Kinin receptor expression during Staphylococcus aureus infection.
Bengtson, Sara H ; Phagoo, Stephen B ; Norrby-Teglund, Anna ; Påhlman, Lisa LU ; Mörgelin, Matthias LU ; Zuraw, Bruce L ; Leeb-Lundberg, Fredrik LU and Herwald, Heiko LU
(2006)
In Blood
108(6).
p.2055-2063
- Abstract
- An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study... (More)
- An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/158556
- author
- Bengtson, Sara H
; Phagoo, Stephen B
; Norrby-Teglund, Anna
; Påhlman, Lisa
LU
; Mörgelin, Matthias
LU
; Zuraw, Bruce L
; Leeb-Lundberg, Fredrik
LU
and Herwald, Heiko
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 108
- issue
- 6
- pages
- 2055 - 2063
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000240394800048
- pmid:16735595
- scopus:33748698625
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2006-04-016444
- language
- English
- LU publication?
- yes
- id
- 65e1c9ba-5177-4f0a-8587-b3b07a29692d (old id 158556)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16735595&dopt=Abstract
- date added to LUP
- 2016-04-01 11:55:01
- date last changed
- 2022-01-26 20:10:32
@article{65e1c9ba-5177-4f0a-8587-b3b07a29692d,
abstract = {{An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections.}},
author = {{Bengtson, Sara H and Phagoo, Stephen B and Norrby-Teglund, Anna and Påhlman, Lisa and Mörgelin, Matthias and Zuraw, Bruce L and Leeb-Lundberg, Fredrik and Herwald, Heiko}},
issn = {{1528-0020}},
language = {{eng}},
number = {{6}},
pages = {{2055--2063}},
publisher = {{American Society of Hematology}},
series = {{Blood}},
title = {{Kinin receptor expression during Staphylococcus aureus infection.}},
url = {{https://lup.lub.lu.se/search/files/2701146/625507.pdf}},
doi = {{10.1182/blood-2006-04-016444}},
volume = {{108}},
year = {{2006}},
}