Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Genomics and the irreducible nature of eukaryote cells

Kurland, Charles LU ; Collins, L J and Penny, D (2006) In Science 312(5776). p.1011-1014
Abstract
Large-scale comparative genomics in harness with proteomics has substantiated fundamental features of eukaryote cellular evolution. The evolutionary trajectory of modern eukaryotes is distinct from that of prokaryotes. Data from many sources give no direct evidence that eukaryotes evolved by genome fusion between archaea and bacteria. Comparative genomics shows that, under certain ecological settings, sequence loss and cellular simplification are common modes of evolution. Subcellular architecture of eukaryote cells is in part a physical-chemical consequence of molecular crowding; subcellular compartmentation with specialized proteomes is required for the efficient functioning of proteins.
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
312
issue
5776
pages
1011 - 1014
publisher
American Association for the Advancement of Science
external identifiers
  • pmid:16709776
  • wos:000237628800033
  • scopus:33646726959
  • pmid:16709776
ISSN
1095-9203
DOI
10.1126/science.1121674
language
English
LU publication?
yes
id
45e03395-6f66-476b-b26e-ef6adf92a197 (old id 159573)
date added to LUP
2016-04-01 15:55:42
date last changed
2020-11-22 03:09:38
@article{45e03395-6f66-476b-b26e-ef6adf92a197,
  abstract     = {Large-scale comparative genomics in harness with proteomics has substantiated fundamental features of eukaryote cellular evolution. The evolutionary trajectory of modern eukaryotes is distinct from that of prokaryotes. Data from many sources give no direct evidence that eukaryotes evolved by genome fusion between archaea and bacteria. Comparative genomics shows that, under certain ecological settings, sequence loss and cellular simplification are common modes of evolution. Subcellular architecture of eukaryote cells is in part a physical-chemical consequence of molecular crowding; subcellular compartmentation with specialized proteomes is required for the efficient functioning of proteins.},
  author       = {Kurland, Charles and Collins, L J and Penny, D},
  issn         = {1095-9203},
  language     = {eng},
  number       = {5776},
  pages        = {1011--1014},
  publisher    = {American Association for the Advancement of Science},
  series       = {Science},
  title        = {Genomics and the irreducible nature of eukaryote cells},
  url          = {http://dx.doi.org/10.1126/science.1121674},
  doi          = {10.1126/science.1121674},
  volume       = {312},
  year         = {2006},
}