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Drug release from lipid liquid crystalline phases: relation with phase behavior

Costa, Fatima LU ; Sparr, Emma LU ; Simoes Sousa, Joao Jose and Pais, Alberto Canelas (2010) In Drug Development and Industrial Pharmacy 36(4). p.470-481
Abstract
Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for... (More)
Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.</. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hydrochloride, propranolol, phytantriol, monoolein, drug release, Cubic phase, diolein
in
Drug Development and Industrial Pharmacy
volume
36
issue
4
pages
470 - 481
publisher
Marcel Dekker
external identifiers
  • wos:000275224700013
  • scopus:77749304432
ISSN
0363-9045
DOI
10.3109/03639040903261997
language
English
LU publication?
yes
id
169bd720-8645-481f-820e-49f597b04dee (old id 1589642)
date added to LUP
2010-04-20 09:35:32
date last changed
2018-06-03 03:13:51
@article{169bd720-8645-481f-820e-49f597b04dee,
  abstract     = {Introduction: We studied the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug, from monoolein (MO)/water and phytantriol/water systems. Methods: We related the dissolution profiles with phase behavior and viscosity of the different liquid crystalline phases. Diolein has been added aiming to stabilize the cubic phases and thus preventing formation of less viscous (lamellar) phases. Results: Formulations display first-order release rates and diffusion release mechanism. Some formulations (mostly MO) were close to zero-order release in the first 120 minutes. Discussion: Release mechanism can be influenced by phase changes during dissolution. Conclusions: Both MO and phytantriol show good potential to be used for propranolol hydrochloride sustained drug release.&lt;/.},
  author       = {Costa, Fatima and Sparr, Emma and Simoes Sousa, Joao Jose and Pais, Alberto Canelas},
  issn         = {0363-9045},
  keyword      = {hydrochloride,propranolol,phytantriol,monoolein,drug release,Cubic phase,diolein},
  language     = {eng},
  number       = {4},
  pages        = {470--481},
  publisher    = {Marcel Dekker},
  series       = {Drug Development and Industrial Pharmacy},
  title        = {Drug release from lipid liquid crystalline phases: relation with phase behavior},
  url          = {http://dx.doi.org/10.3109/03639040903261997},
  volume       = {36},
  year         = {2010},
}