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ACTH reduces the rise in ApoB-48 levels after fat intake.

Skoog, Maria LU ; Xu, Ning LU ; Berggren Söderlund, Maria LU ; Lovegrove, Julie A and Nilsson-Ehle, Peter LU (2007) In Atherosclerosis 191(2). p.433-439
Abstract
It has been repeatedly demonstrated that ACTH administration lowers plasma lipid concentrations in man. The present study was designed to test the hypothesis, based on observations of decreased apolipoprotein B (ApoB) synthesis and secretion in vitro, that ACTH administration inhibits the postprandial output of ApoB in man. Therefore, we studied the response to a fat-rich meal supplemented with Vitamin A in eight healthy volunteers, who underwent this test without premedication, after 4 days administration of ACTH, and after 4 days administration of a glucocorticoid (betamethasone).



As expected, fasting plasma levels of low-density lipoproteins (LDL)-cholesterol (−25%) and ApoB (−17%) decreased after ACTH, but not after... (More)
It has been repeatedly demonstrated that ACTH administration lowers plasma lipid concentrations in man. The present study was designed to test the hypothesis, based on observations of decreased apolipoprotein B (ApoB) synthesis and secretion in vitro, that ACTH administration inhibits the postprandial output of ApoB in man. Therefore, we studied the response to a fat-rich meal supplemented with Vitamin A in eight healthy volunteers, who underwent this test without premedication, after 4 days administration of ACTH, and after 4 days administration of a glucocorticoid (betamethasone).



As expected, fasting plasma levels of low-density lipoproteins (LDL)-cholesterol (−25%) and ApoB (−17%) decreased after ACTH, but not after betamethasone administration. Also, the elevation of plasma ApoB-48 in response to fat intake (to twice the basal levels) was markedly reduced after ACTH administration. However, the postprandial rise in plasma triglycerides and retinyl palmitate was unimpaired, suggesting that ACTH administration induced the secretion of fewer but larger chylomicrons. The effect of betamethasone on the postprandial response was similar but less pronounced.



This study confirms earlier reports on the lipid-lowering effects of ACTH and supports our theory, based on in vitro studies, that the lipid-lowering effects of ACTH administration in man involves an inhibition of ApoB production. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ApoB, Lipoprotein metabolism, Postprandial, ACTH
in
Atherosclerosis
volume
191
issue
2
pages
433 - 439
publisher
Elsevier
external identifiers
  • wos:000245730100029
  • scopus:33947160150
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2006.05.012
language
English
LU publication?
yes
id
d383eb27-7e88-4243-8a1f-a63589ef94ec (old id 158989)
date added to LUP
2007-07-06 08:07:38
date last changed
2017-01-01 05:11:14
@article{d383eb27-7e88-4243-8a1f-a63589ef94ec,
  abstract     = {It has been repeatedly demonstrated that ACTH administration lowers plasma lipid concentrations in man. The present study was designed to test the hypothesis, based on observations of decreased apolipoprotein B (ApoB) synthesis and secretion in vitro, that ACTH administration inhibits the postprandial output of ApoB in man. Therefore, we studied the response to a fat-rich meal supplemented with Vitamin A in eight healthy volunteers, who underwent this test without premedication, after 4 days administration of ACTH, and after 4 days administration of a glucocorticoid (betamethasone).<br/><br>
<br/><br>
As expected, fasting plasma levels of low-density lipoproteins (LDL)-cholesterol (−25%) and ApoB (−17%) decreased after ACTH, but not after betamethasone administration. Also, the elevation of plasma ApoB-48 in response to fat intake (to twice the basal levels) was markedly reduced after ACTH administration. However, the postprandial rise in plasma triglycerides and retinyl palmitate was unimpaired, suggesting that ACTH administration induced the secretion of fewer but larger chylomicrons. The effect of betamethasone on the postprandial response was similar but less pronounced.<br/><br>
<br/><br>
This study confirms earlier reports on the lipid-lowering effects of ACTH and supports our theory, based on in vitro studies, that the lipid-lowering effects of ACTH administration in man involves an inhibition of ApoB production.},
  author       = {Skoog, Maria and Xu, Ning and Berggren Söderlund, Maria and Lovegrove, Julie A and Nilsson-Ehle, Peter},
  issn         = {1879-1484},
  keyword      = {ApoB,Lipoprotein metabolism,Postprandial,ACTH},
  language     = {eng},
  number       = {2},
  pages        = {433--439},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {ACTH reduces the rise in ApoB-48 levels after fat intake.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2006.05.012},
  volume       = {191},
  year         = {2007},
}