Stent Thrombosis in Sweden A Report From the Swedish Coronary Angiography and Angioplasty Registry
(2009) In Circulation. Cardiovascular Interventions 2(5). p.401-408- Abstract
- Background-The objective was to evaluate the role of risk factors and stent type for stent thrombosis (ST) using a large real world registry. Methods and Results-We evaluated all consecutive coronary stent implantations in Sweden from May 1, 2005, to June 30, 2007. All cases of ST, documented in the Swedish coronary angiography and angioplasty registry until September 21, 2008, were analyzed. ST was registered in 882 of 73 798 stents. Acute coronary syndromes, insulin-treated diabetes mellitus, smoking, previous coronary intervention, warfarin treatment, small stent diameter, and stenting in restenotic, complex, or bypass graft lesions had the strongest association with ST in the multivariable statistical model. There were considerable... (More)
- Background-The objective was to evaluate the role of risk factors and stent type for stent thrombosis (ST) using a large real world registry. Methods and Results-We evaluated all consecutive coronary stent implantations in Sweden from May 1, 2005, to June 30, 2007. All cases of ST, documented in the Swedish coronary angiography and angioplasty registry until September 21, 2008, were analyzed. ST was registered in 882 of 73 798 stents. Acute coronary syndromes, insulin-treated diabetes mellitus, smoking, previous coronary intervention, warfarin treatment, small stent diameter, and stenting in restenotic, complex, or bypass graft lesions had the strongest association with ST in the multivariable statistical model. There were considerable differences in the frequency of ST between different stent brands. The overall risk of ST was lower in drug-eluting stents compared with bare metal stents (adjusted risk ratio, 0.79; 99% CI, 0.63 to 0.99). However, from 6 months after stent implantation and onward, the risk for ST was higher in drug-eluting stents compared with bare metal stents (adjusted risk ratio, 2.02; 99% CI, 1.30 to 3.14). Conclusions-ST is a multifactor disease, and the incidence varies considerably between patients based on clinical, vessel, and stent characteristics. For drug-eluting stents compared with bare metal stents, the risk pattern was biphasic; initially, bare metal stents demonstrated a higher risk of ST; whereas after the first months, ST risk was higher with drug-eluting stents. Our findings highlight the need for prospective randomized studies with head-to-head comparisons between different stents. (Circ Cardiovasc Intervent. 2009;2:401-408.) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1586362
- author
- Lagerqvist, Bo ; Carlsson, Jorg ; Frobert, Ole ; Lindback, Johan ; Scherstén, Fredrik LU ; Stenestrand, Ulf and James, Stefan K.
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- revascularization, angioplasty, myocardial infarction, stent, thrombosis
- in
- Circulation. Cardiovascular Interventions
- volume
- 2
- issue
- 5
- pages
- 401 - 408
- publisher
- American Heart Association
- external identifiers
-
- wos:000276068800006
- scopus:73949085452
- pmid:20031749
- ISSN
- 1941-7632
- DOI
- 10.1161/CIRCINTERVENTIONS.108.844985
- language
- English
- LU publication?
- yes
- id
- 1d8bc012-98d2-4de7-8336-847fc5f139a6 (old id 1586362)
- date added to LUP
- 2016-04-01 12:23:46
- date last changed
- 2022-04-21 06:54:14
@article{1d8bc012-98d2-4de7-8336-847fc5f139a6,
abstract = {{Background-The objective was to evaluate the role of risk factors and stent type for stent thrombosis (ST) using a large real world registry. Methods and Results-We evaluated all consecutive coronary stent implantations in Sweden from May 1, 2005, to June 30, 2007. All cases of ST, documented in the Swedish coronary angiography and angioplasty registry until September 21, 2008, were analyzed. ST was registered in 882 of 73 798 stents. Acute coronary syndromes, insulin-treated diabetes mellitus, smoking, previous coronary intervention, warfarin treatment, small stent diameter, and stenting in restenotic, complex, or bypass graft lesions had the strongest association with ST in the multivariable statistical model. There were considerable differences in the frequency of ST between different stent brands. The overall risk of ST was lower in drug-eluting stents compared with bare metal stents (adjusted risk ratio, 0.79; 99% CI, 0.63 to 0.99). However, from 6 months after stent implantation and onward, the risk for ST was higher in drug-eluting stents compared with bare metal stents (adjusted risk ratio, 2.02; 99% CI, 1.30 to 3.14). Conclusions-ST is a multifactor disease, and the incidence varies considerably between patients based on clinical, vessel, and stent characteristics. For drug-eluting stents compared with bare metal stents, the risk pattern was biphasic; initially, bare metal stents demonstrated a higher risk of ST; whereas after the first months, ST risk was higher with drug-eluting stents. Our findings highlight the need for prospective randomized studies with head-to-head comparisons between different stents. (Circ Cardiovasc Intervent. 2009;2:401-408.)}},
author = {{Lagerqvist, Bo and Carlsson, Jorg and Frobert, Ole and Lindback, Johan and Scherstén, Fredrik and Stenestrand, Ulf and James, Stefan K.}},
issn = {{1941-7632}},
keywords = {{revascularization; angioplasty; myocardial infarction; stent; thrombosis}},
language = {{eng}},
number = {{5}},
pages = {{401--408}},
publisher = {{American Heart Association}},
series = {{Circulation. Cardiovascular Interventions}},
title = {{Stent Thrombosis in Sweden A Report From the Swedish Coronary Angiography and Angioplasty Registry}},
url = {{http://dx.doi.org/10.1161/CIRCINTERVENTIONS.108.844985}},
doi = {{10.1161/CIRCINTERVENTIONS.108.844985}},
volume = {{2}},
year = {{2009}},
}