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Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD) : A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups

Dominguez Perez, Sophia ; Phillips, Jeffrey S. ; Norise, Catherine ; Kinney, Nikolas G. ; Vaddi, Prerana ; Halpin, Amy ; Rascovsky, Katya ; Irwin, David J. ; McMillan, Corey T. and Xie, Long , et al. (2022) In Journal of Alzheimer's Disease 89(2). p.641-658
Abstract

Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, and 26 healthy controls. Neuropsychological assessment and MRI data were compared between these groups. Results: Compared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more... (More)

Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, and 26 healthy controls. Neuropsychological assessment and MRI data were compared between these groups. Results: Compared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more irritability (Neuropsychological Inventory), and equivalent verbal memory (Philadelphia Verbal Learning Test). Compared to aAD, bvAD indicated more executive dysfunction (F-letter fluency) and better visuospatial performance. Neuroimaging analysis found that bvAD showed cortical thinning relative to bvFTD posteriorly in left temporal-occipital regions; bvFTD had cortical thinning relative to bvAD in left inferior frontal cortex. bvAD had cortical thinning relative to aAD in prefrontal and anterior temporal regions. All patient groups had lower volumes than controls in both anterior and posterior hippocampus. However, bvAD patients had higher average volume than aAD patients in posterior hippocampus and higher volume than bvFTD patients in anterior hippocampus after adjustment for age and intracranial volume. Conclusion: Findings demonstrated that underlying pathology mediates disease presentation in bvAD and bvFTD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, behavioral, behavioral variant frontotemporal dementia, cognitive domains, cortical thinning, frontal variant, hippocampal volumes, neuropsychiatric symptoms
in
Journal of Alzheimer's Disease
volume
89
issue
2
pages
18 pages
publisher
IOS Press
external identifiers
  • scopus:85138209643
  • pmid:35938245
ISSN
1387-2877
DOI
10.3233/JAD-215728
language
English
LU publication?
yes
id
15827055-3461-44c7-a0ac-1a4f70e40f3e
date added to LUP
2022-12-02 11:07:31
date last changed
2024-06-14 16:49:49
@article{15827055-3461-44c7-a0ac-1a4f70e40f3e,
  abstract     = {{<p>Background: An understudied variant of Alzheimer's disease (AD), the behavioral/dysexecutive variant of AD (bvAD), is associated with progressive personality, behavior, and/or executive dysfunction and frontal atrophy. Objective: This study characterizes the neuropsychological and neuroanatomical features associated with bvAD by comparing it to behavioral variant frontotemporal dementia (bvFTD), amnestic AD (aAD), and subjects with normal cognition. Methods: Subjects included 16 bvAD, 67 bvFTD, 18 aAD patients, and 26 healthy controls. Neuropsychological assessment and MRI data were compared between these groups. Results: Compared to bvFTD, bvAD showed more significant visuospatial impairments (Rey Figure copy and recall), more irritability (Neuropsychological Inventory), and equivalent verbal memory (Philadelphia Verbal Learning Test). Compared to aAD, bvAD indicated more executive dysfunction (F-letter fluency) and better visuospatial performance. Neuroimaging analysis found that bvAD showed cortical thinning relative to bvFTD posteriorly in left temporal-occipital regions; bvFTD had cortical thinning relative to bvAD in left inferior frontal cortex. bvAD had cortical thinning relative to aAD in prefrontal and anterior temporal regions. All patient groups had lower volumes than controls in both anterior and posterior hippocampus. However, bvAD patients had higher average volume than aAD patients in posterior hippocampus and higher volume than bvFTD patients in anterior hippocampus after adjustment for age and intracranial volume. Conclusion: Findings demonstrated that underlying pathology mediates disease presentation in bvAD and bvFTD.</p>}},
  author       = {{Dominguez Perez, Sophia and Phillips, Jeffrey S. and Norise, Catherine and Kinney, Nikolas G. and Vaddi, Prerana and Halpin, Amy and Rascovsky, Katya and Irwin, David J. and McMillan, Corey T. and Xie, Long and Wisse, Laura E.M. and Yushkevich, Paul A. and Kallogjeri, Dorina and Grossman, Murray and Cousins, Katheryn A.Q.}},
  issn         = {{1387-2877}},
  keywords     = {{Alzheimer's disease; behavioral; behavioral variant frontotemporal dementia; cognitive domains; cortical thinning; frontal variant; hippocampal volumes; neuropsychiatric symptoms}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{2}},
  pages        = {{641--658}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's Disease}},
  title        = {{Neuropsychological and Neuroanatomical Features of Patients with Behavioral/Dysexecutive Variant Alzheimer's Disease (AD) : A Comparison to Behavioral Variant Frontotemporal Dementia and Amnestic AD Groups}},
  url          = {{http://dx.doi.org/10.3233/JAD-215728}},
  doi          = {{10.3233/JAD-215728}},
  volume       = {{89}},
  year         = {{2022}},
}