Advanced

Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections

Nowroozalizadeh, Salma; Månsson, Fredrik LU ; da Silva, Zacarias; Repits, Johanna LU ; Dabo, Braima; Pereira, Carla; Biague, Antonio; Albert, Jan; Nielsen, Jens and Aaby, Peter, et al. (2010) 5th Smögen Symposium on Virology In Journal of Infectious Diseases 201(8). p.1150-1154
Abstract
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both... (More)
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
201
issue
8
pages
1150 - 1154
publisher
Oxford University Press
conference name
5th Smögen Symposium on Virology
external identifiers
  • wos:000275493400007
  • scopus:77950267769
ISSN
1537-6613
language
English
LU publication?
yes
id
a40f3715-426d-4906-b83f-5088c58c50e3 (old id 1588349)
alternative location
https://www.jstor.org/stable/pdf/40599263.pdf
date added to LUP
2010-04-22 09:42:44
date last changed
2018-05-29 11:49:50
@article{a40f3715-426d-4906-b83f-5088c58c50e3,
  abstract     = {Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.},
  author       = {Nowroozalizadeh, Salma and Månsson, Fredrik and da Silva, Zacarias and Repits, Johanna and Dabo, Braima and Pereira, Carla and Biague, Antonio and Albert, Jan and Nielsen, Jens and Aaby, Peter and Fenyö, Eva Maria and Norrgren, Hans and Holmgren, Birgitta G and Jansson, Marianne},
  issn         = {1537-6613},
  language     = {eng},
  number       = {8},
  pages        = {1150--1154},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections},
  volume       = {201},
  year         = {2010},
}