HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.

Bakhtadze, Ekaterine; Borg, Henrik; Stenstrom, G; Fernlund, Per; Arnqvist, H; Ekbom-Schnell, A; Bolinder, J; Eriksson, J; Gudbjornsdottir, S; Nystrom, L; Groop, Leif; Sundkvist, Göran

HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.

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Bakhtadze, Ekaterine ^LU ; Borg, Henrik ^LU ; Stenstrom, G ; Fernlund, Per ^LU ; Arnqvist, H ; Ekbom-Schnell, A ; Bolinder, J ; Eriksson, J ; Gudbjornsdottir, S and Nystrom, L , et al. (2006) In Diabetologia 49(May 31). p.1785-1794

Abstract: The World Health Organization considers an aetiological classification of diabetes to be essential. The aim of this study was to evaluate whether HLA-DQB1 genotypes facilitate the classification of diabetes as compared with assessment of islet antibodies by investigating young adult diabetic patients. Blood samples were available at diagnosis for 1,872 (90%) of the 2,077 young adult patients (aged 15-34 years old) over a 5-year period in the nationwide Diabetes Incidence Study in Sweden. Islet antibodies were measured at diagnosis in 1,869 patients, fasting plasma C-peptide (fpC-peptide) after diagnosis in 1,522, while HLA-DQB1 genotypes were determined in 1,743. Islet antibodies were found in 83% of patients clinically considered to have... (More); The World Health Organization considers an aetiological classification of diabetes to be essential. The aim of this study was to evaluate whether HLA-DQB1 genotypes facilitate the classification of diabetes as compared with assessment of islet antibodies by investigating young adult diabetic patients. Blood samples were available at diagnosis for 1,872 (90%) of the 2,077 young adult patients (aged 15-34 years old) over a 5-year period in the nationwide Diabetes Incidence Study in Sweden. Islet antibodies were measured at diagnosis in 1,869 patients, fasting plasma C-peptide (fpC-peptide) after diagnosis in 1,522, while HLA-DQB1 genotypes were determined in 1,743. Islet antibodies were found in 83% of patients clinically considered to have type 1 diabetes, 23% with type 2 diabetes and 45% with unclassifiable diabetes. After diagnosis, median fpC-peptide concentrations were markedly lower in patients with islet antibodies than in those without (0.24 vs 0.69 nmol/l, p < 0.0001). Irrespective of clinical classification, patients with islet antibodies showed increased frequencies of at least one of the risk-associated HLA-DQB1 genotypes compared with patients without. Antibody-negative patients with risk-associated HLA-DQB1 genotypes had significantly lower median fpC-peptide concentrations than those without risk-associated genotypes (0.51 vs 0.74 nmol/l, p=0.0003). Assessment of islet antibodies is necessary for the aetiological classification of diabetic patients. HLA-DQB1 genotyping does not improve the classification in patients with islet antibodies. However, in patients without islet antibodies, HLA-DQB1 genotyping together with C-peptide measurement may be of value in differentiating between idiopathic type 1 diabetes and type 2 diabetes. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/158242

author

Bakhtadze, Ekaterine ^LU ; Borg, Henrik ^LU ; Stenstrom, G ; Fernlund, Per ^LU ; Arnqvist, H ; Ekbom-Schnell, A ; Bolinder, J ; Eriksson, J ; Gudbjornsdottir, S and Nystrom, L , et al. (More)

Bakhtadze, Ekaterine ^LU ; Borg, Henrik ^LU ; Stenstrom, G ; Fernlund, Per ^LU ; Arnqvist, H ; Ekbom-Schnell, A ; Bolinder, J ; Eriksson, J ; Gudbjornsdottir, S ; Nystrom, L ; Groop, Leif ^LU and Sundkvist, Göran ^LU (Less)

organization

publishing date

2006

type

Contribution to journal

publication status

published

subject

Endocrinology and Diabetes

keywords

C-peptide, islet antibodies, HLA-DQB1 genotypes, classification

in

Diabetologia

volume

49

issue

May 31

pages

1785 - 1794

publisher

Springer

external identifiers

wos:000238859900011
pmid:16783473
scopus:33745771093

ISSN

1432-0428

DOI

10.1007/s00125-006-0293-5

language

English

LU publication?

yes

additional info

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Chemistry, Malmö (013016000), Department of Translational Medicine (013017500), Diabetes and Endocrinology (013241530), Medicine (Lund) (013230025), Diabetes Epidemiology and Neuropathy (013241560)

id

e205987c-8c80-46ec-9e37-ee36e674c07c (old id 158242)

alternative location

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16783473&dopt=Abstract

date added to LUP

2016-04-01 11:48:42

date last changed

2024-01-07 21:25:29

@article{e205987c-8c80-46ec-9e37-ee36e674c07c,
  abstract     = {{The World Health Organization considers an aetiological classification of diabetes to be essential. The aim of this study was to evaluate whether HLA-DQB1 genotypes facilitate the classification of diabetes as compared with assessment of islet antibodies by investigating young adult diabetic patients. Blood samples were available at diagnosis for 1,872 (90%) of the 2,077 young adult patients (aged 15-34 years old) over a 5-year period in the nationwide Diabetes Incidence Study in Sweden. Islet antibodies were measured at diagnosis in 1,869 patients, fasting plasma C-peptide (fpC-peptide) after diagnosis in 1,522, while HLA-DQB1 genotypes were determined in 1,743. Islet antibodies were found in 83% of patients clinically considered to have type 1 diabetes, 23% with type 2 diabetes and 45% with unclassifiable diabetes. After diagnosis, median fpC-peptide concentrations were markedly lower in patients with islet antibodies than in those without (0.24 vs 0.69 nmol/l, p &lt; 0.0001). Irrespective of clinical classification, patients with islet antibodies showed increased frequencies of at least one of the risk-associated HLA-DQB1 genotypes compared with patients without. Antibody-negative patients with risk-associated HLA-DQB1 genotypes had significantly lower median fpC-peptide concentrations than those without risk-associated genotypes (0.51 vs 0.74 nmol/l, p=0.0003). Assessment of islet antibodies is necessary for the aetiological classification of diabetic patients. HLA-DQB1 genotyping does not improve the classification in patients with islet antibodies. However, in patients without islet antibodies, HLA-DQB1 genotyping together with C-peptide measurement may be of value in differentiating between idiopathic type 1 diabetes and type 2 diabetes.}},
  author       = {{Bakhtadze, Ekaterine and Borg, Henrik and Stenstrom, G and Fernlund, Per and Arnqvist, H and Ekbom-Schnell, A and Bolinder, J and Eriksson, J and Gudbjornsdottir, S and Nystrom, L and Groop, Leif and Sundkvist, Göran}},
  issn         = {{1432-0428}},
  keywords     = {{C-peptide; islet antibodies; HLA-DQB1 genotypes; classification}},
  language     = {{eng}},
  number       = {{May 31}},
  pages        = {{1785--1794}},
  publisher    = {{Springer}},
  series       = {{Diabetologia}},
  title        = {{HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.}},
  url          = {{https://lup.lub.lu.se/search/files/2652429/625498.pdf}},
  doi          = {{10.1007/s00125-006-0293-5}},
  volume       = {{49}},
  year         = {{2006}},
}

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HLA-DQB1 genotypes, islet antibodies and beta cell function in the classification of recent-onset diabetes among young adults in the nationwide Diabetes Incidence Study in Sweden.