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Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex

Xie, Long ; Das, Sandhitsu R ; Wisse, Laura E M LU orcid ; Ittyerah, Ranjit ; Yushkevich, Paul A and Wolk, David A (2018) In Journal of Alzheimer's disease : JAD 62(1). p.85-92
Abstract

Neurofibrillary tangle (NFT) pathology is linked to neurodegeneration in the medial temporal lobe (MTL). Using a tailored pipeline, we correlated atrophy rate, as measured from retrospective longitudinal MRI, with NFT burden, measured from 18F-AV-1451 PET, within MTL regions of earliest NFT pathology. In amyloid-β positive but not amyloid-β negative individuals, we found significant correlation between 18F-AV-1451 uptake and atrophy rate that was strongest in the transentorhinal cortex, the first region with NFT pathology. This supports the role of NFTs in driving neurodegeneration and the utility of 18F-AV-1451 PET and structural measurement of transentorhinal cortex in tracking early tau-mediated disease progression.

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author
; ; ; ; and
author collaboration
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Atrophy, Carbolines, Disease Progression, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neurofibrillary Tangles/metabolism, Positron-Emission Tomography, Radiopharmaceuticals, Retrospective Studies, Temporal Lobe/diagnostic imaging, tau Proteins/metabolism
in
Journal of Alzheimer's disease : JAD
volume
62
issue
1
pages
85 - 92
publisher
IOS Press
external identifiers
  • scopus:85047980725
  • pmid:29439350
ISSN
1387-2877
DOI
10.3233/JAD-170945
language
English
LU publication?
no
id
15e8306f-53b5-4414-8d47-a2604ce3111c
date added to LUP
2024-02-28 14:50:57
date last changed
2024-03-30 21:39:49
@article{15e8306f-53b5-4414-8d47-a2604ce3111c,
  abstract     = {{<p>Neurofibrillary tangle (NFT) pathology is linked to neurodegeneration in the medial temporal lobe (MTL). Using a tailored pipeline, we correlated atrophy rate, as measured from retrospective longitudinal MRI, with NFT burden, measured from 18F-AV-1451 PET, within MTL regions of earliest NFT pathology. In amyloid-β positive but not amyloid-β negative individuals, we found significant correlation between 18F-AV-1451 uptake and atrophy rate that was strongest in the transentorhinal cortex, the first region with NFT pathology. This supports the role of NFTs in driving neurodegeneration and the utility of 18F-AV-1451 PET and structural measurement of transentorhinal cortex in tracking early tau-mediated disease progression.</p>}},
  author       = {{Xie, Long and Das, Sandhitsu R and Wisse, Laura E M and Ittyerah, Ranjit and Yushkevich, Paul A and Wolk, David A}},
  issn         = {{1387-2877}},
  keywords     = {{Aged; Atrophy; Carbolines; Disease Progression; Female; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neurofibrillary Tangles/metabolism; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Temporal Lobe/diagnostic imaging; tau Proteins/metabolism}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{85--92}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's disease : JAD}},
  title        = {{Early Tau Burden Correlates with Higher Rate of Atrophy in Transentorhinal Cortex}},
  url          = {{http://dx.doi.org/10.3233/JAD-170945}},
  doi          = {{10.3233/JAD-170945}},
  volume       = {{62}},
  year         = {{2018}},
}