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The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation.

Larsson, David LU ; Meurling, Carl LU ; Holmqvist, Fredrik LU ; Waktare, Johan E P and Thilén, Ulf LU (2007) In International Journal of Cardiology 114(3). p.345-351
Abstract
Background: In acquired heart disease, brain natriuretic peptide (BNP) and N-Teminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult Congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We Studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a right ventricle in the systemic position or with Fontan-type physiology. Methods: A prospective longitudinal study (follow up time 23 +/- 13 months, mean +/- S.D.) was conducted in a specialised centre on 61 patients (age 26 +/- 8 years; NYHA class 1.5 +/- 0.6) including Senning/Mustard corrected transposition, congenitally corrected transposition... (More)
Background: In acquired heart disease, brain natriuretic peptide (BNP) and N-Teminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult Congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We Studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a right ventricle in the systemic position or with Fontan-type physiology. Methods: A prospective longitudinal study (follow up time 23 +/- 13 months, mean +/- S.D.) was conducted in a specialised centre on 61 patients (age 26 +/- 8 years; NYHA class 1.5 +/- 0.6) including Senning/Mustard corrected transposition, congenitally corrected transposition and Fontan/ total cavopulmonary connection. Plasma NP concentration was compared with NYHA class, exercise capacity and echocardiographically determined systemic systolic ventricular function. Results: Neurohormone concentrations were generally elevated (mean=290% of upper reference limit) and related to NYHA class (P < 0.001, NYHA I vs. II-IV). No clinically significant relationship to ventricular function or exercise capacity was found however. An NP measurement could not predict the future Course of the disease in terms of functional status or ventricular function. Conclusion: In contrast to patients with acquired heart disease, measurement of NP seems to have low clinical value in adults with a right ventricle in the systemic position or with Fontan-type physiology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
echocardiography, transposition, adult congenital heart disease, Fontan, grown-up congenital heart diseased, natriuretic peptides
in
International Journal of Cardiology
volume
114
issue
3
pages
345 - 351
publisher
Elsevier
external identifiers
  • wos:000243241500009
  • scopus:33845193371
ISSN
0167-5273
DOI
10.1016/j.ijcard.2006.01.023
language
English
LU publication?
yes
id
4dec15b2-4ce3-43be-b76a-acd0d85c9a1f (old id 158308)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16777247&dopt=Abstract
date added to LUP
2007-07-11 11:54:29
date last changed
2017-08-20 03:40:44
@article{4dec15b2-4ce3-43be-b76a-acd0d85c9a1f,
  abstract     = {Background: In acquired heart disease, brain natriuretic peptide (BNP) and N-Teminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult Congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We Studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a right ventricle in the systemic position or with Fontan-type physiology. Methods: A prospective longitudinal study (follow up time 23 +/- 13 months, mean +/- S.D.) was conducted in a specialised centre on 61 patients (age 26 +/- 8 years; NYHA class 1.5 +/- 0.6) including Senning/Mustard corrected transposition, congenitally corrected transposition and Fontan/ total cavopulmonary connection. Plasma NP concentration was compared with NYHA class, exercise capacity and echocardiographically determined systemic systolic ventricular function. Results: Neurohormone concentrations were generally elevated (mean=290% of upper reference limit) and related to NYHA class (P &lt; 0.001, NYHA I vs. II-IV). No clinically significant relationship to ventricular function or exercise capacity was found however. An NP measurement could not predict the future Course of the disease in terms of functional status or ventricular function. Conclusion: In contrast to patients with acquired heart disease, measurement of NP seems to have low clinical value in adults with a right ventricle in the systemic position or with Fontan-type physiology.},
  author       = {Larsson, David and Meurling, Carl and Holmqvist, Fredrik and Waktare, Johan E P and Thilén, Ulf},
  issn         = {0167-5273},
  keyword      = {echocardiography,transposition,adult congenital heart disease,Fontan,grown-up congenital heart diseased,natriuretic peptides},
  language     = {eng},
  number       = {3},
  pages        = {345--351},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation.},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2006.01.023},
  volume       = {114},
  year         = {2007},
}