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The preservative 2-(thiocyanomethylthio)benzothiazole : A potential allergen in leather products

Herman, Anne; Goossens, An; Tennstedt, Dominique; Bergendorff, Ola LU ; Isaksson, Marléne LU ; Mowitz, Martin LU and Baeck, Marie (2019) In Contact Dermatitis
Abstract

Background: Allergic contact dermatitis caused by leather is common, and several responsible allergens, such as tanning agents, glues, mercaptobenzothiazole derivatives, and dyes, but also antimicrobials and antifungals, are involved. Material and methods: Three female patients were referred to the Departments of Dermatology in a Belgian university hospital following skin reactions caused by leather products (shoes, belt, and car seats). They were patch tested with the European baseline series and samples of suspected leather products, and additionally with 2-(thiocyanomethylthio)benzothiazole (TCMTB), an antifungal agent previously reported to be a contact allergen in footwear. Chromatographic analyses of samples of all the leather... (More)

Background: Allergic contact dermatitis caused by leather is common, and several responsible allergens, such as tanning agents, glues, mercaptobenzothiazole derivatives, and dyes, but also antimicrobials and antifungals, are involved. Material and methods: Three female patients were referred to the Departments of Dermatology in a Belgian university hospital following skin reactions caused by leather products (shoes, belt, and car seats). They were patch tested with the European baseline series and samples of suspected leather products, and additionally with 2-(thiocyanomethylthio)benzothiazole (TCMTB), an antifungal agent previously reported to be a contact allergen in footwear. Chromatographic analyses of samples of all the leather materials tested were performed at the Department of Occupational and Environmental Dermatology in Malmö, Sweden. Results: The patients reacting to the leather samples were shown to be sensitized to TCMTB, the presence of which could be confirmed by chemical analyses of samples obtained from the patients. Conclusion: Patch tests with TCMTB should be considered in patients with contact dermatitis caused by leather items.

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organization
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Contribution to journal
publication status
epub
subject
keywords
2-(thiocyanomethylthio)benzothiazole, allergic contact dermatitis, antifungal, antimicrobial, CAS no. 21564-17-0, chemical analysis, cross-reactions, footwear, leather, preservative
in
Contact Dermatitis
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85066487758
ISSN
0105-1873
DOI
10.1111/cod.13295
language
English
LU publication?
yes
id
15e28c8b-76ff-461f-9f81-fe8a7aace1e4
date added to LUP
2019-06-19 13:58:12
date last changed
2019-07-09 04:48:50
@article{15e28c8b-76ff-461f-9f81-fe8a7aace1e4,
  abstract     = {<p>Background: Allergic contact dermatitis caused by leather is common, and several responsible allergens, such as tanning agents, glues, mercaptobenzothiazole derivatives, and dyes, but also antimicrobials and antifungals, are involved. Material and methods: Three female patients were referred to the Departments of Dermatology in a Belgian university hospital following skin reactions caused by leather products (shoes, belt, and car seats). They were patch tested with the European baseline series and samples of suspected leather products, and additionally with 2-(thiocyanomethylthio)benzothiazole (TCMTB), an antifungal agent previously reported to be a contact allergen in footwear. Chromatographic analyses of samples of all the leather materials tested were performed at the Department of Occupational and Environmental Dermatology in Malmö, Sweden. Results: The patients reacting to the leather samples were shown to be sensitized to TCMTB, the presence of which could be confirmed by chemical analyses of samples obtained from the patients. Conclusion: Patch tests with TCMTB should be considered in patients with contact dermatitis caused by leather items.</p>},
  author       = {Herman, Anne and Goossens, An and Tennstedt, Dominique and Bergendorff, Ola and Isaksson, Marléne and Mowitz, Martin and Baeck, Marie},
  issn         = {0105-1873},
  keyword      = {2-(thiocyanomethylthio)benzothiazole,allergic contact dermatitis,antifungal,antimicrobial,CAS no. 21564-17-0,chemical analysis,cross-reactions,footwear,leather,preservative},
  language     = {eng},
  month        = {04},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {The preservative 2-(thiocyanomethylthio)benzothiazole : A potential allergen in leather products},
  url          = {http://dx.doi.org/10.1111/cod.13295},
  year         = {2019},
}