The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT
(2022) In International Journal of Radiation Biology 98(3). p.439-451- Abstract
Purpose: Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field. Conclusion: Although hypoxia-driven metastasis and immunosuppression can negatively impact clinical outcome, understanding these processes can also provide tumor-specific vulnerabilities that may be therapeutically exploited. The different oxygen tensions present in tumors and normal tissues may underpin the beneficial FLASH sparing effect seen in normal tissue and represents a... (More)
Purpose: Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field. Conclusion: Although hypoxia-driven metastasis and immunosuppression can negatively impact clinical outcome, understanding these processes can also provide tumor-specific vulnerabilities that may be therapeutically exploited. The different oxygen tensions present in tumors and normal tissues may underpin the beneficial FLASH sparing effect seen in normal tissue and represents a perfect example of advances in the field that can leverage tumor hypoxia to improve future radiotherapy treatments.
(Less)
- author
- Moon, Eui Jung ; Petersson, Kristoffer LU and Olcina, Monica M.
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cancer, FLASH, immune system, metastasis, tumor microenvironment, ultra-high dose rate, women in research
- in
- International Journal of Radiation Biology
- volume
- 98
- issue
- 3
- pages
- 439 - 451
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85118461110
- pmid:34726575
- ISSN
- 0955-3002
- DOI
- 10.1080/09553002.2021.1988178
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2021 The Author(s). Published with license by Taylor and Francis Group, LLC.
- id
- 15a0e18c-6697-485c-88c3-93301cc964c6
- date added to LUP
- 2021-12-02 12:38:49
- date last changed
- 2024-06-17 00:38:58
@article{15a0e18c-6697-485c-88c3-93301cc964c6,
abstract = {{<p>Purpose: Hypoxia (low oxygen) is a common feature of solid tumors that has been intensely studied for more than six decades. Here we review the importance of hypoxia to radiotherapy with a particular focus on the contribution of hypoxia to immune responses, metastatic potential and FLASH radiotherapy, active areas of research by leading women in the field. Conclusion: Although hypoxia-driven metastasis and immunosuppression can negatively impact clinical outcome, understanding these processes can also provide tumor-specific vulnerabilities that may be therapeutically exploited. The different oxygen tensions present in tumors and normal tissues may underpin the beneficial FLASH sparing effect seen in normal tissue and represents a perfect example of advances in the field that can leverage tumor hypoxia to improve future radiotherapy treatments.</p>}},
author = {{Moon, Eui Jung and Petersson, Kristoffer and Olcina, Monica M.}},
issn = {{0955-3002}},
keywords = {{cancer; FLASH; immune system; metastasis; tumor microenvironment; ultra-high dose rate; women in research}},
language = {{eng}},
number = {{3}},
pages = {{439--451}},
publisher = {{Taylor & Francis}},
series = {{International Journal of Radiation Biology}},
title = {{The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT}},
url = {{http://dx.doi.org/10.1080/09553002.2021.1988178}},
doi = {{10.1080/09553002.2021.1988178}},
volume = {{98}},
year = {{2022}},
}