Human papillomaviruses in skin cancer and cervical cancer
(2010) In Lund University Faculty of Medicine Doctoral Dissertation Series 2010:40.- Abstract
- The causal relationship between persistent genital infections with human
papillomavirus (HPV) and development of cervical cancer is well established.
In contrast, the significance of infections with cutaneous HPV for development
of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated
whether seropositivity to cutaneous HPV is a marker for cutaneous HPV
infection and used high throughput HPV serology to investigate the risk for
developing NMSC in relation to seropositivity for cutaneous HPV infection and
PCR techniques to investigate the risk for NMSC in relation to presence of HPV
DNA in the skin. We have also investigated how different sexually... (More) - The causal relationship between persistent genital infections with human
papillomavirus (HPV) and development of cervical cancer is well established.
In contrast, the significance of infections with cutaneous HPV for development
of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated
whether seropositivity to cutaneous HPV is a marker for cutaneous HPV
infection and used high throughput HPV serology to investigate the risk for
developing NMSC in relation to seropositivity for cutaneous HPV infection and
PCR techniques to investigate the risk for NMSC in relation to presence of HPV
DNA in the skin. We have also investigated how different sexually transmitted
infections interact with HPV in the aetiology of cervical cancer.
Two of our NMSC studies were hospital-based case-control studies where
biopsies from skin tumours and healthy skin were analysed for presence of HPV
DNA and serum samples for presence of antibodies to 14 different HPV types.
The third NMSC study and the cervical cancer study were designed as prospective
biobank-based case-control studies where biobanks were linked to cancer
registries for identification of cancers that have occurred after donation of a
serum sample. For patients with cervix cancer also formalin-fixed paraffin embedded
tumour tissue was retrieved and tested for HPV DNA.
In the skin cancer studies, we found that both DNA and seropositivity to
HPV of genus beta species 2 associated with an increased risk for development of
squamous cell carcinoma (SCC) of the skin and that sun-exposure is a risk factor
for cutaneous HPV infection. In the cervical cancer study we found in addition
to the exposure to the oncogenic HPV type that is found in the cancer tissue,
that history of Chlamydia trachomatis stood out among the different sexually
transmitted infections as being associated with increased risk for cervical cancer,
suggesting that it may acts as a co-factor to HPV in cervical carcinogenesis. (Less) - Abstract (Swedish)
- Popular Abstract in Swedish
Papillomvirus (PV) är små virus som förmodligen infekterar alla däggdjur
samt fåglar. De papillomvirus som infekterar människa kallas humant papillomvirus
(HPV) och kan infektera antingen huden eller slemhinnor.
Att livmoderhalscancer orsakas av bestående infektion med HPV har varit
känt länge. Man har länge också misstänkt att HPV-infektioner i huden kan
orsaka icke-melanom hudcancer (NMSC) men orsakssambandet är inte bevisat.
I gruppen NMSC ingår i huvudsak diagnoserna skivepitelcancer (SCC) och
basalcellscancer (BCC). Vi har undersökt risken att utveckla NMSC om man
har en HPV-infektion i huden tillsammans med andra kända... (More) - Popular Abstract in Swedish
Papillomvirus (PV) är små virus som förmodligen infekterar alla däggdjur
samt fåglar. De papillomvirus som infekterar människa kallas humant papillomvirus
(HPV) och kan infektera antingen huden eller slemhinnor.
Att livmoderhalscancer orsakas av bestående infektion med HPV har varit
känt länge. Man har länge också misstänkt att HPV-infektioner i huden kan
orsaka icke-melanom hudcancer (NMSC) men orsakssambandet är inte bevisat.
I gruppen NMSC ingår i huvudsak diagnoserna skivepitelcancer (SCC) och
basalcellscancer (BCC). Vi har undersökt risken att utveckla NMSC om man
har en HPV-infektion i huden tillsammans med andra kända riskfaktorer för
hudcancer och om detektion av antikroppar mot HPV som infekterar huden
sammanfaller med förekomst av HPV-DNA i huden. Vi har även tittat på hur
sexuellt överförbara HPV-infektioner samverkar med andra faktorer, så som andra
infektioner och rökning, i utvecklingen av livmoderhalscancer.
Två av studierna om NMSC är designade som sjukhusbaserade fall-kontrollstudier
(individer som redan har en sjukdom jämförs med individer utan sjukdomen),
där vävnad från tumör och frisk hud analyserats för förekomst av HPVDNA
och serumprov testats för förekomst av antikroppar mot 14 olika HPVtyper.
En tredje NMSC-studie och en studie om livmoderhalscancer är båda
designade som prospektiva (framåtblickande) fall-kontroll-studier där biobanker
länkats till cancerregister för att identifiera individer med sjukdomen som lämnat
prov till biobanken. Inom varje biobank har kontroller sedan valts efter
matchning mot fallen (faktorer så som kön, ålder och tidpunkt för provtagning)
och serumprov från både fall och kontroller samlats in och analyserats. Från
fallen med livmoderhalscancer har även tumörvävnad testats för HPV-DNA.
Sammanfattningsvis fann vi att infektion i huden med HPV från genus beta
species 2 innebar en ökad risk att utveckla SCC i huden samt att förhöjd exponering
av huden för solljus var en riskfaktor för att få en HPV-infektion. För
livmoderhalscancer fann vi att om DNA-test och antikroppstest var positivt för samma HPV-typ ökade risken att utveckla livmoderhalscancer jämfört med om
man bara testats positiv för antikroppar eller om HPV-typerna inte överensstämde.
Att ha varit infekterad med Chlamydia trachomatis var också kopplat
till livmoderhalscancer och bidrar troligen till risken. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1581000
- author
- Andersson, Kristin LU
- supervisor
- opponent
-
- professor favre, michel, Pasteur Institute, Paris, France
- organization
-
- Institution of Laboratory Medicine, Medical Microbiolgy, Respiratory Pathogen Group-lup-obsolete (research group)
- EpiHealth: Epidemiology for Health
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Epidemiology (research group)
- Clinical Microbiology, Malmö (research group)
- publishing date
- 2010
- type
- Thesis
- publication status
- published
- subject
- keywords
- Human papillomavirus, serology co-factors, non-melanoma skin cancer
- in
- Lund University Faculty of Medicine Doctoral Dissertation Series
- volume
- 2010:40
- pages
- 64 pages
- publisher
- Department of Medical Microbiology, Lund University
- defense location
- lecturing hall pathology department, Malmö
- defense date
- 2010-04-22 09:00:00
- ISSN
- 1652-8220
- ISBN
- 978-91-86443-55-9
- language
- English
- LU publication?
- yes
- id
- dcdc1f34-9b8e-4cc9-91c3-6fa0ca51e33b (old id 1581000)
- date added to LUP
- 2016-04-01 14:02:57
- date last changed
- 2023-04-18 20:23:14
@phdthesis{dcdc1f34-9b8e-4cc9-91c3-6fa0ca51e33b, abstract = {{The causal relationship between persistent genital infections with human<br/><br> papillomavirus (HPV) and development of cervical cancer is well established.<br/><br> In contrast, the significance of infections with cutaneous HPV for development<br/><br> of non-melanoma skin cancer (NMSC) is not well understood. We have evaluated<br/><br> whether seropositivity to cutaneous HPV is a marker for cutaneous HPV<br/><br> infection and used high throughput HPV serology to investigate the risk for<br/><br> developing NMSC in relation to seropositivity for cutaneous HPV infection and<br/><br> PCR techniques to investigate the risk for NMSC in relation to presence of HPV<br/><br> DNA in the skin. We have also investigated how different sexually transmitted<br/><br> infections interact with HPV in the aetiology of cervical cancer.<br/><br> Two of our NMSC studies were hospital-based case-control studies where<br/><br> biopsies from skin tumours and healthy skin were analysed for presence of HPV<br/><br> DNA and serum samples for presence of antibodies to 14 different HPV types.<br/><br> The third NMSC study and the cervical cancer study were designed as prospective<br/><br> biobank-based case-control studies where biobanks were linked to cancer<br/><br> registries for identification of cancers that have occurred after donation of a<br/><br> serum sample. For patients with cervix cancer also formalin-fixed paraffin embedded<br/><br> tumour tissue was retrieved and tested for HPV DNA.<br/><br> In the skin cancer studies, we found that both DNA and seropositivity to<br/><br> HPV of genus beta species 2 associated with an increased risk for development of<br/><br> squamous cell carcinoma (SCC) of the skin and that sun-exposure is a risk factor<br/><br> for cutaneous HPV infection. In the cervical cancer study we found in addition<br/><br> to the exposure to the oncogenic HPV type that is found in the cancer tissue,<br/><br> that history of Chlamydia trachomatis stood out among the different sexually<br/><br> transmitted infections as being associated with increased risk for cervical cancer,<br/><br> suggesting that it may acts as a co-factor to HPV in cervical carcinogenesis.}}, author = {{Andersson, Kristin}}, isbn = {{978-91-86443-55-9}}, issn = {{1652-8220}}, keywords = {{Human papillomavirus; serology co-factors; non-melanoma skin cancer}}, language = {{eng}}, publisher = {{Department of Medical Microbiology, Lund University}}, school = {{Lund University}}, series = {{Lund University Faculty of Medicine Doctoral Dissertation Series}}, title = {{Human papillomaviruses in skin cancer and cervical cancer}}, url = {{https://lup.lub.lu.se/search/files/3742648/1581012.pdf}}, volume = {{2010:40}}, year = {{2010}}, }