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Dual role of infections as risk factors for coronary heart disease.

Pesonen, Erkki LU ; Andsberg, Eva; Öhlin, Hans LU ; Puolakkainen, Mirja; Rautelin, Hilpi; Sarna, Seppo and Persson, Kenneth LU (2007) In Atherosclerosis 192(2). p.370-375
Abstract
Aims: The aim of the study was to explore whether exposure to microbial agents determines the prevalence of acute coronary events. Methods and results: Patients with unstable angina pectoris and myocardial infarction (N = 335) and their paired controls were investigated. The subjects answered a questionnaire about their childhood contagious diseases: varicella, scarlet fever, measles, rubella, mononucleosis and mumps. Blood samples were taken for bacterial and viral serology. The odds ratio for CHD was highest in the upper quartile of the enterovirus (EV), herpes simplex virus (HSV) and Chlamydia pneumoniae HSP60 IgG antibody titers (1.86, p = 0.001, 1.57, p < 0.048 and 1.70, p = 0.016, respectively). The antibody titers increased... (More)
Aims: The aim of the study was to explore whether exposure to microbial agents determines the prevalence of acute coronary events. Methods and results: Patients with unstable angina pectoris and myocardial infarction (N = 335) and their paired controls were investigated. The subjects answered a questionnaire about their childhood contagious diseases: varicella, scarlet fever, measles, rubella, mononucleosis and mumps. Blood samples were taken for bacterial and viral serology. The odds ratio for CHD was highest in the upper quartile of the enterovirus (EV), herpes simplex virus (HSV) and Chlamydia pneumoniae HSP60 IgG antibody titers (1.86, p = 0.001, 1.57, p < 0.048 and 1.70, p = 0.016, respectively). The antibody titers increased cumulatively the risk for CHD (odds ratios 1.89, 2.24, 3.92 and p-values < 0.001, 0.001 and 0.047). Childhood contagious diseases (n = 6) had a protecting effect against CHD (odds ratio 0.86, p = 0.013). The risk for acute coronary events decreased significantly with increasing number of childhood contagious diseases (p = 0.007). Conclusions: Infections have a dual role in the genesis of CHD. EV, HSV and C. pneumoniae heat shock protein 60 IgG antibodies are associated with increased risk for CHID. Protection from infections usually suffered during the childhood before the era of MMR vaccination may predispose the individual to CHD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
protein 60, Infection burden, heat shock, Chlamydia pneumoniae, enterovirus, Herpes simplex virus, hygiene hypothesis
in
Atherosclerosis
volume
192
issue
2
pages
370 - 375
publisher
Elsevier
external identifiers
  • wos:000247225900020
  • scopus:34248171688
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2006.05.018
language
English
LU publication?
yes
id
b95f5825-f996-4137-ad2f-5f474ced5020 (old id 158273)
date added to LUP
2007-07-11 13:26:21
date last changed
2017-10-08 03:24:41
@article{b95f5825-f996-4137-ad2f-5f474ced5020,
  abstract     = {Aims: The aim of the study was to explore whether exposure to microbial agents determines the prevalence of acute coronary events. Methods and results: Patients with unstable angina pectoris and myocardial infarction (N = 335) and their paired controls were investigated. The subjects answered a questionnaire about their childhood contagious diseases: varicella, scarlet fever, measles, rubella, mononucleosis and mumps. Blood samples were taken for bacterial and viral serology. The odds ratio for CHD was highest in the upper quartile of the enterovirus (EV), herpes simplex virus (HSV) and Chlamydia pneumoniae HSP60 IgG antibody titers (1.86, p = 0.001, 1.57, p &lt; 0.048 and 1.70, p = 0.016, respectively). The antibody titers increased cumulatively the risk for CHD (odds ratios 1.89, 2.24, 3.92 and p-values &lt; 0.001, 0.001 and 0.047). Childhood contagious diseases (n = 6) had a protecting effect against CHD (odds ratio 0.86, p = 0.013). The risk for acute coronary events decreased significantly with increasing number of childhood contagious diseases (p = 0.007). Conclusions: Infections have a dual role in the genesis of CHD. EV, HSV and C. pneumoniae heat shock protein 60 IgG antibodies are associated with increased risk for CHID. Protection from infections usually suffered during the childhood before the era of MMR vaccination may predispose the individual to CHD.},
  author       = {Pesonen, Erkki and Andsberg, Eva and Öhlin, Hans and Puolakkainen, Mirja and Rautelin, Hilpi and Sarna, Seppo and Persson, Kenneth},
  issn         = {1879-1484},
  keyword      = {protein 60,Infection burden,heat shock,Chlamydia pneumoniae,enterovirus,Herpes simplex virus,hygiene hypothesis},
  language     = {eng},
  number       = {2},
  pages        = {370--375},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Dual role of infections as risk factors for coronary heart disease.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2006.05.018},
  volume       = {192},
  year         = {2007},
}