a peptide, related to nutrition supply, which is essential for both pre- and post-natal general growth as well as for growth of the retinal vasculature. In prematurely born infants, serum levels are closely related to... (More)
Evidence is accumulating that one of the strongest predictors of retinopathy of prematurity (ROP), in addition to low gestational age, is poor weight gain during the first weeks of life. In infants born preterm, the retina is not fully vascularised. The more premature the child, the larger is the avascular area. In response to hypoxia, vascular endothelial growth factor (VEGF) is secreted. For appropriate VEGF-induced vessel growth, sufficient levels of insulin-like growth factor I (IGF-I) in serum are necessary. IGF-I is a peptide, related to nutrition supply, which is essential for both pre- and post-natal general growth as well as for growth of the retinal vasculature. In prematurely born infants, serum levels are closely related to gestational age and are lower in more prematurely born infants. At preterm birth the placental supply of nutrients is lost, growth factors are suddenly reduced and general as well as vascular growth slows down or ceases. In addition, the relative hyperoxia of the extra-uterine milieu, together with supplemental oxygen, causes a regression of already developed retinal vessels. Postnatal growth retardation is a major problem in very preterm infants. Both poor early weight gain and low serum levels of IGF-I during the first weeks/months of life have been found to be correlated with severity of ROP. Conclusion: This review will focus on the mechanisms leading to ROP by exploring factors responsible for poor early weight gain and abnormal vascularisation of the eye of the preterm infant. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Retinopathy of prematurity, Weight gain
in
Acta Pædiatrica
volume
99
issue
4
pages
502 - 508
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000274951200012
  • scopus:77649197682
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2009.01568.x
language
English
LU publication?
yes
id
223b9b05-7df4-498a-bfad-644b693aa87d (old id 1568427)
date added to LUP
2010-03-23 12:45:06
date last changed
2018-05-29 10:14:07
@article{223b9b05-7df4-498a-bfad-644b693aa87d,
  abstract     = {Evidence is accumulating that one of the strongest predictors of retinopathy of prematurity (ROP), in addition to low gestational age, is poor weight gain during the first weeks of life. In infants born preterm, the retina is not fully vascularised. The more premature the child, the larger is the avascular area. In response to hypoxia, vascular endothelial growth factor (VEGF) is secreted. For appropriate VEGF-induced vessel growth, sufficient levels of insulin-like growth factor I (IGF-I) in serum are necessary. IGF-I is a peptide, related to nutrition supply, which is essential for both pre- and post-natal general growth as well as for growth of the retinal vasculature. In prematurely born infants, serum levels are closely related to gestational age and are lower in more prematurely born infants. At preterm birth the placental supply of nutrients is lost, growth factors are suddenly reduced and general as well as vascular growth slows down or ceases. In addition, the relative hyperoxia of the extra-uterine milieu, together with supplemental oxygen, causes a regression of already developed retinal vessels. Postnatal growth retardation is a major problem in very preterm infants. Both poor early weight gain and low serum levels of IGF-I during the first weeks/months of life have been found to be correlated with severity of ROP. Conclusion: This review will focus on the mechanisms leading to ROP by exploring factors responsible for poor early weight gain and abnormal vascularisation of the eye of the preterm infant.},
  author       = {Hellstrom, A. and Ley, David and Pupp, Ingrid and Niklasson, A. and Smith, L. and Lofqvist, C. and Hard, A-L},
  issn         = {1651-2227},
  keyword      = {Retinopathy of prematurity,Weight gain},
  language     = {eng},
  number       = {4},
  pages        = {502--508},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {New insights into the development of retinopathy of prematurity - importance of early weight gain},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2009.01568.x},
  volume       = {99},
  year         = {2010},
}