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Umbilical cord plasma levels of growth-arrest specific protein 6 in intrauterine growth restriction

Lindqvist, Pelle G.; Balogh, Istvan LU and Dahlbäck, Björn LU (2010) In Acta Obstetricia et Gynecologica Scandinavica 89(1). p.22-26
Abstract
Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen samples from cases and controls in a prospective cohort study. Methods. GAS6 was measured with an enzyme-linked immunosorbent assay method in umbilical cord plasma taken immediately after delivery. Main outcome measure. Differences in GAS6 levels between pregnancies with placental insufficiency and those without. Results. GAS6 levels were... (More)
Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen samples from cases and controls in a prospective cohort study. Methods. GAS6 was measured with an enzyme-linked immunosorbent assay method in umbilical cord plasma taken immediately after delivery. Main outcome measure. Differences in GAS6 levels between pregnancies with placental insufficiency and those without. Results. GAS6 levels were significantly higher among newborns with abnormal umbilical cord Doppler tracings (19.5 +/- 5.3 vs. 15.0 +/- 3.2, p = 0.02). Among those with abnormal umbilical cord tracings (n = 9), the two with umbilical venous pulsations had significantly lower GAS6 levels (mean 14.4 vs. 21.1, p = 0.04) and one of them died after delivery. Conclusions. GAS6 levels are raised in IUGR fetuses and we speculate that GAS6 might be involved in the fetal adaptation to placental insufficiency. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
growth arrest specific, Placental insufficiency, growth restriction, protein 6, abnormal umbilical artery Doppler
in
Acta Obstetricia et Gynecologica Scandinavica
volume
89
issue
1
pages
22 - 26
publisher
Wiley-Blackwell
external identifiers
  • wos:000275251200005
  • scopus:74049114472
ISSN
1600-0412
DOI
10.3109/00016340903410899
language
English
LU publication?
yes
id
93f2cb2e-0ea6-41e5-9bc1-29b591d12874 (old id 1589837)
date added to LUP
2010-04-19 14:33:57
date last changed
2018-05-29 10:58:41
@article{93f2cb2e-0ea6-41e5-9bc1-29b591d12874,
  abstract     = {Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen samples from cases and controls in a prospective cohort study. Methods. GAS6 was measured with an enzyme-linked immunosorbent assay method in umbilical cord plasma taken immediately after delivery. Main outcome measure. Differences in GAS6 levels between pregnancies with placental insufficiency and those without. Results. GAS6 levels were significantly higher among newborns with abnormal umbilical cord Doppler tracings (19.5 +/- 5.3 vs. 15.0 +/- 3.2, p = 0.02). Among those with abnormal umbilical cord tracings (n = 9), the two with umbilical venous pulsations had significantly lower GAS6 levels (mean 14.4 vs. 21.1, p = 0.04) and one of them died after delivery. Conclusions. GAS6 levels are raised in IUGR fetuses and we speculate that GAS6 might be involved in the fetal adaptation to placental insufficiency.},
  author       = {Lindqvist, Pelle G. and Balogh, Istvan and Dahlbäck, Björn},
  issn         = {1600-0412},
  keyword      = {growth arrest specific,Placental insufficiency,growth restriction,protein 6,abnormal umbilical artery Doppler},
  language     = {eng},
  number       = {1},
  pages        = {22--26},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Obstetricia et Gynecologica Scandinavica},
  title        = {Umbilical cord plasma levels of growth-arrest specific protein 6 in intrauterine growth restriction},
  url          = {http://dx.doi.org/10.3109/00016340903410899},
  volume       = {89},
  year         = {2010},
}