Umbilical cord plasma levels of growth-arrest specific protein 6 in intrauterine growth restriction
(2010) In Acta Obstetricia et Gynecologica Scandinavica 89(1). p.22-26- Abstract
- Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen samples from cases and controls in a prospective cohort study. Methods. GAS6 was measured with an enzyme-linked immunosorbent assay method in umbilical cord plasma taken immediately after delivery. Main outcome measure. Differences in GAS6 levels between pregnancies with placental insufficiency and those without. Results. GAS6 levels were... (More)
- Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen samples from cases and controls in a prospective cohort study. Methods. GAS6 was measured with an enzyme-linked immunosorbent assay method in umbilical cord plasma taken immediately after delivery. Main outcome measure. Differences in GAS6 levels between pregnancies with placental insufficiency and those without. Results. GAS6 levels were significantly higher among newborns with abnormal umbilical cord Doppler tracings (19.5 +/- 5.3 vs. 15.0 +/- 3.2, p = 0.02). Among those with abnormal umbilical cord tracings (n = 9), the two with umbilical venous pulsations had significantly lower GAS6 levels (mean 14.4 vs. 21.1, p = 0.04) and one of them died after delivery. Conclusions. GAS6 levels are raised in IUGR fetuses and we speculate that GAS6 might be involved in the fetal adaptation to placental insufficiency. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1589837
- author
- Lindqvist, Pelle G. ; Balogh, Istvan LU and Dahlbäck, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- growth arrest specific, Placental insufficiency, growth restriction, protein 6, abnormal umbilical artery Doppler
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 89
- issue
- 1
- pages
- 22 - 26
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000275251200005
- scopus:74049114472
- pmid:19916876
- ISSN
- 1600-0412
- DOI
- 10.3109/00016340903410899
- language
- English
- LU publication?
- yes
- id
- 93f2cb2e-0ea6-41e5-9bc1-29b591d12874 (old id 1589837)
- date added to LUP
- 2016-04-01 13:09:02
- date last changed
- 2022-01-27 17:34:22
@article{93f2cb2e-0ea6-41e5-9bc1-29b591d12874, abstract = {{Objective. Growth arrest specific protein 6 (GAS6) is a newly discovered antiapoptotic protein related to cell survival. We hypothesized that GAS6 might be involved in the fetal adaptation to intrauterine growth restriction (IUGR). Design. A nested case-control study. Setting. A retrospective study of 25 small-for-gestational age and 36 appropriate-for-gestational age pregnancies. Sample. Frozen samples from cases and controls in a prospective cohort study. Methods. GAS6 was measured with an enzyme-linked immunosorbent assay method in umbilical cord plasma taken immediately after delivery. Main outcome measure. Differences in GAS6 levels between pregnancies with placental insufficiency and those without. Results. GAS6 levels were significantly higher among newborns with abnormal umbilical cord Doppler tracings (19.5 +/- 5.3 vs. 15.0 +/- 3.2, p = 0.02). Among those with abnormal umbilical cord tracings (n = 9), the two with umbilical venous pulsations had significantly lower GAS6 levels (mean 14.4 vs. 21.1, p = 0.04) and one of them died after delivery. Conclusions. GAS6 levels are raised in IUGR fetuses and we speculate that GAS6 might be involved in the fetal adaptation to placental insufficiency.}}, author = {{Lindqvist, Pelle G. and Balogh, Istvan and Dahlbäck, Björn}}, issn = {{1600-0412}}, keywords = {{growth arrest specific; Placental insufficiency; growth restriction; protein 6; abnormal umbilical artery Doppler}}, language = {{eng}}, number = {{1}}, pages = {{22--26}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Obstetricia et Gynecologica Scandinavica}}, title = {{Umbilical cord plasma levels of growth-arrest specific protein 6 in intrauterine growth restriction}}, url = {{http://dx.doi.org/10.3109/00016340903410899}}, doi = {{10.3109/00016340903410899}}, volume = {{89}}, year = {{2010}}, }