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Plasma homocysteine-a marker of vascular disease in elderly patients with mental illness.

Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU (2010) In Clinical Biochemistry 43. p.1056-1059
Abstract
BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. METHOD: We investigated the influence of cobalamin/folate status and renal function on the association between plasma tHcy levels and vascular disease. RESULTS: There was a similar degree of significant difference in plasma tHcy levels between patients with and without vascular disease in all enrolled patients and in a group of patients where all those with signs of cobalamin/folate deficiency and/or impaired renal function had been excluded. Furthermore, logistic regression analysis showed that the age-adjusted plasma... (More)
BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. METHOD: We investigated the influence of cobalamin/folate status and renal function on the association between plasma tHcy levels and vascular disease. RESULTS: There was a similar degree of significant difference in plasma tHcy levels between patients with and without vascular disease in all enrolled patients and in a group of patients where all those with signs of cobalamin/folate deficiency and/or impaired renal function had been excluded. Furthermore, logistic regression analysis showed that the age-adjusted plasma tHcy was the main predictor of vascular disease in both groups of patients. CONCLUSION: The findings suggest that the presence of vascular disease itself is associated with elevated levels of plasma tHcy. Plasma tHcy might be a marker of vascular disease in elderly patients with mental illness. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Biochemistry
volume
43
pages
1056 - 1059
publisher
Elsevier
external identifiers
  • wos:000281721200005
  • pmid:20362566
  • scopus:77956178234
ISSN
1873-2933
DOI
10.1016/j.clinbiochem.2010.03.013
language
English
LU publication?
yes
id
89510a09-91a5-40a8-b7ee-73d5325d162f (old id 1598657)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20362566?dopt=Abstract
date added to LUP
2010-05-03 08:55:44
date last changed
2018-05-29 12:16:36
@article{89510a09-91a5-40a8-b7ee-73d5325d162f,
  abstract     = {BACKGROUND: Total plasma homocysteine (tHcy) concentration is elevated in elderly patients with mental illness, and patients with vascular disease have higher plasma tHcy concentration than patients without vascular disease. METHOD: We investigated the influence of cobalamin/folate status and renal function on the association between plasma tHcy levels and vascular disease. RESULTS: There was a similar degree of significant difference in plasma tHcy levels between patients with and without vascular disease in all enrolled patients and in a group of patients where all those with signs of cobalamin/folate deficiency and/or impaired renal function had been excluded. Furthermore, logistic regression analysis showed that the age-adjusted plasma tHcy was the main predictor of vascular disease in both groups of patients. CONCLUSION: The findings suggest that the presence of vascular disease itself is associated with elevated levels of plasma tHcy. Plasma tHcy might be a marker of vascular disease in elderly patients with mental illness.},
  author       = {Nilsson, Karin and Gustafson, Lars and Hultberg, Björn},
  issn         = {1873-2933},
  language     = {eng},
  pages        = {1056--1059},
  publisher    = {Elsevier},
  series       = {Clinical Biochemistry},
  title        = {Plasma homocysteine-a marker of vascular disease in elderly patients with mental illness.},
  url          = {http://dx.doi.org/10.1016/j.clinbiochem.2010.03.013},
  volume       = {43},
  year         = {2010},
}