Advanced

Intracranial manifestations in SAPHO syndrome: the first case report in literature.

Abul-Kasim, Kasim LU ; Nilsson, Tomas and Turesson, Carl LU (2012) In Rheumatology International 32(6). p.1797-1799
Abstract
A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malignant cell. Symptoms recurred and a lesion were again detected on radiological follow-up, but improvement occurred following treatment with antibiotics and biphosphonate, achieving a low inflammatory activity, reduction in CNS lesions and relative clinical well-being. This is a first report in literature about the central nervous system involvement... (More)
A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malignant cell. Symptoms recurred and a lesion were again detected on radiological follow-up, but improvement occurred following treatment with antibiotics and biphosphonate, achieving a low inflammatory activity, reduction in CNS lesions and relative clinical well-being. This is a first report in literature about the central nervous system involvement in a patient with SAPHO syndrome. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Rheumatology International
volume
32
issue
6
pages
1797 - 1799
publisher
Springer
external identifiers
  • wos:000305680300050
  • pmid:20352220
  • scopus:84863877507
ISSN
1437-160X
DOI
10.1007/s00296-010-1464-8
language
English
LU publication?
yes
id
d7e7eea2-4bc8-4550-a69e-2fd62684f2f4 (old id 1581424)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20352220?dopt=Abstract
date added to LUP
2010-04-07 13:54:08
date last changed
2017-10-22 04:23:48
@article{d7e7eea2-4bc8-4550-a69e-2fd62684f2f4,
  abstract     = {A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malignant cell. Symptoms recurred and a lesion were again detected on radiological follow-up, but improvement occurred following treatment with antibiotics and biphosphonate, achieving a low inflammatory activity, reduction in CNS lesions and relative clinical well-being. This is a first report in literature about the central nervous system involvement in a patient with SAPHO syndrome.},
  author       = {Abul-Kasim, Kasim and Nilsson, Tomas and Turesson, Carl},
  issn         = {1437-160X},
  language     = {eng},
  number       = {6},
  pages        = {1797--1799},
  publisher    = {Springer},
  series       = {Rheumatology International},
  title        = {Intracranial manifestations in SAPHO syndrome: the first case report in literature.},
  url          = {http://dx.doi.org/10.1007/s00296-010-1464-8},
  volume       = {32},
  year         = {2012},
}