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Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection.

Eliasson, Mette LU ; Mörgelin, Matthias LU ; Farber, Joshua M; Egesten, Arne LU and Albiger, Barbara LU (2010) In Microbes and Infection 12. p.565-573
Abstract
MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-trafficking and angiogenesis. Certain chemokines, including human MIG/CXCL9, exert strong antibacterial activity in vitro, although the importance of this property in vivo is unknown. In the present study, we investigated the expression and a possible role for MIG/CXCL9 in host defense during mucosal airway infection caused by Streptococcus pneumoniae in vivo. We found that intranasal challenge of C57BL/6 wild-type mice with pneumococci elicited production of high levels of MIG/CXCL9 in the lungs via the MyD88-dependent signaling pathway. Whereas both human and murine MIG/CXCL9 showed efficient killing of S. pneumoniae in vitro, MIG/CXCL9... (More)
MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-trafficking and angiogenesis. Certain chemokines, including human MIG/CXCL9, exert strong antibacterial activity in vitro, although the importance of this property in vivo is unknown. In the present study, we investigated the expression and a possible role for MIG/CXCL9 in host defense during mucosal airway infection caused by Streptococcus pneumoniae in vivo. We found that intranasal challenge of C57BL/6 wild-type mice with pneumococci elicited production of high levels of MIG/CXCL9 in the lungs via the MyD88-dependent signaling pathway. Whereas both human and murine MIG/CXCL9 showed efficient killing of S. pneumoniae in vitro, MIG/CXCL9 knock-out mice were not more susceptible to pneumococcal infection. Our data demonstrate that, in vivo this chemokine probably has a redundant role, acting together with other antibacterial peptides and chemokines, in innate and adaptive host defense mechanisms against pneumococcal infections. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbes and Infection
volume
12
pages
565 - 573
publisher
Elsevier
external identifiers
  • wos:000279561500008
  • pmid:20381636
  • scopus:77953011315
ISSN
1769-714X
DOI
10.1016/j.micinf.2010.03.014
language
English
LU publication?
yes
id
33c05dde-30f7-49c8-8473-dfda83de4972 (old id 1595427)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20381636?dopt=Abstract
date added to LUP
2010-05-04 10:53:47
date last changed
2018-07-01 04:21:51
@article{33c05dde-30f7-49c8-8473-dfda83de4972,
  abstract     = {MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-trafficking and angiogenesis. Certain chemokines, including human MIG/CXCL9, exert strong antibacterial activity in vitro, although the importance of this property in vivo is unknown. In the present study, we investigated the expression and a possible role for MIG/CXCL9 in host defense during mucosal airway infection caused by Streptococcus pneumoniae in vivo. We found that intranasal challenge of C57BL/6 wild-type mice with pneumococci elicited production of high levels of MIG/CXCL9 in the lungs via the MyD88-dependent signaling pathway. Whereas both human and murine MIG/CXCL9 showed efficient killing of S. pneumoniae in vitro, MIG/CXCL9 knock-out mice were not more susceptible to pneumococcal infection. Our data demonstrate that, in vivo this chemokine probably has a redundant role, acting together with other antibacterial peptides and chemokines, in innate and adaptive host defense mechanisms against pneumococcal infections.},
  author       = {Eliasson, Mette and Mörgelin, Matthias and Farber, Joshua M and Egesten, Arne and Albiger, Barbara},
  issn         = {1769-714X},
  language     = {eng},
  pages        = {565--573},
  publisher    = {Elsevier},
  series       = {Microbes and Infection},
  title        = {Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection.},
  url          = {http://dx.doi.org/10.1016/j.micinf.2010.03.014},
  volume       = {12},
  year         = {2010},
}