Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex
(2018) In Journal of Alzheimer's disease : JAD 62(1). p.85-92- Abstract
Neurofibrillary tangle (NFT) pathology is linked to neurodegeneration in the medial temporal lobe (MTL). Using a tailored pipeline, we correlated atrophy rate, as measured from retrospective longitudinal MRI, with NFT burden, measured from 18F-AV-1451 PET, within MTL regions of earliest NFT pathology. In amyloid-β positive but not amyloid-β negative individuals, we found significant correlation between 18F-AV-1451 uptake and atrophy rate that was strongest in the transentorhinal cortex, the first region with NFT pathology. This supports the role of NFTs in driving neurodegeneration and the utility of 18F-AV-1451 PET and structural measurement of transentorhinal cortex in tracking early tau-mediated disease progression.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/15e8306f-53b5-4414-8d47-a2604ce3111c
- author
- Xie, Long ; Das, Sandhitsu R ; Wisse, Laura E M LU ; Ittyerah, Ranjit ; Yushkevich, Paul A and Wolk, David A
- author collaboration
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Atrophy, Carbolines, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neurofibrillary Tangles/metabolism, Positron-Emission Tomography, Radiopharmaceuticals, Retrospective Studies, Temporal Lobe/diagnostic imaging, tau Proteins/metabolism
- in
- Journal of Alzheimer's disease : JAD
- volume
- 62
- issue
- 1
- pages
- 85 - 92
- publisher
- IOS Press
- external identifiers
-
- scopus:85047980725
- pmid:29439350
- ISSN
- 1387-2877
- DOI
- 10.3233/JAD-170945
- language
- English
- LU publication?
- no
- id
- 15e8306f-53b5-4414-8d47-a2604ce3111c
- date added to LUP
- 2024-02-28 14:50:57
- date last changed
- 2024-03-30 21:39:49
@article{15e8306f-53b5-4414-8d47-a2604ce3111c, abstract = {{<p>Neurofibrillary tangle (NFT) pathology is linked to neurodegeneration in the medial temporal lobe (MTL). Using a tailored pipeline, we correlated atrophy rate, as measured from retrospective longitudinal MRI, with NFT burden, measured from 18F-AV-1451 PET, within MTL regions of earliest NFT pathology. In amyloid-β positive but not amyloid-β negative individuals, we found significant correlation between 18F-AV-1451 uptake and atrophy rate that was strongest in the transentorhinal cortex, the first region with NFT pathology. This supports the role of NFTs in driving neurodegeneration and the utility of 18F-AV-1451 PET and structural measurement of transentorhinal cortex in tracking early tau-mediated disease progression.</p>}}, author = {{Xie, Long and Das, Sandhitsu R and Wisse, Laura E M and Ittyerah, Ranjit and Yushkevich, Paul A and Wolk, David A}}, issn = {{1387-2877}}, keywords = {{Aged; Atrophy; Carbolines; Disease Progression; Female; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neurofibrillary Tangles/metabolism; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Temporal Lobe/diagnostic imaging; tau Proteins/metabolism}}, language = {{eng}}, number = {{1}}, pages = {{85--92}}, publisher = {{IOS Press}}, series = {{Journal of Alzheimer's disease : JAD}}, title = {{Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex}}, url = {{http://dx.doi.org/10.3233/JAD-170945}}, doi = {{10.3233/JAD-170945}}, volume = {{62}}, year = {{2018}}, }