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Kinin receptor expression during Staphylococcus aureus infection.

Bengtson, Sara H ; Phagoo, Stephen B ; Norrby-Teglund, Anna ; Påhlman, Lisa LU ; Mörgelin, Matthias LU ; Zuraw, Bruce L ; Leeb-Lundberg, Fredrik LU and Herwald, Heiko LU orcid (2006) In Blood 108(6). p.2055-2063
Abstract
An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study... (More)
An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections. (Less)
Please use this url to cite or link to this publication:
author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
108
issue
6
pages
2055 - 2063
publisher
American Society of Hematology
external identifiers
  • wos:000240394800048
  • pmid:16735595
  • scopus:33748698625
ISSN
1528-0020
DOI
10.1182/blood-2006-04-016444
language
English
LU publication?
yes
id
65e1c9ba-5177-4f0a-8587-b3b07a29692d (old id 158556)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16735595&dopt=Abstract
date added to LUP
2016-04-01 11:55:01
date last changed
2021-08-04 01:53:28
@article{65e1c9ba-5177-4f0a-8587-b3b07a29692d,
  abstract     = {An inappropriate host response to invading bacteria is a critical parameter that often aggravates the outcome of an infection. Staphylococcus aureus is a major human Gram-positive pathogen that causes a wide array of community- and hospital-acquired diseases ranging from superficial skin infections to severe conditions such as staphylococcal toxic shock. Here we find that S aureus induces inflammatory reactions by modulating the expression and response of the B1 and B2 receptors, respectively. This process is initiated by a chain of events, involving staphylococcal-induced cytokine release from monocytes, bacteria-triggered contact activation, and conversion of bradykinin to its metabolite desArg9bradykinin. The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections.},
  author       = {Bengtson, Sara H and Phagoo, Stephen B and Norrby-Teglund, Anna and Påhlman, Lisa and Mörgelin, Matthias and Zuraw, Bruce L and Leeb-Lundberg, Fredrik and Herwald, Heiko},
  issn         = {1528-0020},
  language     = {eng},
  number       = {6},
  pages        = {2055--2063},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Kinin receptor expression during Staphylococcus aureus infection.},
  url          = {https://lup.lub.lu.se/search/files/2701146/625507.pdf},
  doi          = {10.1182/blood-2006-04-016444},
  volume       = {108},
  year         = {2006},
}