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Prion-like transmission of protein aggregates in neurodegenerative diseases.

Brundin, Patrik LU ; Melki, Ronald and Kopito, Ron (2010) In Nature Reviews. Molecular Cell Biology 11(4). p.301-307
Abstract
Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews. Molecular Cell Biology
volume
11
issue
4
pages
301 - 307
publisher
Nature Publishing Group
external identifiers
  • wos:000275850400014
  • pmid:20308987
  • scopus:77949848854
  • pmid:20308987
ISSN
1471-0072
DOI
10.1038/nrm2873
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)
id
e3d2eb2d-a4fb-4801-a0b0-93f602537897 (old id 1581754)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20308987?dopt=Abstract
date added to LUP
2016-04-04 09:44:20
date last changed
2020-10-11 06:22:16
@article{e3d2eb2d-a4fb-4801-a0b0-93f602537897,
  abstract     = {Neurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and can directly contribute to the propagation of neurodegenerative disease pathogenesis. We propose that, once initiated, neuropathological changes might spread in a 'prion-like' manner and that disease progression is associated with the intercellular transfer of pathogenic proteins. The transfer of naked infectious particles between cells could therefore be a target for new disease-modifying therapies.},
  author       = {Brundin, Patrik and Melki, Ronald and Kopito, Ron},
  issn         = {1471-0072},
  language     = {eng},
  number       = {4},
  pages        = {301--307},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews. Molecular Cell Biology},
  title        = {Prion-like transmission of protein aggregates in neurodegenerative diseases.},
  url          = {http://dx.doi.org/10.1038/nrm2873},
  doi          = {10.1038/nrm2873},
  volume       = {11},
  year         = {2010},
}