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Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.

Carta, Manolo LU ; Carlsson, Thomas LU ; Munoz, Ana LU ; Kirik, Deniz LU and Björklund, Anders LU (2010) In Movement Disorders 25 Suppl 1. p.174-179
Abstract
Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also... (More)
Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Movement Disorders
volume
25 Suppl 1
pages
174 - 179
publisher
John Wiley & Sons
external identifiers
  • wos:000276137000031
  • pmid:20187238
  • scopus:77953394342
ISSN
0885-3185
DOI
10.1002/mds.22792
language
English
LU publication?
yes
id
7041d011-b7c8-4122-9f3f-331f47ed87fd (old id 1582813)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20187238?dopt=Abstract
date added to LUP
2010-04-07 09:36:56
date last changed
2018-05-29 09:56:30
@article{7041d011-b7c8-4122-9f3f-331f47ed87fd,
  abstract     = {Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory feedback control, dopamine released from serotonin terminals results in excessive swings in extracellular dopamine levels after peripheral administration of levodopa. Such "dysregulated" release of levodopa-derived dopamine is likely to be responsible for the appearance of the abnormal movements in levodopa-primed animals. This mechanism may also play a role in the development of graft-induced dyskinesias in patients that receive fetal neuron transplants, possibly due to the inclusion of serotonin neurons in the grafted ventral midbrain tissue, which contribute to maintain dopamine receptors of the denervated striatum in a supersensitive state.},
  author       = {Carta, Manolo and Carlsson, Thomas and Munoz, Ana and Kirik, Deniz and Björklund, Anders},
  issn         = {0885-3185},
  language     = {eng},
  pages        = {174--179},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.},
  url          = {http://dx.doi.org/10.1002/mds.22792},
  volume       = {25 Suppl 1},
  year         = {2010},
}