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Bone substitute as an on-lay graft on rat tibia

Truedsson, A.; Wang, Jian-Sheng LU ; Lindberg, P.; Gordh, M.; Sunzel, B. and Warfvinge, G. (2010) In Clinical Oral Implants Research 21(4). p.424-429
Abstract
Objectives To investigate the capacity of Cerament (R), an injectable bone substitute, to guide bone generation from a cortical surface. Materials and method Cerament (R) was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats. Results In both groups, the thickness of the bone cortex increased significantly from 473 +/- 58 mu m (mean +/- SD) at day 0 to 1193 +/- 255 mu m (Cerament (R)) and 942 +/- 323 mu m (sham) after 3 weeks. In the Cerament (R) group, the new bone thickness remained constant (1258 +/- 288 mu m) until the end of the experiment at 12 weeks, while the sham group demonstrated a return to initial cortical... (More)
Objectives To investigate the capacity of Cerament (R), an injectable bone substitute, to guide bone generation from a cortical surface. Materials and method Cerament (R) was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats. Results In both groups, the thickness of the bone cortex increased significantly from 473 +/- 58 mu m (mean +/- SD) at day 0 to 1193 +/- 255 mu m (Cerament (R)) and 942 +/- 323 mu m (sham) after 3 weeks. In the Cerament (R) group, the new bone thickness remained constant (1258 +/- 288 mu m) until the end of the experiment at 12 weeks, while the sham group demonstrated a return to initial cortical thickness (591 +/- 73 mu m) at 12 weeks. The newly formed bone in the Cerament (R) group was highly trabecular after 3 weeks but attained a normal trabecular structure of the cortex after 12 weeks. Conclusion Cerament (R) may guide bone generation from an intact cortical bone surface. Although bone remodeling speed may differ between rats and humans, our study indicates that Cerament (R) may become a useful alternative to autologous bone, both to fill defects and to increase bone volume by cortical augmentation. To cite this article:Truedsson A, Wang J-S, Lindberg P, Gordh M, Sunzel B, Warfvinge G. Bone substitute as an on-lay graft on rat tibia. Clin. Oral Impl. Res. 21, 2010; 424-429.doi: 10.1111/j.1600-0501.2009.01875.x. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
histopathology, animal experiments, bone substitutes, host mechanisms
in
Clinical Oral Implants Research
volume
21
issue
4
pages
424 - 429
publisher
Wiley-Blackwell
external identifiers
  • wos:000275443500010
  • scopus:77951596837
ISSN
1600-0501
DOI
10.1111/j.1600-0501.2009.01875.x
language
English
LU publication?
yes
id
b59505c7-fe85-4383-94a2-d9e84674af87 (old id 1589119)
date added to LUP
2010-04-20 13:51:52
date last changed
2018-05-29 12:05:57
@article{b59505c7-fe85-4383-94a2-d9e84674af87,
  abstract     = {Objectives To investigate the capacity of Cerament (R), an injectable bone substitute, to guide bone generation from a cortical surface. Materials and method Cerament (R) was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats. Results In both groups, the thickness of the bone cortex increased significantly from 473 +/- 58 mu m (mean +/- SD) at day 0 to 1193 +/- 255 mu m (Cerament (R)) and 942 +/- 323 mu m (sham) after 3 weeks. In the Cerament (R) group, the new bone thickness remained constant (1258 +/- 288 mu m) until the end of the experiment at 12 weeks, while the sham group demonstrated a return to initial cortical thickness (591 +/- 73 mu m) at 12 weeks. The newly formed bone in the Cerament (R) group was highly trabecular after 3 weeks but attained a normal trabecular structure of the cortex after 12 weeks. Conclusion Cerament (R) may guide bone generation from an intact cortical bone surface. Although bone remodeling speed may differ between rats and humans, our study indicates that Cerament (R) may become a useful alternative to autologous bone, both to fill defects and to increase bone volume by cortical augmentation. To cite this article:Truedsson A, Wang J-S, Lindberg P, Gordh M, Sunzel B, Warfvinge G. Bone substitute as an on-lay graft on rat tibia. Clin. Oral Impl. Res. 21, 2010; 424-429.doi: 10.1111/j.1600-0501.2009.01875.x.},
  author       = {Truedsson, A. and Wang, Jian-Sheng and Lindberg, P. and Gordh, M. and Sunzel, B. and Warfvinge, G.},
  issn         = {1600-0501},
  keyword      = {histopathology,animal experiments,bone substitutes,host mechanisms},
  language     = {eng},
  number       = {4},
  pages        = {424--429},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Oral Implants Research},
  title        = {Bone substitute as an on-lay graft on rat tibia},
  url          = {http://dx.doi.org/10.1111/j.1600-0501.2009.01875.x},
  volume       = {21},
  year         = {2010},
}