Charles Bonnet Syndrome Adversely Affects Vision-Related Quality of Life in Patients with Glaucoma
(2023) In Ophthalmology Glaucoma- Abstract
Purpose: To investigate the impact of Charles Bonnet syndrome (CBS) on vision-related quality of life (VRQoL) in patients with glaucoma. Design: Cross-sectional cohort study. Participants: Twenty-four patients with CBS and 42 matched controls without CBS out of 337 patients with open-angle glaucoma (OAG) with visual field (VF) loss. Methods: A matching technique was used to identify control patients with similar disease stage, best-corrected visual acuity (BCVA) and age to patients with CBS. Patients’ VRQoL was determined using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25). Rasch-calibrated NEI VFQ-25 scores of the CBS group and the control group were compared. Uni- and multivariable regression analysis was... (More)
Purpose: To investigate the impact of Charles Bonnet syndrome (CBS) on vision-related quality of life (VRQoL) in patients with glaucoma. Design: Cross-sectional cohort study. Participants: Twenty-four patients with CBS and 42 matched controls without CBS out of 337 patients with open-angle glaucoma (OAG) with visual field (VF) loss. Methods: A matching technique was used to identify control patients with similar disease stage, best-corrected visual acuity (BCVA) and age to patients with CBS. Patients’ VRQoL was determined using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25). Rasch-calibrated NEI VFQ-25 scores of the CBS group and the control group were compared. Uni- and multivariable regression analysis was used to evaluate the impact of different factors on VRQoL. Main Outcome Measures: Vision-related quality of life in patients with glaucoma with CBS and without CBS. Results: Vision-related quality of life scores were significantly lower in the CBS group than in the control group on both the visual functioning scale with 39 points (95% confidence interval (CI): 30–48) vs. 52 points (95% CI: 46–58) (P = 0.013) and on the socioemotional scale with 45 points (95% CI: 37–53) vs. 58 points (95% CI: 51–65) (P = 0.015). Univariable regression analysis showed that integrated visual field mean deviation (IVF-MD) (r2 = 0.334, P < 0.001), BCVA in the better eye (r2 = 0.117, P = 0.003), and the presence of CBS (r2 = 0.078, P = 0.013) were significantly correlated to VRQoL scores on the visual functioning scale. Integrated visual field mean deviation (r2 = 0.281, P < 0.001), age (r2 = 0.048, P = 0.042), and the presence of CBS (r2 = 0.076, P = 0.015) were significantly correlated to VRQoL scores on the socioemotional scale. Multivariable regression analysis showed that IVF-MD and the presence of CBS accounted for nearly 40% of the VRQoL score on the visual functioning scale (R2 = 0.393, P < 0.001) and for 34% of the VRQoL score on the socioemotional scale (R2 = 0.339, P < 0.001). Conclusions: Charles Bonnet syndrome had a significant negative association to VRQoL in patients with glaucoma. Presence of CBS should be considered when evaluating VRQoL in patients with glaucoma. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
(Less)
- author
- Randeblad, Patrik ; Singh, Amardeep LU and Peters, Dorothea LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- Charles Bonnet syndrome, Glaucoma, Vision-related quality of life, Visual hallucinations
- in
- Ophthalmology Glaucoma
- publisher
- Elsevier
- external identifiers
-
- pmid:37429533
- scopus:85168468790
- ISSN
- 2589-4234
- DOI
- 10.1016/j.ogla.2023.07.001
- language
- English
- LU publication?
- yes
- id
- 15cbb657-8571-426e-9031-f4899b7e1d1a
- date added to LUP
- 2023-12-06 15:11:27
- date last changed
- 2024-04-19 09:44:42
@article{15cbb657-8571-426e-9031-f4899b7e1d1a,
abstract = {{<p>Purpose: To investigate the impact of Charles Bonnet syndrome (CBS) on vision-related quality of life (VRQoL) in patients with glaucoma. Design: Cross-sectional cohort study. Participants: Twenty-four patients with CBS and 42 matched controls without CBS out of 337 patients with open-angle glaucoma (OAG) with visual field (VF) loss. Methods: A matching technique was used to identify control patients with similar disease stage, best-corrected visual acuity (BCVA) and age to patients with CBS. Patients’ VRQoL was determined using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25). Rasch-calibrated NEI VFQ-25 scores of the CBS group and the control group were compared. Uni- and multivariable regression analysis was used to evaluate the impact of different factors on VRQoL. Main Outcome Measures: Vision-related quality of life in patients with glaucoma with CBS and without CBS. Results: Vision-related quality of life scores were significantly lower in the CBS group than in the control group on both the visual functioning scale with 39 points (95% confidence interval (CI): 30–48) vs. 52 points (95% CI: 46–58) (P = 0.013) and on the socioemotional scale with 45 points (95% CI: 37–53) vs. 58 points (95% CI: 51–65) (P = 0.015). Univariable regression analysis showed that integrated visual field mean deviation (IVF-MD) (r<sup>2</sup> = 0.334, P < 0.001), BCVA in the better eye (r<sup>2</sup> = 0.117, P = 0.003), and the presence of CBS (r<sup>2</sup> = 0.078, P = 0.013) were significantly correlated to VRQoL scores on the visual functioning scale. Integrated visual field mean deviation (r<sup>2</sup> = 0.281, P < 0.001), age (r<sup>2</sup> = 0.048, P = 0.042), and the presence of CBS (r<sup>2</sup> = 0.076, P = 0.015) were significantly correlated to VRQoL scores on the socioemotional scale. Multivariable regression analysis showed that IVF-MD and the presence of CBS accounted for nearly 40% of the VRQoL score on the visual functioning scale (R<sup>2</sup> = 0.393, P < 0.001) and for 34% of the VRQoL score on the socioemotional scale (R<sup>2</sup> = 0.339, P < 0.001). Conclusions: Charles Bonnet syndrome had a significant negative association to VRQoL in patients with glaucoma. Presence of CBS should be considered when evaluating VRQoL in patients with glaucoma. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.</p>}},
author = {{Randeblad, Patrik and Singh, Amardeep and Peters, Dorothea}},
issn = {{2589-4234}},
keywords = {{Charles Bonnet syndrome; Glaucoma; Vision-related quality of life; Visual hallucinations}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Ophthalmology Glaucoma}},
title = {{Charles Bonnet Syndrome Adversely Affects Vision-Related Quality of Life in Patients with Glaucoma}},
url = {{http://dx.doi.org/10.1016/j.ogla.2023.07.001}},
doi = {{10.1016/j.ogla.2023.07.001}},
year = {{2023}},
}