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New drugs in migraine treatment and prophylaxis: telcagepant and topiramate.

Edvinsson, Lars LU and Linde, Mattias (2010) In The Lancet May 4. p.645-655
Abstract
Although the triptan drugs provide effective relief from migraine for many patients, a substantial number of affected individuals are unresponsive to these compounds, and such therapy can also lead to a range of adverse effects. Telcagepant represents a new class of antimigraine drug-the calcitonin gene-related peptide receptor blockers. This compound exerts its effects by blocking receptors for the calcitonin-gene-related peptide at several sites in the trigeminal and central nervous systems, resulting in pain relief. Telcagepant does not cause vasoconstriction, a major limitation in the use of triptans. Comparisons with triptans in clinical trials for acute treatment of migraine attacks revealed clinical effects similar to those of... (More)
Although the triptan drugs provide effective relief from migraine for many patients, a substantial number of affected individuals are unresponsive to these compounds, and such therapy can also lead to a range of adverse effects. Telcagepant represents a new class of antimigraine drug-the calcitonin gene-related peptide receptor blockers. This compound exerts its effects by blocking receptors for the calcitonin-gene-related peptide at several sites in the trigeminal and central nervous systems, resulting in pain relief. Telcagepant does not cause vasoconstriction, a major limitation in the use of triptans. Comparisons with triptans in clinical trials for acute treatment of migraine attacks revealed clinical effects similar to those of triptans but better than those of placebo. Telcagepant might provide hope for those who have a poor response to, or are unable to use, older drugs. In patients who need prophylaxis because of frequent attacks of migraine, topiramate is a first-line drug for migraine prevention in many countries; it is generally safe and reasonably well tolerated. Data suggest that topiramate could aid reversion of chronic migraine to episodic migraine. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
May 4
pages
645 - 655
publisher
Elsevier Limited
external identifiers
  • wos:000281309100035
  • pmid:20416945
  • scopus:77956074035
ISSN
1474-547X
DOI
10.1016/S0140-6736(10)60323-6
language
English
LU publication?
yes
id
2ee56464-3156-4c72-8f91-14e18ab9afb5 (old id 1594845)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20416945?dopt=Abstract
date added to LUP
2010-05-04 23:16:39
date last changed
2018-07-01 04:24:27
@article{2ee56464-3156-4c72-8f91-14e18ab9afb5,
  abstract     = {Although the triptan drugs provide effective relief from migraine for many patients, a substantial number of affected individuals are unresponsive to these compounds, and such therapy can also lead to a range of adverse effects. Telcagepant represents a new class of antimigraine drug-the calcitonin gene-related peptide receptor blockers. This compound exerts its effects by blocking receptors for the calcitonin-gene-related peptide at several sites in the trigeminal and central nervous systems, resulting in pain relief. Telcagepant does not cause vasoconstriction, a major limitation in the use of triptans. Comparisons with triptans in clinical trials for acute treatment of migraine attacks revealed clinical effects similar to those of triptans but better than those of placebo. Telcagepant might provide hope for those who have a poor response to, or are unable to use, older drugs. In patients who need prophylaxis because of frequent attacks of migraine, topiramate is a first-line drug for migraine prevention in many countries; it is generally safe and reasonably well tolerated. Data suggest that topiramate could aid reversion of chronic migraine to episodic migraine.},
  author       = {Edvinsson, Lars and Linde, Mattias},
  issn         = {1474-547X},
  language     = {eng},
  pages        = {645--655},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {New drugs in migraine treatment and prophylaxis: telcagepant and topiramate.},
  url          = {http://dx.doi.org/10.1016/S0140-6736(10)60323-6},
  volume       = {May 4},
  year         = {2010},
}