Genomics and the irreducible nature of eukaryote cells
(2006) In Science 312(5776). p.1011-1014- Abstract
- Large-scale comparative genomics in harness with proteomics has substantiated fundamental features of eukaryote cellular evolution. The evolutionary trajectory of modern eukaryotes is distinct from that of prokaryotes. Data from many sources give no direct evidence that eukaryotes evolved by genome fusion between archaea and bacteria. Comparative genomics shows that, under certain ecological settings, sequence loss and cellular simplification are common modes of evolution. Subcellular architecture of eukaryote cells is in part a physical-chemical consequence of molecular crowding; subcellular compartmentation with specialized proteomes is required for the efficient functioning of proteins.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/159573
- author
- Kurland, Charles LU ; Collins, L J and Penny, D
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 312
- issue
- 5776
- pages
- 1011 - 1014
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:16709776
- wos:000237628800033
- scopus:33646726959
- pmid:16709776
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1121674
- language
- English
- LU publication?
- yes
- id
- 45e03395-6f66-476b-b26e-ef6adf92a197 (old id 159573)
- date added to LUP
- 2016-04-01 15:55:42
- date last changed
- 2024-03-14 20:24:49
@article{45e03395-6f66-476b-b26e-ef6adf92a197,
abstract = {{Large-scale comparative genomics in harness with proteomics has substantiated fundamental features of eukaryote cellular evolution. The evolutionary trajectory of modern eukaryotes is distinct from that of prokaryotes. Data from many sources give no direct evidence that eukaryotes evolved by genome fusion between archaea and bacteria. Comparative genomics shows that, under certain ecological settings, sequence loss and cellular simplification are common modes of evolution. Subcellular architecture of eukaryote cells is in part a physical-chemical consequence of molecular crowding; subcellular compartmentation with specialized proteomes is required for the efficient functioning of proteins.}},
author = {{Kurland, Charles and Collins, L J and Penny, D}},
issn = {{1095-9203}},
language = {{eng}},
number = {{5776}},
pages = {{1011--1014}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science}},
title = {{Genomics and the irreducible nature of eukaryote cells}},
url = {{http://dx.doi.org/10.1126/science.1121674}},
doi = {{10.1126/science.1121674}},
volume = {{312}},
year = {{2006}},
}