Structure–activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins
(2005) In Organic and Biomolecular Chemistry 3(5). p.886-900- Abstract
- Four collections of Gal1-4Gal derivatives were synthesised and evaluated as inhibitors of the PapG class II adhesin of uropathogenic Escherichia coli and of the PN and PO adhesins of Streptococcus suis strains. Galabiosides carrying aromatic structures at C1, methoxyphenyl O-galabiosides in particular, were identified as potent inhibitors of the PapG adhesin. Phenylurea derivatisation at C3 and methoxymethylation at O2 of galabiose provided inhibitors of the S. suis strains type PN adhesin with remarkably high affinities (30 and 50 nM, respectively). In addition, quantitative structure–activity relationship models for E. coli PapG adhesin and S. suis adhesin type PO were developed using multivariate data analysis. The inhibitory lead... (More)
- Four collections of Gal1-4Gal derivatives were synthesised and evaluated as inhibitors of the PapG class II adhesin of uropathogenic Escherichia coli and of the PN and PO adhesins of Streptococcus suis strains. Galabiosides carrying aromatic structures at C1, methoxyphenyl O-galabiosides in particular, were identified as potent inhibitors of the PapG adhesin. Phenylurea derivatisation at C3 and methoxymethylation at O2 of galabiose provided inhibitors of the S. suis strains type PN adhesin with remarkably high affinities (30 and 50 nM, respectively). In addition, quantitative structure–activity relationship models for E. coli PapG adhesin and S. suis adhesin type PO were developed using multivariate data analysis. The inhibitory lead structures constitute an advancement towards high-affinity inhibitors as potential anti-adhesion therapeutic agents targeting bacterial infections. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/158699
- author
- Ohlsson, Jörgen LU ; Larsson, A ; Haataja, S ; Alajääski, J ; Stenlund, P ; Pinkner, J ; Hultgren, S ; Finne, J ; Kihlberg, J and Nilsson, Ulf LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Organic and Biomolecular Chemistry
- volume
- 3
- issue
- 5
- pages
- 886 - 900
- publisher
- Royal Society of Chemistry
- external identifiers
-
- wos:000227218500025
- pmid:15731876
- scopus:20144369748
- ISSN
- 1477-0539
- DOI
- 10.1039/b416878j
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 929a9971-9602-4d56-b845-75d079103e26 (old id 158699)
- date added to LUP
- 2016-04-01 11:50:11
- date last changed
- 2022-01-26 18:57:58
@article{929a9971-9602-4d56-b845-75d079103e26, abstract = {{Four collections of Gal1-4Gal derivatives were synthesised and evaluated as inhibitors of the PapG class II adhesin of uropathogenic Escherichia coli and of the PN and PO adhesins of Streptococcus suis strains. Galabiosides carrying aromatic structures at C1, methoxyphenyl O-galabiosides in particular, were identified as potent inhibitors of the PapG adhesin. Phenylurea derivatisation at C3 and methoxymethylation at O2 of galabiose provided inhibitors of the S. suis strains type PN adhesin with remarkably high affinities (30 and 50 nM, respectively). In addition, quantitative structure–activity relationship models for E. coli PapG adhesin and S. suis adhesin type PO were developed using multivariate data analysis. The inhibitory lead structures constitute an advancement towards high-affinity inhibitors as potential anti-adhesion therapeutic agents targeting bacterial infections.}}, author = {{Ohlsson, Jörgen and Larsson, A and Haataja, S and Alajääski, J and Stenlund, P and Pinkner, J and Hultgren, S and Finne, J and Kihlberg, J and Nilsson, Ulf}}, issn = {{1477-0539}}, language = {{eng}}, number = {{5}}, pages = {{886--900}}, publisher = {{Royal Society of Chemistry}}, series = {{Organic and Biomolecular Chemistry}}, title = {{Structure–activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins}}, url = {{http://dx.doi.org/10.1039/b416878j}}, doi = {{10.1039/b416878j}}, volume = {{3}}, year = {{2005}}, }