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Ubiquitin chain cleavage: CYLD at work.

Massoumi, Ramin LU (2010) In Trends in Biochemical Sciences 35. p.392-399
Abstract
The tumor suppressor CYLD is a deubiquitylating enzyme that negatively regulates different signaling pathways by removing lysine 63-linked polyubiquitin chains from several specific substrates. In various tumor types, CYLD loss can lead to cell survival or cell proliferation. In addition to its loss due to mutations, CYLD expression can also be decreased through transcriptional and post-transcriptional regulatory mechanisms. Moreover, as epigenetic repression of CYLD can affect tumor progression in different cancer types, the activation of the CYLD promoter ensures the tight control of an inflammatory response. Recent work also shows that CYLD activity can be governed by different regulatory mechanisms including phosphorylation, thus... (More)
The tumor suppressor CYLD is a deubiquitylating enzyme that negatively regulates different signaling pathways by removing lysine 63-linked polyubiquitin chains from several specific substrates. In various tumor types, CYLD loss can lead to cell survival or cell proliferation. In addition to its loss due to mutations, CYLD expression can also be decreased through transcriptional and post-transcriptional regulatory mechanisms. Moreover, as epigenetic repression of CYLD can affect tumor progression in different cancer types, the activation of the CYLD promoter ensures the tight control of an inflammatory response. Recent work also shows that CYLD activity can be governed by different regulatory mechanisms including phosphorylation, thus providing another layer of control for diverse physiological processes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Biochemical Sciences
volume
35
pages
392 - 399
publisher
Elsevier
external identifiers
  • wos:000280051600005
  • pmid:20347313
  • scopus:77954310807
ISSN
0167-7640
DOI
10.1016/j.tibs.2010.02.007
language
English
LU publication?
yes
id
c1e2e6f0-3155-4595-9b57-1dc9372590fc (old id 1581534)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20347313?dopt=Abstract
date added to LUP
2010-04-07 14:31:31
date last changed
2018-06-24 04:47:23
@article{c1e2e6f0-3155-4595-9b57-1dc9372590fc,
  abstract     = {The tumor suppressor CYLD is a deubiquitylating enzyme that negatively regulates different signaling pathways by removing lysine 63-linked polyubiquitin chains from several specific substrates. In various tumor types, CYLD loss can lead to cell survival or cell proliferation. In addition to its loss due to mutations, CYLD expression can also be decreased through transcriptional and post-transcriptional regulatory mechanisms. Moreover, as epigenetic repression of CYLD can affect tumor progression in different cancer types, the activation of the CYLD promoter ensures the tight control of an inflammatory response. Recent work also shows that CYLD activity can be governed by different regulatory mechanisms including phosphorylation, thus providing another layer of control for diverse physiological processes.},
  author       = {Massoumi, Ramin},
  issn         = {0167-7640},
  language     = {eng},
  pages        = {392--399},
  publisher    = {Elsevier},
  series       = {Trends in Biochemical Sciences},
  title        = {Ubiquitin chain cleavage: CYLD at work.},
  url          = {http://dx.doi.org/10.1016/j.tibs.2010.02.007},
  volume       = {35},
  year         = {2010},
}