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CART in the enteric nervous system.

Ekblad, Eva LU (2006) In Peptides 27(8). p.2024-2030
Abstract
The expression, distribution, origin, projections, chemical coding and functions of cocaine and amphetamine-regulated transcript (CART) in the gastro-intestinal tract are reviewed. CART is extensively expressed in the enteric nervous system. Except from being a possible modulator of NO induced intestinal relaxation CART does not seem to play any pivotal role in intestinal motility. Accumulating evidence suggest CART to be neuroprotective, involved in survival and maintenance of enteric neurons. CART expression increases in atrophic intestine thus suggesting a role of CART in intestinal adaptation. In rat antral mucosa CART is expressed in gastrin cells indicating a hormonal role of gastric CART.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Enteric neuronal plasticity, Intestinal adaptation, CART, Enteric nervous system, Hirschsprung's disease
in
Peptides
volume
27
issue
8
pages
2024 - 2030
publisher
Elsevier
external identifiers
  • wos:000239673100017
  • scopus:33745993356
  • pmid:16759747
ISSN
1873-5169
DOI
10.1016/j.peptides.2005.12.015
language
English
LU publication?
yes
id
90a674c5-37f7-4f83-832b-22e2a866821c (old id 158404)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16759747&dopt=Abstract
date added to LUP
2016-04-01 11:48:04
date last changed
2022-03-05 06:41:19
@article{90a674c5-37f7-4f83-832b-22e2a866821c,
  abstract     = {{The expression, distribution, origin, projections, chemical coding and functions of cocaine and amphetamine-regulated transcript (CART) in the gastro-intestinal tract are reviewed. CART is extensively expressed in the enteric nervous system. Except from being a possible modulator of NO induced intestinal relaxation CART does not seem to play any pivotal role in intestinal motility. Accumulating evidence suggest CART to be neuroprotective, involved in survival and maintenance of enteric neurons. CART expression increases in atrophic intestine thus suggesting a role of CART in intestinal adaptation. In rat antral mucosa CART is expressed in gastrin cells indicating a hormonal role of gastric CART.}},
  author       = {{Ekblad, Eva}},
  issn         = {{1873-5169}},
  keywords     = {{Enteric neuronal plasticity; Intestinal adaptation; CART; Enteric nervous system; Hirschsprung's disease}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{2024--2030}},
  publisher    = {{Elsevier}},
  series       = {{Peptides}},
  title        = {{CART in the enteric nervous system.}},
  url          = {{http://dx.doi.org/10.1016/j.peptides.2005.12.015}},
  doi          = {{10.1016/j.peptides.2005.12.015}},
  volume       = {{27}},
  year         = {{2006}},
}