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Continuous flow hollow fiber liquid-phase microextraction and monitoring of NSAID pharmaceuticals in a sewage treatment plant effluent

Larsson, Niklas LU ; Larsson, Estelle LU ; Rylander, Marika and Jönsson, Jan Åke LU (2009) In Analytical Methods 1(1). p.59-67
Abstract
A method for simultaneous extraction and quantification Of four non-steroidal anti-inflammatory drugs (NSAIDs) based on continuous flow hollow fiber liquid-phase microextraction (CFHF-LPME) was developed. The effect of sample flow rate, acceptor flow rate, type of acceptor flow (continuous, semi-continuous or forward-backward), type of supported liquid membrane and sample volume was studied. The extraction of the final method was linear over an environmentally relevant concentration range and yielded high enrichment factors (720-940 times) in reagent water and (270-800 times) in sewage water for all analytes within 45 min. Repeatability was best (RSD 6-15%) during the first 30 min of extraction. The optimised method was used to monitor the... (More)
A method for simultaneous extraction and quantification Of four non-steroidal anti-inflammatory drugs (NSAIDs) based on continuous flow hollow fiber liquid-phase microextraction (CFHF-LPME) was developed. The effect of sample flow rate, acceptor flow rate, type of acceptor flow (continuous, semi-continuous or forward-backward), type of supported liquid membrane and sample volume was studied. The extraction of the final method was linear over an environmentally relevant concentration range and yielded high enrichment factors (720-940 times) in reagent water and (270-800 times) in sewage water for all analytes within 45 min. Repeatability was best (RSD 6-15%) during the first 30 min of extraction. The optimised method was used to monitor the occurrence and fate of the four NSAIDs in a Swedish sewage treatment plant (STP) effluent, which is discharged into a system of ponds before release into a river, during the period May-September 2008. All four analytes were detected at concentrations up to 0.92 mu g L-1 ketoprofen, 0.08 mu g L-1 naproxen, 0.43 mu g L-1 diclofenac and 0.25 mu g L-1 ibuprofen. A concentration drop during the summer was observed. For diclofenac and ketoprofen significant removal in the primary recipient pond system was observed. The presence of the studied pharmaceuticals in STP effluent together with concern about their environmental effects makes monitoring of their occurrence and knowledge of their environmental fate important. The proposed method provides a basis for automation of extraction towards on-site extraction using CFHF-LPME. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Methods
volume
1
issue
1
pages
59 - 67
publisher
Royal Society of Chemistry
external identifiers
  • wos:000275134600008
  • scopus:77953675371
ISSN
1759-9660
DOI
10.1039/b9ay00015a
language
English
LU publication?
yes
id
afc95366-e0cd-42cc-bab4-5a70e0d78f15 (old id 1586424)
date added to LUP
2010-04-28 08:30:10
date last changed
2017-08-06 03:39:59
@article{afc95366-e0cd-42cc-bab4-5a70e0d78f15,
  abstract     = {A method for simultaneous extraction and quantification Of four non-steroidal anti-inflammatory drugs (NSAIDs) based on continuous flow hollow fiber liquid-phase microextraction (CFHF-LPME) was developed. The effect of sample flow rate, acceptor flow rate, type of acceptor flow (continuous, semi-continuous or forward-backward), type of supported liquid membrane and sample volume was studied. The extraction of the final method was linear over an environmentally relevant concentration range and yielded high enrichment factors (720-940 times) in reagent water and (270-800 times) in sewage water for all analytes within 45 min. Repeatability was best (RSD 6-15%) during the first 30 min of extraction. The optimised method was used to monitor the occurrence and fate of the four NSAIDs in a Swedish sewage treatment plant (STP) effluent, which is discharged into a system of ponds before release into a river, during the period May-September 2008. All four analytes were detected at concentrations up to 0.92 mu g L-1 ketoprofen, 0.08 mu g L-1 naproxen, 0.43 mu g L-1 diclofenac and 0.25 mu g L-1 ibuprofen. A concentration drop during the summer was observed. For diclofenac and ketoprofen significant removal in the primary recipient pond system was observed. The presence of the studied pharmaceuticals in STP effluent together with concern about their environmental effects makes monitoring of their occurrence and knowledge of their environmental fate important. The proposed method provides a basis for automation of extraction towards on-site extraction using CFHF-LPME.},
  author       = {Larsson, Niklas and Larsson, Estelle and Rylander, Marika and Jönsson, Jan Åke},
  issn         = {1759-9660},
  language     = {eng},
  number       = {1},
  pages        = {59--67},
  publisher    = {Royal Society of Chemistry},
  series       = {Analytical Methods},
  title        = {Continuous flow hollow fiber liquid-phase microextraction and monitoring of NSAID pharmaceuticals in a sewage treatment plant effluent},
  url          = {http://dx.doi.org/10.1039/b9ay00015a},
  volume       = {1},
  year         = {2009},
}